High Thioredoxin Expression Is Associated with Resistance to Docetaxel in Primary Breast Cancer

Purpose: Thioredoxin overexpression is suggested to be associated with resistance to several chemotherapeutic agents in vitro . In the present study, it has been studied whether or not high thioredoxin expression is associated with resistance to docetaxel therapy in breast cancer patients. Patients...

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Veröffentlicht in:	Clinical cancer research 2005-12, Vol.11 (23), p.8425-8430
Hauptverfasser:	SEUNG JIN KIM, MIYOSHI, Yasuo, TAGUCHI, Tetsuya, TAMAKI, Yasuhiro, NAKAMURA, Hajime, YODOI, Junji, KATO, Kikuya, NOGUCHI, Shinzaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences BRCA1 Protein - metabolism Breast Cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Chemotherapy, Adjuvant Docetaxel Drug Resistance, Neoplasm Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Neoadjuvant Therapy Neoplasm Invasiveness - pathology Neoplasm Staging Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Estrogen - metabolism Resistance Taxoids - therapeutic use Thioredoxin Thioredoxins - metabolism Tumor Suppressor Protein p53 - metabolism Tumors
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