Lack of RUNX3 regulation in human gastric cancer

It has been proposed that the transcription factor RUNX3 is the product of a gastric tumour suppressor gene. We examined RUNX3 expression in gastric biopsies from 105 patients with different histological presentations. Surprisingly, immunohistochemical staining detected RUNX3 protein expression only...

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Veröffentlicht in:	The Journal of pathology 2006-10, Vol.210 (2), p.141-146
Hauptverfasser:	Friedrich, MJ, Rad, R, Langer, R, Voland, P, Hoefler, H, Schmid, RM, Prinz, C, Gerhard, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biopsy Cell Transformation, Neoplastic - metabolism Core Binding Factor Alpha 3 Subunit - biosynthesis Core Binding Factor Alpha 3 Subunit - genetics Down-Regulation expression Female Gastric Mucosa - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic H. pylori Helicobacter Infections - complications Helicobacter Infections - metabolism Helicobacter pylori human gastric cancer Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) laser capture microdissection Leukocytes - metabolism Male Medical sciences Microdissection - methods Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Staging Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics RNA, Neoplasm - genetics RUNX3 Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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