Catalyst-Controlled Asymmetric Synthesis of Fostriecin and 8-epi-Fostriecin

Catalytic asymmetric synthesis of the natural antibiotic fostriecin (CI-920) and its analogue 8-epi-fostriecin and evaluation of their biological activity are described. We used four catalytic asymmetric reactions to construct all of the chiral centers of fostriecin and 8-epi-fostriecin; cyanosilyla...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-12, Vol.127 (48), p.17111-17117
Hauptverfasser:	Maki, Keisuke, Motoki, Rie, Fujii, Kunihiko, Kanai, Motomu, Kobayashi, Takayasu, Tamura, Shinri, Shibasaki, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemical synthesis Alkenes - chemistry Alkenes - pharmacology Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antineoplastic agents Biological and medical sciences Catalysis Chemistry Chemotherapy Crystallography, X-Ray Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Medical sciences Molecular Structure Organic chemistry Pharmacology. Drug treatments Phosphoprotein Phosphatases - antagonists & inhibitors Polyenes Preparations and properties Pyrones Streptomyces - chemistry
Online-Zugang:	Volltext
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