Epilepsy in patients with spina bifida in the lumbosacral region
This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschi...
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| Veröffentlicht in: | Neurosurgical review 2006-10, Vol.29 (4), p.327-332 |
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| creator | Yoshida, Fumiaki Morioka, Takato Hashiguchi, Kimiaki Kawamura, Tadao Miyagi, Yasushi Nagata, Shinji Mihara, Futoshi Ohshio, Mayu Sasaki, Tomio |
| description | This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschisis (MS, 45), and lumbosacral lipoma (LL, 20). Nine cases had epileptic disorders, and all showed MS. Meticulous neuroradiological investigations revealed cerebral abnormalities such as polymicrogyria or hypogenesis of the corpus callosum in all epileptic cases. Locations of cerebral abnormalities topographically correlated with areas of interictal EEG abnormalities. Although all epileptic cases had ventriculoperitoneal (VP) shunt for hydrocephalus before the onset of epilepsy, interictal EEG abnormalities could not be explained by location of the VP shunt. In all LL patients, neither history of epilepsy nor cerebral abnormalities were noted on magnetic resonance imaging (MRI). Epileptogenesis in spina bifida patients seemed to correlate with coexisting cerebral abnormalities in MS patients rather than with the VP shunt. However, not all spina bifida patients associated with cerebral abnormalities had epilepsy, and not all cerebral abnormalities were epileptogenic, suggesting that epilepsy in spina bifida patients was multifactorial. |
| doi_str_mv | 10.1007/s10143-006-0035-7 |
| format | Article |
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We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschisis (MS, 45), and lumbosacral lipoma (LL, 20). Nine cases had epileptic disorders, and all showed MS. Meticulous neuroradiological investigations revealed cerebral abnormalities such as polymicrogyria or hypogenesis of the corpus callosum in all epileptic cases. Locations of cerebral abnormalities topographically correlated with areas of interictal EEG abnormalities. Although all epileptic cases had ventriculoperitoneal (VP) shunt for hydrocephalus before the onset of epilepsy, interictal EEG abnormalities could not be explained by location of the VP shunt. In all LL patients, neither history of epilepsy nor cerebral abnormalities were noted on magnetic resonance imaging (MRI). Epileptogenesis in spina bifida patients seemed to correlate with coexisting cerebral abnormalities in MS patients rather than with the VP shunt. However, not all spina bifida patients associated with cerebral abnormalities had epilepsy, and not all cerebral abnormalities were epileptogenic, suggesting that epilepsy in spina bifida patients was multifactorial.</description><identifier>ISSN: 0344-5607</identifier><identifier>EISSN: 1437-2320</identifier><identifier>DOI: 10.1007/s10143-006-0035-7</identifier><identifier>PMID: 16933125</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Adult ; Age of Onset ; Anticonvulsants - therapeutic use ; Child ; Child, Preschool ; Electroencephalography ; Epilepsy - etiology ; Epilepsy - pathology ; Epilepsy - physiopathology ; Female ; Humans ; Infant ; Lipoma - classification ; Lipoma - pathology ; Lumbosacral Region - pathology ; Magnetic Resonance Imaging ; Male ; Meningeal Neoplasms - classification ; Meningeal Neoplasms - pathology ; Meningocele - classification ; Meningocele - pathology ; Spinal Dysraphism - classification ; Spinal Dysraphism - complications ; Spinal Dysraphism - physiopathology ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Neurosurgical review, 2006-10, Vol.29 (4), p.327-332</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-823a112609437b4a9fe5773cde99cf5960d56afec87826b3b5c01d66474525933</citedby><cites>FETCH-LOGICAL-c299t-823a112609437b4a9fe5773cde99cf5960d56afec87826b3b5c01d66474525933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16933125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshida, Fumiaki</creatorcontrib><creatorcontrib>Morioka, Takato</creatorcontrib><creatorcontrib>Hashiguchi, Kimiaki</creatorcontrib><creatorcontrib>Kawamura, Tadao</creatorcontrib><creatorcontrib>Miyagi, Yasushi</creatorcontrib><creatorcontrib>Nagata, Shinji</creatorcontrib><creatorcontrib>Mihara, Futoshi</creatorcontrib><creatorcontrib>Ohshio, Mayu</creatorcontrib><creatorcontrib>Sasaki, Tomio</creatorcontrib><title>Epilepsy in patients with spina bifida in the lumbosacral region</title><title>Neurosurgical review</title><addtitle>Neurosurg Rev</addtitle><description>This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschisis (MS, 45), and lumbosacral lipoma (LL, 20). Nine cases had epileptic disorders, and all showed MS. Meticulous neuroradiological investigations revealed cerebral abnormalities such as polymicrogyria or hypogenesis of the corpus callosum in all epileptic cases. Locations of cerebral abnormalities topographically correlated with areas of interictal EEG abnormalities. Although all epileptic cases had ventriculoperitoneal (VP) shunt for hydrocephalus before the onset of epilepsy, interictal EEG abnormalities could not be explained by location of the VP shunt. In all LL patients, neither history of epilepsy nor cerebral abnormalities were noted on magnetic resonance imaging (MRI). Epileptogenesis in spina bifida patients seemed to correlate with coexisting cerebral abnormalities in MS patients rather than with the VP shunt. However, not all spina bifida patients associated with cerebral abnormalities had epilepsy, and not all cerebral abnormalities were epileptogenic, suggesting that epilepsy in spina bifida patients was multifactorial.