ATR dependent activation of Chk2

ATM and ATR are essential regulators of DNA damage checkpoints in mammalian cells through their respective effectors, Chk2 and Chk1. Cross regulation of the ATM‐Chk2 and ATR‐Chk1 pathways is very limited, although ATM and ATR show overlapping function in a partnership and time‐dependent manner. In t...

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Veröffentlicht in:	Journal of cellular physiology 2006-09, Vol.208 (3), p.613-619
Hauptverfasser:	Wang, Xiao Qi, Redpath, J. Leslie, Fan, Sheung Tat, Stanbridge, Eric J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Caffeine - pharmacology Cell Cycle Proteins - metabolism Cell Cycle Proteins - radiation effects Cell Line Checkpoint Kinase 2 DNA-Binding Proteins - deficiency DNA-Binding Proteins - radiation effects Enzyme Activation Fibroblasts Humans Phosphorylation Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - radiation effects Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - radiation effects
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