Prediction of retention times of proteins in hydrophobic interaction chromatography using only their amino acid composition

This paper focuses on the prediction of the dimensionless retention time of proteins (DRT) in hydrophobic interaction chromatography (HIC) by means of mathematical models based, essentially, only on aminoacidic composition. The results show that such prediction is indeed possible. Our main contribut...

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Veröffentlicht in:	Journal of Chromatography A 2005-12, Vol.1098 (1), p.44-54
Hauptverfasser:	Salgado, J. Cristian, Rapaport, Ivan, Asenjo, Juan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid composition Amino Acids - chemistry Analytical chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Affinity - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology General aspects, investigation methods Hydrophobic and Hydrophilic Interactions Hydrophobic interaction chromatography Hydrophobicity Mathematical modelling Models, Theoretical Other chromatographic methods Proteins Proteins - chemistry Proteins - isolation & purification Retention time prediction Solvents - chemistry
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