Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts
Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts. We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and mig...
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| Veröffentlicht in: | Kidney international 2005-12, Vol.68 (6), p.2890-2900 |
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| creator | Misra, Sanjay Doherty, Michael G. Woodrum, David Homburger, Jay Mandrekar, Jaywant N. Elkouri, Stephane Sabater, Enrique A. Bjarnason, Haraldur Fu, Alex A. Glockner, James F. Greene, Eddie L. Mukhopadhyay, Debabrata |
| description | Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts.
We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and migration of these cells is greatest within the first two weeks following graft placement, resulting in increased matrix metalloproteinase-2 (MMP-2) activity.
Polytetrafluoroethylene grafts from the iliac artery to the ipsilateral iliac vein were placed in 23 pigs and 5-Bromo-2′-deoxyuridine (BrdU) was given at 24 and 48 hours after surgery to assess cell proliferation and migration. Angiography and magnetic resonance angiography was performed. Animals were euthanized on day three (N = 6), day seven, (N = 5), day 14 (N = 6), and days 19 to 26 (N = 6) after graft placement, and stenotic tissue and unaffected contralateral iliac vein were removed for zymography and immunostaining.
Migration of cells derived from the adventitia and media peaked at day 14. Adventitial diameter of the stenotic vein decreased, while the intima to media ratio increased. MMP-2 activity peaks at day seven in the adventitia and days 19 to 26 in the intima.
These results confirm our hypothesis that the source of cells resulting in venous stenosis formation is derived from the adventitia and media, with cell migration being greatest within the first two weeks after graft placement with translocation of these cells into the intima at four weeks. MMP-2 activity peaks at day seven in the adventitia and again at days 19 to 26 in the intima. A key to limiting venous stenosis formation may lie in inhibiting MMP-2 by adventitial and medial targeting. |
| doi_str_mv | 10.1111/j.1523-1755.2005.00763.x |
| format | Article |
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We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and migration of these cells is greatest within the first two weeks following graft placement, resulting in increased matrix metalloproteinase-2 (MMP-2) activity.
Polytetrafluoroethylene grafts from the iliac artery to the ipsilateral iliac vein were placed in 23 pigs and 5-Bromo-2′-deoxyuridine (BrdU) was given at 24 and 48 hours after surgery to assess cell proliferation and migration. Angiography and magnetic resonance angiography was performed. Animals were euthanized on day three (N = 6), day seven, (N = 5), day 14 (N = 6), and days 19 to 26 (N = 6) after graft placement, and stenotic tissue and unaffected contralateral iliac vein were removed for zymography and immunostaining.
Migration of cells derived from the adventitia and media peaked at day 14. Adventitial diameter of the stenotic vein decreased, while the intima to media ratio increased. MMP-2 activity peaks at day seven in the adventitia and days 19 to 26 in the intima.
These results confirm our hypothesis that the source of cells resulting in venous stenosis formation is derived from the adventitia and media, with cell migration being greatest within the first two weeks after graft placement with translocation of these cells into the intima at four weeks. MMP-2 activity peaks at day seven in the adventitia and again at days 19 to 26 in the intima. A key to limiting venous stenosis formation may lie in inhibiting MMP-2 by adventitial and medial targeting.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2005.00763.x</identifier><identifier>PMID: 16316367</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Arteriovenous Shunt, Surgical - adverse effects ; Biological and medical sciences ; cell migration ; Cell Movement ; dialysis access ; Graft Occlusion, Vascular - etiology ; Graft Occlusion, Vascular - pathology ; Hyperplasia ; Iliac Artery - enzymology ; Iliac Artery - pathology ; Iliac Vein - enzymology ; Iliac Vein - pathology ; intimal hyperplasia ; Magnetic Resonance Angiography ; Matrix Metalloproteinase 2 - metabolism ; Medical sciences ; Nephrology. Urinary tract diseases ; Polytetrafluoroethylene ; stenosis ; Swine ; Thrombosis - etiology ; Thrombosis - pathology ; Tunica Intima - pathology ; Tunica Media - pathology</subject><ispartof>Kidney international, 2005-12, Vol.68 (6), p.2890-2900</ispartof><rights>2005 International Society of Nephrology</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-f565efe88627d7a2a3b48d7e54839002526ea0f6fc840cd35f9d6606247b47803</citedby><cites>FETCH-LOGICAL-c501t-f565efe88627d7a2a3b48d7e54839002526ea0f6fc840cd35f9d6606247b47803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210116494?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17390896$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16316367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misra, Sanjay</creatorcontrib><creatorcontrib>Doherty, Michael G.</creatorcontrib><creatorcontrib>Woodrum, David</creatorcontrib><creatorcontrib>Homburger, Jay</creatorcontrib><creatorcontrib>Mandrekar, Jaywant N.</creatorcontrib><creatorcontrib>Elkouri, Stephane</creatorcontrib><creatorcontrib>Sabater, Enrique A.</creatorcontrib><creatorcontrib>Bjarnason, Haraldur</creatorcontrib><creatorcontrib>Fu, Alex A.</creatorcontrib><creatorcontrib>Glockner, James F.</creatorcontrib><creatorcontrib>Greene, Eddie L.</creatorcontrib><creatorcontrib>Mukhopadhyay, Debabrata</creatorcontrib><title>Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts.
