Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists
The synthesis of the novel fibrinogen receptor antagonists 9a– 9h is reported. The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-10, Vol.16 (20), p.5294-5297 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 16 |
| creator | Malovichko, Olga L. Petrus, Anna S. Krysko, Andrei A. Kabanova, Tatyana A. Andronati, Sergei A. Karaseva, Tamara L. Kiriyak, Anna V. |
| description | The synthesis of the novel fibrinogen receptor antagonists
9a–
9h is reported.
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to α
IIbβ
3 on washed human platelets. |
| doi_str_mv | 10.1016/j.bmcl.2006.07.090 |
| format | Article |
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9a–
9h is reported.
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to α
IIbβ
3 on washed human platelets.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2006.07.090</identifier><identifier>PMID: 16919941</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>1,2,3,4-Tetrahydroisoquinoline ; Binding, Competitive - drug effects ; Biological and medical sciences ; Biological Assay ; Blood. Blood coagulation. Reticuloendothelial system ; Drug Evaluation, Preclinical ; Fibrinogen receptor antagonists ; Humans ; Medical sciences ; Molecular Mimicry ; Molecular Structure ; Pharmacology. Drug treatments ; Phthalic Acids - chemical synthesis ; Phthalic Acids - chemistry ; Phthalic Acids - pharmacology ; Platelet aggregation ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - chemical synthesis ; Platelet Aggregation Inhibitors - chemistry ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Glycoprotein GPIIb-IIIa Complex - drug effects ; Protein Binding - drug effects ; Receptors, Fibrinogen - antagonists & inhibitors ; RGD mimetics ; Stereoisomerism ; Structure-Activity Relationship ; α IIbβ 3</subject><ispartof>Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5294-5297</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-575246d4257c5a1febcfabf7620b504287da69bcd9ec0e9e837d859c9dcc519d3</citedby><cites>FETCH-LOGICAL-c415t-575246d4257c5a1febcfabf7620b504287da69bcd9ec0e9e837d859c9dcc519d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2006.07.090$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18146063$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16919941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malovichko, Olga L.</creatorcontrib><creatorcontrib>Petrus, Anna S.</creatorcontrib><creatorcontrib>Krysko, Andrei A.</creatorcontrib><creatorcontrib>Kabanova, Tatyana A.</creatorcontrib><creatorcontrib>Andronati, Sergei A.</creatorcontrib><creatorcontrib>Karaseva, Tamara L.</creatorcontrib><creatorcontrib>Kiriyak, Anna V.</creatorcontrib><title>Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>The synthesis of the novel fibrinogen receptor antagonists
9a–
9h is reported.
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to α
IIbβ
3 on washed human platelets.</description><subject>1,2,3,4-Tetrahydroisoquinoline</subject><subject>Binding, Competitive - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Drug Evaluation, Preclinical</subject><subject>Fibrinogen receptor antagonists</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Mimicry</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Phthalic Acids - chemical synthesis</subject><subject>Phthalic Acids - chemistry</subject><subject>Phthalic Acids - pharmacology</subject><subject>Platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - chemical synthesis</subject><subject>Platelet Aggregation Inhibitors - chemistry</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - drug effects</subject><subject>Protein Binding - drug effects</subject><subject>Receptors, Fibrinogen - antagonists & inhibitors</subject><subject>RGD mimetics</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>α IIbβ 3</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqH_AgfdHTdG8lnaQ74EX2Q4UFLwreQjqp3snQ3RmTzMD--80wA3vTU0HV8xZFPYR8oNBQoPJ62wyznRoGIBvoGlDwiqwol7xuOYjXZAVKQt0r_ueCXKa0BaAcOH9LLqhUVClOVyTfYvQHk_0BUxXGqqvN7JdQ0zVbt2teZ8zRbJ5cDD6Fv_symvyClVlcVRq7Td6YydvKWO9SZVK1hANO1eiHWNBHXKqIFnc5xBLJ5jEsPuX0jrwZzZTw_blekd_3d79uvtcPP7_9uPn6UFtORa5FJxiXjjPRWWHoiIMdzTB2ksEggLO-c0aqwTqFFlBh33auF8oqZ62gyrVX5PNp7y6W2zFlPftkcZrMgmGftOx7zjrV_xekiou2Z1BAdgJtDClFHPUu-tnEJ01BH6XorT5K0UcpGjpdpJTQx_P2_TCje4mcLRTg0xkwyZppjGaxPr1wfZEKsi3clxOH5WkHj1En63Gx6Hx5c9Yu-H_d8QxKqqxZ</recordid><startdate>20061015</startdate><enddate>20061015</enddate><creator>Malovichko, Olga L.