Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis

IGF-binding protein-3 (IGFBP-3) has been reported to exert a protective influence on the pathogenesis of colorectal cancer. This may reflect its modulation of IGF-I bioactivity as well as IGF-I-independent effects on cell proliferation and apoptosis. Although local expression of IGF-I in the colon i...

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Veröffentlicht in:	Endocrine-related cancer 2005-12, Vol.12 (4), p.891-901
Hauptverfasser:	Jenkins, P J, Khalaf, S, Ogunkolade, W, McCarthy, K, David, T, Hands, R E, Davies, D, Bustin, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Line, Tumor Cell Proliferation - drug effects Colon - chemistry Colon - metabolism Colonic Neoplasms - chemistry Colonic Neoplasms - metabolism Humans Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor Binding Protein 3 - pharmacology Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Original Phosphatidylinositol 3-Kinases - antagonists & inhibitors Protein Kinase Inhibitors - pharmacology Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Stromal Cells - drug effects Stromal Cells - metabolism
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