We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and migration of these cells is greatest within the first two weeks following graft placement, resulting in increased matrix metalloproteinase-2 (MMP-2) activity.
Polytetrafluoroethylene grafts from the iliac artery to the ipsilateral iliac vein were placed in 23 pigs and 5-Bromo-2′-deoxyuridine (BrdU) was given at 24 and 48 hours after surgery to assess cell proliferation and migration. Angiography and magnetic resonance angiography was performed. Animals were euthanized on day three (N = 6), day seven, (N = 5), day 14 (N = 6), and days 19 to 26 (N = 6) after graft placement, and stenotic tissue and unaffected contralateral iliac vein were removed for zymography and immunostaining.
Migration of cells derived from the adventitia and media peaked at day 14. Adventitial diameter of the stenotic vein decreased, while the intima to media ratio increased. MMP-2 activity peaks at day seven in the adventitia and days 19 to 26 in the intima.
These results confirm our hypothesis that the source of cells resulting in venous stenosis formation is derived from the adventitia and media, with cell migration being greatest within the first two weeks after graft placement with translocation of these cells into the intima at four weeks. MMP-2 activity peaks at day seven in the adventitia and again at days 19 to 26 in the intima. A key to limiting venous stenosis formation may lie in inhibiting MMP-2 by adventitial and medial targeting.</description><subject>Animals</subject><subject>Arteriovenous Shunt, Surgical - adverse effects</subject><subject>Biological and medical sciences</subject><subject>cell migration</subject><subject>Cell Movement</subject><subject>dialysis access</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Graft Occlusion, Vascular - pathology</subject><subject>Hyperplasia</subject><subject>Iliac Artery - enzymology</subject><subject>Iliac Artery - pathology</subject><subject>Iliac Vein - enzymology</subject><subject>Iliac Vein - pathology</subject><subject>intimal hyperplasia</subject><subject>Magnetic Resonance Angiography</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polytetrafluoroethylene</subject><subject>stenosis</subject><subject>Swine</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - pathology</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc2OFCEUhStG47Sjj6AhJrqrEiigqOU48S-ZxI2uCQ23ZuhQ0ALVdq99cenpzkziRkJCuPe7JwdO0yCCO1LXh01HOO1bMnDeUYx5h_Eg-m7_pFk9NJ42K4wlbynv5UXzIucNrvexx8-bCyL6usWwav5c2R2E4orTHiWYowXvwi367codcsEk0BksmnVJbo9mKNr7uE2xgAu101KkTXE7Vw6VRhptYzIuANKpQHKxascl16o_FChJT36JKUK5O3io1G2tlPyyeTZpn-HV-bxsfn7-9OP6a3vz_cu366ub1nBMSjtxwWECKQUd7KCp7tdM2gE4k_2IMeVUgMaTmIxk2NieT6MVAgvKhjUbJO4vm_cn3er_1wK5qNllA97rANWlElIyQUdWwbf_gJu4pFC9KUowIYLdQ_IEmRRzTjCpbXKzTgdFsDqmpDbqGIY6hqGOKan7lNS-jr456y_rGezj4DmWCrw7Azob7aekg3H5kRvqg-UoKvf6xAVdlgQPAGMjr0K1__HUh_qtOwdJZeMgGLAugSnKRvd_t38BtL69LA</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Misra, Sanjay</creator><creator>Doherty, Michael G.</creator><creator>Woodrum, David</creator><creator>Homburger, Jay</creator><creator>Mandrekar, Jaywant N.</creator><creator>Elkouri, Stephane</creator><creator>Sabater, Enrique A.</creator><creator>Bjarnason, Haraldur</creator><creator>Fu, Alex A.</creator><creator>Glockner, James F.</creator><creator>Greene, Eddie L.</creator><creator>Mukhopadhyay, Debabrata</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts</title><author>Misra, Sanjay ; Doherty, Michael G. ; Woodrum, David ; Homburger, Jay ; Mandrekar, Jaywant N. ; Elkouri, Stephane ; Sabater, Enrique A. ; Bjarnason, Haraldur ; Fu, Alex A. ; Glockner, James F. ; Greene, Eddie L. ; Mukhopadhyay, Debabrata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-f565efe88627d7a2a3b48d7e54839002526ea0f6fc840cd35f9d6606247b47803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Arteriovenous Shunt, Surgical - adverse effects</topic><topic>Biological and medical sciences</topic><topic>cell migration</topic><topic>Cell Movement</topic><topic>dialysis access</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Graft Occlusion, Vascular - pathology</topic><topic>Hyperplasia</topic><topic>Iliac Artery - enzymology</topic><topic>Iliac Artery - pathology</topic><topic>Iliac Vein - enzymology</topic><topic>Iliac Vein - pathology</topic><topic>intimal hyperplasia</topic><topic>Magnetic Resonance Angiography</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Polytetrafluoroethylene</topic><topic>stenosis</topic><topic>Swine</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - pathology</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misra, Sanjay</creatorcontrib><creatorcontrib>Doherty, Michael G.