Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice
Both Cinnamomi cassiae and Rhodiola rosea extracts are used as anti‐diabetic folk medicines. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of Cinnamo...
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| Veröffentlicht in: | BioFactors (Oxford) 2006, Vol.26 (3), p.209-219 |
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| description | Both Cinnamomi cassiae and Rhodiola rosea extracts are used as anti‐diabetic folk medicines. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of Cinnamomi cassiae and Rhodiola rosea extracts on blood glucose, lipid peroxidation, the level of reduced glutathione and its related enzymes (glutathione reductase, glutathione S‐transferase), and the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice.
Diabetic C57BL/Ks db/db mice were used as experimental models. Mice were divided into control (n =10), Cinnamomi cassiae (200 mg/kg/day, n = 10), and Rhodiola rosea (200 mg/kg/day, n =10) treated groups for 12 weeks of treatment. These type II diabetic mice were used to investigate the effects of Cinnamomi cassiae and Rhodiola rosea on blood glucose, reduced glutathione, glutathione reductase, glutathione S‐transferase, glutathione peroxidase, lipid peroxidation, catalase and superoxide dismutase.
Cinnamomi cassiae and Rhodiola rosea extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S‐transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver. Extract treatment also significantly decreased lipid peroxidation.
Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications. |
| doi_str_mv | 10.1002/biof.5520260306 |
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Diabetic C57BL/Ks db/db mice were used as experimental models. Mice were divided into control (n =10), Cinnamomi cassiae (200 mg/kg/day, n = 10), and Rhodiola rosea (200 mg/kg/day, n =10) treated groups for 12 weeks of treatment. These type II diabetic mice were used to investigate the effects of Cinnamomi cassiae and Rhodiola rosea on blood glucose, reduced glutathione, glutathione reductase, glutathione S‐transferase, glutathione peroxidase, lipid peroxidation, catalase and superoxide dismutase.
Cinnamomi cassiae and Rhodiola rosea extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S‐transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver. Extract treatment also significantly decreased lipid peroxidation.
Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications.</description><identifier>ISSN: 0951-6433</identifier><identifier>EISSN: 1872-8081</identifier><identifier>DOI: 10.1002/biof.5520260306</identifier><identifier>PMID: 16971752</identifier><language>eng</language><publisher>Amsterdam: IOS Press</publisher><subject>Animals ; antioxidant enzymes ; Antioxidants - pharmacology ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; blood glucose level ; Body Weight - drug effects ; Catalase - drug effects ; Catalase - metabolism ; Cinnamomi cassiae ; Cinnamomum aromaticum - chemistry ; diabetes ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Disease Models, Animal ; Glutathione - drug effects ; Glutathione - metabolism ; Glutathione Peroxidase - drug effects ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - drug effects ; Glutathione Reductase - metabolism ; Glutathione Transferase - drug effects ; Glutathione Transferase - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Organ Size - drug effects ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Rhodiola - chemistry ; Rhodiola rosea ; Superoxide Dismutase - drug effects ; Superoxide Dismutase - metabolism</subject><ispartof>BioFactors (Oxford), 2006, Vol.26 (3), p.209-219</ispartof><rights>Copyright © 2006 International Union of Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3856-94e125cc0abb16855d4c97f726ee795884a41ce90f9537577a2a2c05c58e8e463</citedby><cites>FETCH-LOGICAL-c3856-94e125cc0abb16855d4c97f726ee795884a41ce90f9537577a2a2c05c58e8e463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbiof.5520260306$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbiof.5520260306$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16971752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sung Hee</creatorcontrib><creatorcontrib>Hyun, Sun Hee</creatorcontrib><creatorcontrib>Choung, Se Young</creatorcontrib><title>Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice</title><title>BioFactors (Oxford)</title><addtitle>BioFactors</addtitle><description>Both Cinnamomi cassiae and Rhodiola rosea extracts are used as anti‐diabetic folk medicines. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of Cinnamomi cassiae and Rhodiola rosea extracts on blood glucose, lipid peroxidation, the level of reduced glutathione and its related enzymes (glutathione reductase, glutathione S‐transferase), and the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice.
Diabetic C57BL/Ks db/db mice were used as experimental models. Mice were divided into control (n =10), Cinnamomi cassiae (200 mg/kg/day, n = 10), and Rhodiola rosea (200 mg/kg/day, n =10) treated groups for 12 weeks of treatment. These type II diabetic mice were used to investigate the effects of Cinnamomi cassiae and Rhodiola rosea on blood glucose, reduced glutathione, glutathione reductase, glutathione S‐transferase, glutathione peroxidase, lipid peroxidation, catalase and superoxide dismutase.
Cinnamomi cassiae and Rhodiola rosea extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S‐transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver. Extract treatment also significantly decreased lipid peroxidation.
Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications.</description><subject>Animals</subject><subject>antioxidant enzymes</subject><subject>Antioxidants - pharmacology</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>blood glucose level</subject><subject>Body Weight - drug effects</subject><subject>Catalase - drug effects</subject><subject>Catalase - metabolism</subject><subject>Cinnamomi cassiae</subject><subject>Cinnamomum aromaticum - chemistry</subject><subject>diabetes</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Disease Models, Animal</subject><subject>Glutathione - drug effects</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - drug effects</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - drug effects</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione Transferase - drug effects</subject><subject>Glutathione Transferase - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Organ Size - drug effects</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Rhodiola - chemistry</subject><subject>Rhodiola rosea</subject><subject>Superoxide Dismutase - drug effects</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0951-6433</issn><issn>1872-8081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQRy0EokvLmRvyiVvasR1_RJzKii2VVrRQEEczcSbCkMRtnIXtf09Wu6Li1NNc3nvS_Bh7JeBUAMizOqb2VGsJ0oAC84QthLOycODEU7aASovClEodsRc5_wQQCkr3nB0JU1lhtVyw7-fDFNM2NjjF38SpbSlMmaeWL-MwYJ_6yAPmHJE4Dg3__CM1MXXIx5QJOW2nEXdCHHg3B8ad2USsaYqB9zHQCXvWYpfp5eEes6-r91-WH4r11cXl8nxdBOW0KaqShNQhANa1ME7rpgyVba00RLbSzpVYikAVtJVWVluLEmUAHbQjR6VRx-zNvns7prsN5cn3MQfqOhwobbI3c8IKkDN4tgfD_EIeqfW3Y-xxvPcC_G5UvxvVP4w6G68P6U3dU_PAH1acgbd74E_s6P6xnn93ebX6L1_s7Zgn2v6zcfzljZ1_9d8-Xvj1NSh5s_rkV-ov7LqTPQ</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Kim, Sung Hee</creator><creator>Hyun, Sun Hee</creator><creator>Choung, Se Young</creator><general>IOS Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice</title><author>Kim, Sung Hee ; Hyun, Sun Hee ; Choung, Se Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3856-94e125cc0abb16855d4c97f726ee795884a41ce90f9537577a2a2c05c58e8e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>antioxidant enzymes</topic><topic>Antioxidants - pharmacology</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>blood glucose level</topic><topic>Body Weight - drug effects</topic><topic>Catalase - drug effects</topic><topic>Catalase - metabolism</topic><topic>Cinnamomi cassiae</topic><topic>Cinnamomum aromaticum - chemistry</topic><topic>diabetes</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Disease Models, Animal</topic><topic>Glutathione - drug effects</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - drug effects</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - drug effects</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione Transferase - drug effects</topic><topic>Glutathione Transferase - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Organ Size - drug effects</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Rhodiola - chemistry</topic><topic>Rhodiola rosea</topic><topic>Superoxide Dismutase - drug effects</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sung Hee</creatorcontrib><creatorcontrib>Hyun, Sun Hee</creatorcontrib><creatorcontrib>Choung, Se Young</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BioFactors (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sung Hee</au><au>Hyun, Sun Hee</au><au>Choung, Se Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice</atitle><jtitle>BioFactors (Oxford)</jtitle><addtitle>BioFactors</addtitle><date>2006</date><risdate>2006</risdate><volume>26</volume><issue>3</issue><spage>209</spage><epage>219</epage><pages>209-219</pages><issn>0951-6433</issn><eissn>1872-8081</eissn><abstract>Both Cinnamomi cassiae and Rhodiola rosea extracts are used as anti‐diabetic folk medicines. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of Cinnamomi cassiae and Rhodiola rosea extracts on blood glucose, lipid peroxidation, the level of reduced glutathione and its related enzymes (glutathione reductase, glutathione S‐transferase), and the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice.
Diabetic C57BL/Ks db/db mice were used as experimental models. Mice were divided into control (n =10), Cinnamomi cassiae (200 mg/kg/day, n = 10), and Rhodiola rosea (200 mg/kg/day, n =10) treated groups for 12 weeks of treatment. These type II diabetic mice were used to investigate the effects of Cinnamomi cassiae and Rhodiola rosea on blood glucose, reduced glutathione, glutathione reductase, glutathione S‐transferase, glutathione peroxidase, lipid peroxidation, catalase and superoxide dismutase.
Cinnamomi cassiae and Rhodiola rosea extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S‐transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver. Extract treatment also significantly decreased lipid peroxidation.
Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications.</abstract><cop>Amsterdam</cop><pub>IOS Press</pub><pmid>16971752</pmid><doi>10.1002/biof.5520260306</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals antioxidant enzymes Antioxidants - pharmacology Blood Glucose - drug effects Blood Glucose - metabolism blood glucose level Body Weight - drug effects Catalase - drug effects Catalase - metabolism Cinnamomi cassiae Cinnamomum aromaticum - chemistry diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Disease Models, Animal Glutathione - drug effects Glutathione - metabolism Glutathione Peroxidase - drug effects Glutathione Peroxidase - metabolism Glutathione Reductase - drug effects Glutathione Reductase - metabolism Glutathione Transferase - drug effects Glutathione Transferase - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Organ Size - drug effects Phytotherapy - methods Plant Extracts - pharmacology Rhodiola - chemistry Rhodiola rosea Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism |
| title | Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice |
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