Donor selection for unrelated cord blood transplants
The number of unrelated cord blood transplants is increasing, with more than 8000 patients reported worldwide. Criteria of donor choice have been identified. Cell dose measured by number of nucleated cells is the most important factor, thus increases in cell dose can partially overcome the presence...
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| Veröffentlicht in: | Current Opinion in Immunology 2006-10, Vol.18 (5), p.565-570 |
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| creator | Gluckman, Eliane Rocha, Vanderson |
| description | The number of unrelated cord blood transplants is increasing, with more than 8000 patients reported worldwide. Criteria of donor choice have been identified. Cell dose measured by number of nucleated cells is the most important factor, thus increases in cell dose can partially overcome the presence of HLA incompatibilities. Overall, increasing the number of HLA incompatibilities is associated with non-engraftment, but it also decreases the risk of relapse in patients with malignant disease, resulting in an absence of effect of HLA incompatibilities on event-free survival (survival without relapse or complications related to the transplant). However, in patients with non-malignant disorders, increasing the number of HLA incompatibilities decreases the overall survival. These results show that criteria of donor choice based on number of infused cells, number of HLA incompatibilities and diagnosis improve outcomes of unrelated cord blood transplants. Currently, owing to the possibility of using a non HLA identical donor, most patients can find a donor, increasing the need for the development of the inventory of cord blood banks. Methods of improving engraftment are currently under investigation. |
| doi_str_mv | 10.1016/j.coi.2006.07.014 |
| format | Article |
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Currently, owing to the possibility of using a non HLA identical donor, most patients can find a donor, increasing the need for the development of the inventory of cord blood banks. 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Criteria of donor choice have been identified. Cell dose measured by number of nucleated cells is the most important factor, thus increases in cell dose can partially overcome the presence of HLA incompatibilities. Overall, increasing the number of HLA incompatibilities is associated with non-engraftment, but it also decreases the risk of relapse in patients with malignant disease, resulting in an absence of effect of HLA incompatibilities on event-free survival (survival without relapse or complications related to the transplant). However, in patients with non-malignant disorders, increasing the number of HLA incompatibilities decreases the overall survival. These results show that criteria of donor choice based on number of infused cells, number of HLA incompatibilities and diagnosis improve outcomes of unrelated cord blood transplants. Currently, owing to the possibility of using a non HLA identical donor, most patients can find a donor, increasing the need for the development of the inventory of cord blood banks. Methods of improving engraftment are currently under investigation.</description><subject>Cord Blood Stem Cell Transplantation - methods</subject><subject>Cord Blood Stem Cell Transplantation - statistics & numerical data</subject><subject>Donor Selection</subject><subject>Hematologic Diseases - therapy</subject><subject>Histocompatibility</subject><subject>HLA Antigens - genetics</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Neoplasms - therapy</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>0952-7915</issn><issn>1879-0372</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_gBfZk7ddJ1-bBE9SP6HgpfeQr4Ut201NtoL_3kgLnsTLDMM88zI8CF1jaDDg9m7TuNg3BKBtQDSA2QmaYylUDVSQUzQHxUktFOYzdJHzBgA4p3COZriViraUzBF7jGNMVQ5DcFMfx6or035MYTBT8JWLyVd2iNFXUzJj3g1mnPIlOuvMkMPVsS_Q-vlpvXytV-8vb8uHVe0Yk1NtsQBiRUe8D17gUhV4zDgOlFuimHCeGSGt450BbqU1hlMBZYEVN4ou0O0hdpfixz7kSW_77MJQfghxn3UrJVOSi39BrCgQiXkB8QF0KeacQqd3qd-a9KUx6B-leqOLUv2jVIPQRWm5uTmG7-02-N-Lo8MC3B-AUFR89iHp7PowuuD7VKRqXwL_jv8Gt5aGTQ</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Gluckman, Eliane</creator><creator>Rocha, Vanderson</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Donor selection for unrelated cord blood transplants</title><author>Gluckman, Eliane ; Rocha, Vanderson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-b1702b7f2dded71dde90d1451e35b2947cd4a78bc5fa05b8baa5370947195a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cord Blood Stem Cell Transplantation - methods</topic><topic>Cord Blood Stem Cell Transplantation - statistics & numerical data</topic><topic>Donor Selection</topic><topic>Hematologic Diseases - therapy</topic><topic>Histocompatibility</topic><topic>HLA Antigens - genetics</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Neoplasms - therapy</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gluckman, Eliane</creatorcontrib><creatorcontrib>Rocha, Vanderson</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gluckman, Eliane</au><au>Rocha, Vanderson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donor selection for unrelated cord blood transplants</atitle><jtitle>Current Opinion in Immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>18</volume><issue>5</issue><spage>565</spage><epage>570</epage><pages>565-570</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><eissn>1365-2567</eissn><abstract>The number of unrelated cord blood transplants is increasing, with more than 8000 patients reported worldwide. Criteria of donor choice have been identified. Cell dose measured by number of nucleated cells is the most important factor, thus increases in cell dose can partially overcome the presence of HLA incompatibilities. Overall, increasing the number of HLA incompatibilities is associated with non-engraftment, but it also decreases the risk of relapse in patients with malignant disease, resulting in an absence of effect of HLA incompatibilities on event-free survival (survival without relapse or complications related to the transplant). However, in patients with non-malignant disorders, increasing the number of HLA incompatibilities decreases the overall survival. These results show that criteria of donor choice based on number of infused cells, number of HLA incompatibilities and diagnosis improve outcomes of unrelated cord blood transplants. 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| ispartof | Current Opinion in Immunology, 2006-10, Vol.18 (5), p.565-570 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; ScienceDirect Journals (5 years ago - present); IngentaConnect Free/Open Access Journals; PubMed Central |
| subjects | Cord Blood Stem Cell Transplantation - methods Cord Blood Stem Cell Transplantation - statistics & numerical data Donor Selection Hematologic Diseases - therapy Histocompatibility HLA Antigens - genetics HLA Antigens - immunology Humans Neoplasms - therapy Transplantation, Homologous Treatment Outcome |
| title | Donor selection for unrelated cord blood transplants |
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