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Electroencephalography</subject><subject>Epilepsy - etiology</subject><subject>Epilepsy - pathology</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Lipoma - classification</subject><subject>Lipoma - pathology</subject><subject>Lumbosacral Region - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Meningeal Neoplasms - classification</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningocele - classification</subject><subject>Meningocele - pathology</subject><subject>Spinal Dysraphism - classification</subject><subject>Spinal Dysraphism - complications</subject><subject>Spinal Dysraphism - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0344-5607</issn><issn>1437-2320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotlZ_gBvJyl30Jpm8dkqpDyi40XXIZDI2Mi8nM4j_3pQWXFwu3HvO4fAhdE3hjgKo-0SBFpwAyDxcEHWClvmgCOMMTtESeFEQIUEt0EVKXwBUGaDnaEGl4ZwysUQPmyE2YUi_OHZ4cFMM3ZTwT5x2OA2xc7iMdazc_jvtAm7mtuyT86Nr8Bg-Y99dorPaNSlcHfcKfTxt3tcvZPv2_Lp-3BLPjJmIZtxRyiSY3K8snKmDUIr7Khjja2EkVEK6OnitNJMlL4UHWklZqEIwkduu0O0hdxj77zmkybYx-dA0rgv9nKzUutBGiyykB6Ef-5TGUNthjK0bfy0Fu8dmD9hsxmb32KzKnptj-Fy2ofp3HDnxP9asZuY</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Yoshida, Fumiaki</creator><creator>Morioka, Takato</creator><creator>Hashiguchi, Kimiaki</creator><creator>Kawamura, Tadao</creator><creator>Miyagi, Yasushi</creator><creator>Nagata, Shinji</creator><creator>Mihara, Futoshi</creator><creator>Ohshio, Mayu</creator><creator>Sasaki, Tomio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200610</creationdate><title>Epilepsy in patients with spina bifida in the lumbosacral region</title><author>Yoshida, Fumiaki ; Morioka, Takato ; Hashiguchi, Kimiaki ; Kawamura, Tadao ; Miyagi, Yasushi ; Nagata, Shinji ; Mihara, Futoshi ; Ohshio, Mayu ; Sasaki, Tomio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-823a112609437b4a9fe5773cde99cf5960d56afec87826b3b5c01d66474525933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Electroencephalography</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy - pathology</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Lipoma - classification</topic><topic>Lipoma - pathology</topic><topic>Lumbosacral Region - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Meningeal Neoplasms - classification</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Meningocele - classification</topic><topic>Meningocele - pathology</topic><topic>Spinal Dysraphism - classification</topic><topic>Spinal Dysraphism - complications</topic><topic>Spinal Dysraphism - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Fumiaki</creatorcontrib><creatorcontrib>Morioka, Takato</creatorcontrib><creatorcontrib>Hashiguchi, Kimiaki</creatorcontrib><creatorcontrib>Kawamura, Tadao</creatorcontrib><creatorcontrib>Miyagi, Yasushi</creatorcontrib><creatorcontrib>Nagata, Shinji</creatorcontrib><creatorcontrib>Mihara, Futoshi</creatorcontrib><creatorcontrib>Ohshio, Mayu</creatorcontrib><creatorcontrib>Sasaki, Tomio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgical review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Fumiaki</au><au>Morioka, Takato</au><au>Hashiguchi, Kimiaki</au><au>Kawamura, Tadao</au><au>Miyagi, Yasushi</au><au>Nagata, Shinji</au><au>Mihara, Futoshi</au><au>Ohshio, Mayu</au><au>Sasaki, Tomio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epilepsy in patients with spina bifida in the lumbosacral region</atitle><jtitle>Neurosurgical review</jtitle><addtitle>Neurosurg Rev</addtitle><date>2006-10</date><risdate>2006</risdate><volume>29</volume><issue>4</issue><spage>327</spage><epage>332</epage><pages>327-332</pages><issn>0344-5607</issn><eissn>1437-2320</eissn><abstract>This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschisis (MS, 45), and lumbosacral lipoma (LL, 20). Nine cases had epileptic disorders, and all showed MS. Meticulous neuroradiological investigations revealed cerebral abnormalities such as polymicrogyria or hypogenesis of the corpus callosum in all epileptic cases. Locations of cerebral abnormalities topographically correlated with areas of interictal EEG abnormalities. Although all epileptic cases had ventriculoperitoneal (VP) shunt for hydrocephalus before the onset of epilepsy, interictal EEG abnormalities could not be explained by location of the VP shunt. In all LL patients, neither history of epilepsy nor cerebral abnormalities were noted on magnetic resonance imaging (MRI). Epileptogenesis in spina bifida patients seemed to correlate with coexisting cerebral abnormalities in MS patients rather than with the VP shunt. However, not all spina bifida patients associated with cerebral abnormalities had epilepsy, and not all cerebral abnormalities were epileptogenic, suggesting that epilepsy in spina bifida patients was multifactorial.</abstract><cop>Germany</cop><pmid>16933125</pmid><doi>10.1007/s10143-006-0035-7</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Age of Onset Anticonvulsants - therapeutic use Child Child, Preschool Electroencephalography Epilepsy - etiology Epilepsy - pathology Epilepsy - physiopathology Female Humans Infant Lipoma - classification Lipoma - pathology Lumbosacral Region - pathology Magnetic Resonance Imaging Male Meningeal Neoplasms - classification Meningeal Neoplasms - pathology Meningocele - classification Meningocele - pathology Spinal Dysraphism - classification Spinal Dysraphism - complications Spinal Dysraphism - physiopathology Tomography, X-Ray Computed Treatment Outcome |
| title | Epilepsy in patients with spina bifida in the lumbosacral region |
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