$Posaconazole for treatment of refractory invasive fungal disease$

Posaconazole for treatment of refractory invasive fungal disease

Summary Invasive fungal infections are usually associated with immunocompromised states About 40–60% of these patients are refractory to standard antifungal therapy We describe the effect of posoconazole in the treatment of a 12 years‐old girl with uncontrolled diabetes mellitus with life‐threatenin...

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Veröffentlicht in:	Mycoses 2006-11, Vol.49 (s1), p.37-41
Hauptverfasser:	Notheis, G., Tarani, L., Costantino, F., Jansson, A., Rosenecker, J., Friederici, D., Belohradsky, B. H., Reinhardt, D., Seger, R., Schweinitz, D. V., Wintergerst, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use aspergillosis Aspergillosis - drug therapy Aspergillosis - microbiology Aspergillus nidulans Aspergillus nidulans - drug effects Aspergillus nidulans - isolation & purification Central Nervous System Fungal Infections - drug therapy Central Nervous System Fungal Infections - microbiology Child Child, Preschool children chronic granulomatous disease diabetes mellitus Diabetes Mellitus, Type 1 - complications Drug Resistance, Fungal Female Granulomatous Disease, Chronic - complications Humans Immunocompromised Host immunodeficiency Lung Diseases, Fungal - drug therapy Lung Diseases, Fungal - microbiology Male Mucor mucor mycosis Mucormycosis - drug therapy Mucormycosis - microbiology Posaconazole Rhizopus - drug effects Rhizopus - isolation & purification Sinusitis - drug therapy Sinusitis - microbiology Treatment Outcome Triazoles - administration & dosage Triazoles - therapeutic use zygomycosis
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Beschreibung
Zusammenfassung:	Summary Invasive fungal infections are usually associated with immunocompromised states About 40–60% of these patients are refractory to standard antifungal therapy We describe the effect of posoconazole in the treatment of a 12 years‐old girl with uncontrolled diabetes mellitus with life‐threatening cerebral mucor mycosis and a 4 year old girl boy with chronic granulomatous disease presenting with invasive Aspergillus nidulans infection.
ISSN:	0933-7407 1439-0507
DOI:	10.1111/j.1439-0507.2006.01301.x