1-Aminomethylbenzocycloalkanes: Conformationally Restricted Hallucinogenic Phenethylamine Analogues as Functionally Selective 5-HT2A Receptor Agonists

A series of conformationally restricted analogues of the hallucinogenic phenethylamine 1 (2,5-dimethoxy-4-bromophenethylamine, 2C-B) was synthesized to test several hypotheses concerning the bioactive conformation of phenethylamine ligands upon binding to the 5-HT2A receptor. These benzocycloalkane...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2006-09, Vol.49 (19), p.5794-5803
Hauptverfasser:	McLean, Thomas H, Parrish, Jason C, Braden, Michael R, Marona-Lewicka, Danuta, Gallardo-Godoy, Alejandra, Nichols, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - biosynthesis Binding, Competitive Biological and medical sciences Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - pharmacology Cells, Cultured Crystallography, X-Ray Discrimination Learning - drug effects Hallucinogens - chemical synthesis Hallucinogens - chemistry Hallucinogens - pharmacology Humans Inositol Phosphates - biosynthesis Ligands Lysergic Acid Diethylamide - pharmacology Male Medical sciences Methylamines - chemical synthesis Methylamines - chemistry Methylamines - pharmacology Models, Molecular Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Phenethylamines - chemical synthesis Phenethylamines - chemistry Phenethylamines - pharmacology Radioligand Assay Rats Rats, Sprague-Dawley Serotonin 5-HT2 Receptor Agonists Serotoninergic system Stereoisomerism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!