Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy
Protein signatures in disease, a portion of the protein complement of cells that directly reflects disease related changes, provide a unique data set that may be correlated with or be an aid to more effective diagnosis, prognosis, and response to therapy. A recent article in this Journal from the au...
Gespeichert in:
| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2005-12, Vol.65 (23), p.10642-10645 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10645 |
|---|---|
| container_issue | 23 |
| container_start_page | 10642 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 65 |
| creator | CAPRIOLI, Richard M |
| description | Protein signatures in disease, a portion of the protein complement of cells that directly reflects disease related changes, provide a unique data set that may be correlated with or be an aid to more effective diagnosis, prognosis, and response to therapy. A recent article in this Journal from the author's laboratory described the protein analysis of glioma tissue and the discovery of protein signatures for assessing the stage of disease as well as their correlation with patient survival. This investigation used direct proteomic analysis of glioma biopsies, the discovery of molecular signatures for stage and outcome, and identification of specific proteins of this signature group. This minireview discusses the background and present state of the technology used in this work and the role that direct tissue analysis can play in the discovery of high-quality protein signatures. |
| doi_str_mv | 10.1158/0008-5472.CAN-04-3581 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68849210</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68849210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-22f56f6d9d02df0e6ea76d6483dd51bf16080a8d60eb54baba5b3f69042bc4923</originalsourceid><addsrcrecordid>eNqFkUlPwzAQhS0EgrL8BFAucCJlvMY9VmWVEFzgbDleilGaFDs59N_jiEKPnGyPv3kzeg-hcwxTjLm8AQBZclaR6WL-UgIrKZd4D00wp7KsGOP7aPLHHKHjlD7zk2Pgh-gIC0oIATZB_taZsP5wMbTLYh273oW2WHWNM0OjY5HCstX9EF0qct3o1rhY9CGlIVf6rtDBjh826GXbpZCuR43fq25t0Wdpvd6cogOvm-TOtucJer-_e1s8ls-vD0-L-XNpGNC-JMRz4YWdWSDWgxNOV8IKJqm1HNceC5CgpRXgas5qXWteUy9mwEht2IzQE3T1o5vX-Mo79moVknFNo1vXDUkJKTOG4V8QV4yArGgG-Q9oYpdSdF6tY1jpuFEY1JiEGl1Wo8sqJ6GAqTGJ3HexHTDUK2d3XVvrM3C5BXQyuvExmxvSjqsopgwk_QZOOZJS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17420873</pqid></control><display><type>article</type><title>Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><creator>CAPRIOLI, Richard M</creator><creatorcontrib>CAPRIOLI, Richard M</creatorcontrib><description>Protein signatures in disease, a portion of the protein complement of cells that directly reflects disease related changes, provide a unique data set that may be correlated with or be an aid to more effective diagnosis, prognosis, and response to therapy. A recent article in this Journal from the author's laboratory described the protein analysis of glioma tissue and the discovery of protein signatures for assessing the stage of disease as well as their correlation with patient survival. This investigation used direct proteomic analysis of glioma biopsies, the discovery of molecular signatures for stage and outcome, and identification of specific proteins of this signature group. This minireview discusses the background and present state of the technology used in this work and the role that direct tissue analysis can play in the discovery of high-quality protein signatures.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-04-3581</identifier><identifier>PMID: 16322204</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; General aspects (metabolism, cell proliferation, established cell line...) ; Humans ; Medical sciences ; Neoplasm Proteins - analysis ; Neoplasms - diagnosis ; Neoplasms - metabolism ; Neoplasms - therapy ; Prognosis ; Proteomics - methods ; Tumor cell ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2005-12, Vol.65 (23), p.10642-10645</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-22f56f6d9d02df0e6ea76d6483dd51bf16080a8d60eb54baba5b3f69042bc4923</citedby><cites>FETCH-LOGICAL-c403t-22f56f6d9d02df0e6ea76d6483dd51bf16080a8d60eb54baba5b3f69042bc4923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3345,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17313408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16322204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAPRIOLI, Richard M</creatorcontrib><title>Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Protein