Design and Synthesis of Dual Peroxisome Proliferator-Activated Receptors γ and δ Agonists as Novel Euglycemic Agents with a Reduced Weight Gain Profile

The design and synthesis of the dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonist (R)-3-{4-[3-(4-chloro-2-phenoxy-phenoxy)-butoxy]-2-ethyl-phenyl}-propionic acid (20) for the treatment of type 2 diabetes and associated dyslipidemia is described. The compound possesses a potent dual...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-09, Vol.49 (19), p.5649-5652
Hauptverfasser:	Xu, Yanping, Etgen, Garret J, Broderick, Carol L, Canada, Emily, Gonzalez, Isabel, Lamar, Jason, Montrose-Rafizadeh, Chahrzad, Oldham, Brian A, Osborne, John J, Xie, Chaoyu, Shi, Qing, Winneroski, Leonard L, York, Jeremy, Yumibe, Nathan, Zink, Richard, Mantlo, Nathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - metabolism Cell Line Diabetes Mellitus, Type 2 - drug therapy Drug Design Dyslipidemias - drug therapy Female General and cellular metabolism. Vitamins Humans Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Male Medical sciences Mice Pharmacology. Drug treatments Phenyl Ethers - chemical synthesis Phenyl Ethers - chemistry Phenyl Ethers - pharmacology Phenylpropionates - chemical synthesis Phenylpropionates - chemistry Phenylpropionates - pharmacology PPAR alpha - genetics PPAR delta - agonists PPAR gamma - agonists Radioligand Assay Stereoisomerism Transcriptional Activation Weight Gain - drug effects
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