A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy
Distal sensory polyneuropathy (DSP) is the most frequent neurological complication of HIV infection. Neuropathic symptoms vary from mild paresthesias to severe pain that respond only partially to symptomatic treatment. Forty-five subjects with human immunodeficiency virus (HIV)-associated symptomati...
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| Veröffentlicht in: | Journal of neurovirology 2006-08, Vol.12 (4), p.328-331 |
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| creator | Schifitto, Giovanni Yiannoutsos, Constantin T Simpson, David M Marra, Christina M Singer, Elyse J Kolson, Dennis L Nath, Avindra Berger, Joseph R. Navia, Bradford Group (ACTG) 301 Team, Adult AIDS Clinical Trials |
| description | Distal sensory polyneuropathy (DSP) is the most frequent neurological complication of HIV infection. Neuropathic symptoms vary from mild paresthesias to severe pain that respond only partially to symptomatic treatment. Forty-five subjects with human immunodeficiency virus (HIV)-associated symptomatic DSP (SDSP) were enrolled in a randomized, multicenter, 16-week placebo-controlled study of memantine, an N-methyl-D-aspartate (NMDA) uncompetitive antagonist. Although memantine was well tolerated, no trend toward clinical benefit was observed. Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP. |
| doi_str_mv | 10.1080/13550280600873835 |
| format | Article |
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Neuropathic symptoms vary from mild paresthesias to severe pain that respond only partially to symptomatic treatment. Forty-five subjects with human immunodeficiency virus (HIV)-associated symptomatic DSP (SDSP) were enrolled in a randomized, multicenter, 16-week placebo-controlled study of memantine, an N-methyl-D-aspartate (NMDA) uncompetitive antagonist. Although memantine was well tolerated, no trend toward clinical benefit was observed. Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1080/13550280600873835</identifier><identifier>PMID: 16966223</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Excitatory Amino Acid Antagonists - therapeutic use ; Female ; HIV - growth & development ; HIV Infections - complications ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Memantine - therapeutic use ; Nervous system (semeiology, syndromes) ; Neurology ; Peripheral Nervous System Diseases - drug therapy ; Peripheral Nervous System Diseases - virology ; Placebos ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral diseases of the nervous system</subject><ispartof>Journal of neurovirology, 2006-08, Vol.12 (4), p.328-331</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-507f489f02e5e036c7647c100c4d843e2ee3c08b80d15926dd1fc7b17e6fd59e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13550280600873835$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13550280600873835$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18149904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16966223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schifitto, Giovanni</creatorcontrib><creatorcontrib>Yiannoutsos, Constantin T</creatorcontrib><creatorcontrib>Simpson, David M</creatorcontrib><creatorcontrib>Marra, Christina M</creatorcontrib><creatorcontrib>Singer, Elyse J</creatorcontrib><creatorcontrib>Kolson, Dennis L</creatorcontrib><creatorcontrib>Nath, Avindra</creatorcontrib><creatorcontrib>Berger, Joseph R.</creatorcontrib><creatorcontrib>Navia, Bradford</creatorcontrib><creatorcontrib>Group (ACTG) 301 Team, Adult AIDS Clinical Trials</creatorcontrib><creatorcontrib>Adult AIDS Clinical Trials Group (ACTG) 301 tEAM</creatorcontrib><title>A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy</title><title>Journal of neurovirology</title><addtitle>J Neurovirol</addtitle><description>Distal sensory polyneuropathy (DSP) is the most frequent neurological complication of HIV infection. Neuropathic symptoms vary from mild paresthesias to severe pain that respond only partially to symptomatic treatment. Forty-five subjects with human immunodeficiency virus (HIV)-associated symptomatic DSP (SDSP) were enrolled in a randomized, multicenter, 16-week placebo-controlled study of memantine, an N-methyl-D-aspartate (NMDA) uncompetitive antagonist. Although memantine was well tolerated, no trend toward clinical benefit was observed. Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Female</subject><subject>HIV - growth & development</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memantine - therapeutic use</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Peripheral Nervous System Diseases - drug therapy</subject><subject>Peripheral Nervous System Diseases - virology</subject><subject>Placebos</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral diseases of the nervous system</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFTEUxYNY7If-AW4kG92NzfdkcFWKrULBja6HvMwNkzKTPPOhzH_fPN6DLgq6uhfO7xwu9yD0npLPlGhyTbmUhGmiCNE911y-QhdUct0xIfjrtje9a4A4R5c5PxJCuWL6DTqnalCKMX6B_t7g_WIs7GJnYygpLgtMOJc6bTg6vMJqQvEBsIsJlxlwSWDKCqEc5Lk2Gft1rSFO4Lz1EOyG__hUc2dyjtabcsiDkGPacICa4t6UeXuLzpxZMrw7zSv06-7rz9tv3cOP---3Nw-dFbwvnSS9E3pwhIEEwpXtlegtJcSKSQsODIBboneaTFQOTE0Tdbbf0R6Um-QA_Ap9OubuU_xdIZdx9dnCspgAseZRaS2YVuy_IB24pFSqBtIjaFPMOYEb98mvJm0jJeOhlvFFLc3z4RRedytMz45TDw34eAJMtmZxyQTr8zOnqRgGIhr35cj50ApZzQxmKbM1CcbHWFNor_zHGU9BZKlT</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Schifitto, Giovanni</creator><creator>Yiannoutsos, Constantin T</creator><creator>Simpson, David M</creator><creator>Marra, Christina M</creator><creator>Singer, Elyse J</creator><creator>Kolson, Dennis L</creator><creator>Nath, Avindra</creator><creator>Berger, Joseph R.</creator><creator>Navia, Bradford</creator><creator>Group (ACTG) 301 Team, Adult AIDS Clinical Trials</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy</title><author>Schifitto, Giovanni ; Yiannoutsos, Constantin T ; Simpson, David M ; Marra, Christina M ; Singer, Elyse J ; Kolson, Dennis L ; Nath, Avindra ; Berger, Joseph R. ; Navia, Bradford ; Group (ACTG) 301 Team, Adult AIDS Clinical Trials</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-507f489f02e5e036c7647c100c4d843e2ee3c08b80d15926dd1fc7b17e6fd59e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Female</topic><topic>HIV - growth & development</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memantine - therapeutic use</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Peripheral Nervous System Diseases - drug therapy</topic><topic>Peripheral Nervous System Diseases - virology</topic><topic>Placebos</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schifitto, Giovanni</creatorcontrib><creatorcontrib>Yiannoutsos, Constantin T</creatorcontrib><creatorcontrib>Simpson, David M</creatorcontrib><creatorcontrib>Marra, Christina M</creatorcontrib><creatorcontrib>Singer, Elyse J</creatorcontrib><creatorcontrib>Kolson, Dennis L</creatorcontrib><creatorcontrib>Nath, Avindra</creatorcontrib><creatorcontrib>Berger, Joseph R.</creatorcontrib><creatorcontrib>Navia, Bradford</creatorcontrib><creatorcontrib>Group (ACTG) 301 Team, Adult AIDS Clinical Trials</creatorcontrib><creatorcontrib>Adult AIDS Clinical Trials Group (ACTG) 301 tEAM</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schifitto, Giovanni</au><au>Yiannoutsos, Constantin T</au><au>Simpson, David M</au><au>Marra, Christina M</au><au>Singer, Elyse J</au><au>Kolson, Dennis L</au><au>Nath, Avindra</au><au>Berger, Joseph R.</au><au>Navia, Bradford</au><au>Group (ACTG) 301 Team, Adult AIDS Clinical Trials</au><aucorp>Adult AIDS Clinical Trials Group (ACTG) 301 tEAM</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy</atitle><jtitle>Journal of neurovirology</jtitle><addtitle>J Neurovirol</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>12</volume><issue>4</issue><spage>328</spage><epage>331</epage><pages>328-331</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>Distal sensory polyneuropathy (DSP) is the most frequent neurological complication of HIV infection. 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| subjects | Adult Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Excitatory Amino Acid Antagonists - therapeutic use Female HIV - growth & development HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Memantine - therapeutic use Nervous system (semeiology, syndromes) Neurology Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - virology Placebos Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases of the nervous system |
| title | A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathy |
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