signatures in disease, a portion of the protein complement of cells that directly reflects disease related changes, provide a unique data set that may be correlated with or be an aid to more effective diagnosis, prognosis, and response to therapy. A recent article in this Journal from the author's laboratory described the protein analysis of glioma tissue and the discovery of protein signatures for assessing the stage of disease as well as their correlation with patient survival. This investigation used direct proteomic analysis of glioma biopsies, the discovery of molecular signatures for stage and outcome, and identification of specific proteins of this signature group. This minireview discusses the background and present state of the technology used in this work and the role that direct tissue analysis can play in the discovery of high-quality protein signatures.</description><subject>Biological and medical sciences</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>Prognosis</subject><subject>Proteomics - methods</subject><subject>Tumor cell</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlPwzAQhS0EgrL8BFAucCJlvMY9VmWVEFzgbDleilGaFDs59N_jiEKPnGyPv3kzeg-hcwxTjLm8AQBZclaR6WL-UgIrKZd4D00wp7KsGOP7aPLHHKHjlD7zk2Pgh-gIC0oIATZB_taZsP5wMbTLYh273oW2WHWNM0OjY5HCstX9EF0qct3o1rhY9CGlIVf6rtDBjh826GXbpZCuR43fq25t0Wdpvd6cogOvm-TOtucJer-_e1s8ls-vD0-L-XNpGNC-JMRz4YWdWSDWgxNOV8IKJqm1HNceC5CgpRXgas5qXWteUy9mwEht2IzQE3T1o5vX-Mo79moVknFNo1vXDUkJKTOG4V8QV4yArGgG-Q9oYpdSdF6tY1jpuFEY1JiEGl1Wo8sqJ6GAqTGJ3HexHTDUK2d3XVvrM3C5BXQyuvExmxvSjqsopgwk_QZOOZJS</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>CAPRIOLI, Richard M</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy</title><author>CAPRIOLI, Richard M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-22f56f6d9d02df0e6ea76d6483dd51bf16080a8d60eb54baba5b3f69042bc4923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>General aspects (metabolism, cell proliferation, established cell line...)</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>Prognosis</topic><topic>Proteomics - methods</topic><topic>Tumor cell</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAPRIOLI, Richard M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAPRIOLI, Richard M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>65</volume><issue>23</issue><spage>10642</spage><epage>10645</epage><pages>10642-10645</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Protein signatures in disease, a portion of the protein complement of cells that directly reflects disease related changes, provide a unique data set that may be correlated with or be an aid to more effective diagnosis, prognosis, and response to therapy. A recent article in this Journal from the author's laboratory described the protein analysis of glioma tissue and the discovery of protein signatures for assessing the stage of disease as well as their correlation with patient survival. This investigation used direct proteomic analysis of glioma biopsies, the discovery of molecular signatures for stage and outcome, and identification of specific proteins of this signature group. This minireview discusses the background and present state of the technology used in this work and the role that direct tissue analysis can play in the discovery of high-quality protein signatures.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16322204</pmid><doi>10.1158/0008-5472.CAN-04-3581</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2005-12, Vol.65 (23), p.10642-10645 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68849210 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Biological and medical sciences General aspects (metabolism, cell proliferation, established cell line...) Humans Medical sciences Neoplasm Proteins - analysis Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - therapy Prognosis Proteomics - methods Tumor cell Tumors |
| title | Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T20%3A24%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deciphering%20protein%20molecular%20signatures%20in%20cancer%20tissues%20to%20aid%20in%20diagnosis,%20prognosis,%20and%20therapy&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=CAPRIOLI,%20Richard%20M&rft.date=2005-12-01&rft.volume=65&rft.issue=23&rft.spage=10642&rft.epage=10645&rft.pages=10642-10645&rft.issn=0008-5472&rft.eissn=1538-7445&rft.coden=CNREA8&rft_id=info:doi/10.1158/0008-5472.CAN-04-3581&rft_dat=%3Cproquest_cross%3E68849210%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17420873&rft_id=info:pmid/16322204&rfr_iscdi=true |