Insulin signaling in the central nervous system: learning to survive

Insulin is best known for its role in peripheral glucose homeostasis. Less studied, but not less important, is its role in the central nervous system. Insulin and its receptor are located in the central nervous system and are both implicated in neuronal survival and synaptic plasticity. Interestingl...

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Veröffentlicht in:	Progress in neurobiology 2006-07, Vol.79 (4), p.205-221
Hauptverfasser:	van der Heide, Lars P, Ramakers, Geert M J, Smidt, Marten P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - physiology Central Nervous System - metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism Humans Insulin - metabolism Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neuronal Plasticity - physiology Neurons - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - physiology
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