</creatorcontrib><creatorcontrib>Woodrum, David</creatorcontrib><creatorcontrib>Homburger, Jay</creatorcontrib><creatorcontrib>Mandrekar, Jaywant N.</creatorcontrib><creatorcontrib>Elkouri, Stephane</creatorcontrib><creatorcontrib>Sabater, Enrique A.</creatorcontrib><creatorcontrib>Bjarnason, Haraldur</creatorcontrib><creatorcontrib>Fu, Alex A.</creatorcontrib><creatorcontrib>Glockner, James F.</creatorcontrib><creatorcontrib>Greene, Eddie L.</creatorcontrib><creatorcontrib>Mukhopadhyay, Debabrata</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misra, Sanjay</au><au>Doherty, Michael G.</au><au>Woodrum, David</au><au>Homburger, Jay</au><au>Mandrekar, Jaywant N.</au><au>Elkouri, Stephane</au><au>Sabater, Enrique A.</au><au>Bjarnason, Haraldur</au><au>Fu, Alex A.</au><au>Glockner, James F.</au><au>Greene, Eddie L.</au><au>Mukhopadhyay, Debabrata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>68</volume><issue>6</issue><spage>2890</spage><epage>2900</epage><pages>2890-2900</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts.
We hypothesized the source of early proliferating cells contributing to venous stenosis formation in a porcine hemodialysis grafts is the adventitia and media, and migration of these cells is greatest within the first two weeks following graft placement, resulting in increased matrix metalloproteinase-2 (MMP-2) activity.
Polytetrafluoroethylene grafts from the iliac artery to the ipsilateral iliac vein were placed in 23 pigs and 5-Bromo-2′-deoxyuridine (BrdU) was given at 24 and 48 hours after surgery to assess cell proliferation and migration. Angiography and magnetic resonance angiography was performed. Animals were euthanized on day three (N = 6), day seven, (N = 5), day 14 (N = 6), and days 19 to 26 (N = 6) after graft placement, and stenotic tissue and unaffected contralateral iliac vein were removed for zymography and immunostaining.
Migration of cells derived from the adventitia and media peaked at day 14. Adventitial diameter of the stenotic vein decreased, while the intima to media ratio increased. MMP-2 activity peaks at day seven in the adventitia and days 19 to 26 in the intima.
These results confirm our hypothesis that the source of cells resulting in venous stenosis formation is derived from the adventitia and media, with cell migration being greatest within the first two weeks after graft placement with translocation of these cells into the intima at four weeks. MMP-2 activity peaks at day seven in the adventitia and again at days 19 to 26 in the intima. A key to limiting venous stenosis formation may lie in inhibiting MMP-2 by adventitial and medial targeting.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16316367</pmid><doi>10.1111/j.1523-1755.2005.00763.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Animals Arteriovenous Shunt, Surgical - adverse effects Biological and medical sciences cell migration Cell Movement dialysis access Graft Occlusion, Vascular - etiology Graft Occlusion, Vascular - pathology Hyperplasia Iliac Artery - enzymology Iliac Artery - pathology Iliac Vein - enzymology Iliac Vein - pathology intimal hyperplasia Magnetic Resonance Angiography Matrix Metalloproteinase 2 - metabolism Medical sciences Nephrology. Urinary tract diseases Polytetrafluoroethylene stenosis Swine Thrombosis - etiology Thrombosis - pathology Tunica Intima - pathology Tunica Media - pathology |
| title | Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts |
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