</creator><creator>Petrus, Anna S.</creator><creator>Krysko, Andrei A.</creator><creator>Kabanova, Tatyana A.</creator><creator>Andronati, Sergei A.</creator><creator>Karaseva, Tamara L.</creator><creator>Kiriyak, Anna V.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20061015</creationdate><title>Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists</title><author>Malovichko, Olga L. ; Petrus, Anna S. ; Krysko, Andrei A. ; Kabanova, Tatyana A. ; Andronati, Sergei A. ; Karaseva, Tamara L. ; Kiriyak, Anna V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-575246d4257c5a1febcfabf7620b504287da69bcd9ec0e9e837d859c9dcc519d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>1,2,3,4-Tetrahydroisoquinoline</topic><topic>Binding, Competitive - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Drug Evaluation, Preclinical</topic><topic>Fibrinogen receptor antagonists</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Mimicry</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Phthalic Acids - chemical synthesis</topic><topic>Phthalic Acids - chemistry</topic><topic>Phthalic Acids - pharmacology</topic><topic>Platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - chemical synthesis</topic><topic>Platelet Aggregation Inhibitors - chemistry</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - drug effects</topic><topic>Protein Binding - drug effects</topic><topic>Receptors, Fibrinogen - antagonists & inhibitors</topic><topic>RGD mimetics</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>α IIbβ 3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malovichko, Olga L.</creatorcontrib><creatorcontrib>Petrus, Anna S.</creatorcontrib><creatorcontrib>Krysko, Andrei A.</creatorcontrib><creatorcontrib>Kabanova, Tatyana A.</creatorcontrib><creatorcontrib>Andronati, Sergei A.</creatorcontrib><creatorcontrib>Karaseva, Tamara L.</creatorcontrib><creatorcontrib>Kiriyak, Anna V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malovichko, Olga L.</au><au>Petrus, Anna S.</au><au>Krysko, Andrei A.</au><au>Kabanova, Tatyana A.</au><au>Andronati, Sergei A.</au><au>Karaseva, Tamara L.</au><au>Kiriyak, Anna V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2006-10-15</date><risdate>2006</risdate><volume>16</volume><issue>20</issue><spage>5294</spage><epage>5297</epage><pages>5294-5297</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>The synthesis of the novel fibrinogen receptor antagonists
9a–
9h is reported.
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to α
IIbβ
3 on washed human platelets.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16919941</pmid><doi>10.1016/j.bmcl.2006.07.090</doi><tpages>4</tpages></addata></record> |
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| subjects | 1,2,3,4-Tetrahydroisoquinoline Binding, Competitive - drug effects Biological and medical sciences Biological Assay Blood. Blood coagulation. Reticuloendothelial system Drug Evaluation, Preclinical Fibrinogen receptor antagonists Humans Medical sciences Molecular Mimicry Molecular Structure Pharmacology. Drug treatments Phthalic Acids - chemical synthesis Phthalic Acids - chemistry Phthalic Acids - pharmacology Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - drug effects Protein Binding - drug effects Receptors, Fibrinogen - antagonists & inhibitors RGD mimetics Stereoisomerism Structure-Activity Relationship α IIbβ 3 |
| title | Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists |
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