β-Catenin Regulates Myogenesis by Relieving I-mfa-Mediated Suppression of Myogenic Regulatory Factors in P19 Cells

Wnt/β-catenin signaling plays a critical role in embryonic myogenesis. Here we show that, in P19 embryonic carcinoma stem cells, Wnt/β-catenin signaling initiates the myogenic process depends on β-catenin-mediated relief of I-mfa (inhibitor of MyoD Family a) suppression of myogenic regulatory factor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (48), p.17378-17383
Hauptverfasser:	Weijun Pan, Yingying Jia, Jiyong Wang, Donglei Tao, Xiaoqing Gan, Tsiokas, Leonidas, Jing, Naihe, Wu, Dianqing, Li, Lin, Roeland Nusse
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies beta Catenin - metabolism Biological Sciences Biology Cancer Cell Differentiation - physiology Cell Fractionation Cell Line, Tumor Cell lines Cellular differentiation Embryos Immunoprecipitation Mice Microscopy, Fluorescence Muscle development Muscle Development - physiology Myogenic Regulatory Factors - metabolism Plasmids RNA, Small Interfering - genetics Rodents Signal Transduction - physiology Skeletal muscle Small interfering RNA Stem cells Stem Cells - metabolism Stem Cells - physiology T lymphocytes Transcriptional regulatory elements Two-Hybrid System Techniques
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