Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C

Aims/hypothesis Familial partial lipodystrophy (FPLD) and obesity are both associated with increased risks of type 2 diabetes and cardiovascular disease. Although adipokines have been implicated, few data exist in subjects with FPLD; therefore we investigated a family with FPLD due to a lamin A/C mu...

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Veröffentlicht in:	Diabetologia 2005-12, Vol.48 (12), p.2641-2649
Hauptverfasser:	Wong, S. P. Y, Huda, M, English, P, Bargiotta, A, Wilding, J. P. H, Johnson, A, Corrall, R, Pinkney, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	adipokines adiponectin Adiponectin - blood Adult Biological and medical sciences Case-Control Studies Dermatology diabetes Diabetes Mellitus, Lipoatrophic - blood Diabetes Mellitus, Lipoatrophic - genetics Diabetes Mellitus, Lipoatrophic - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Homeostasis Humans insulin resistance Insulin Resistance - physiology Interleukin-1 - blood Interleukin-6 - blood Laminin - genetics Laminin - physiology Leptin - blood Lipodystrophy Male Medical sciences Metabolic diseases Metabolic Syndrome - blood Metabolic Syndrome - physiopathology Middle Aged Multivariate Analysis Mutation Obesity Obesity - blood Obesity - physiopathology Resistin - blood Skin involvement in other diseases. Miscellaneous. General aspects TNF-α Tumor Necrosis Factor-alpha - analysis
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