Comprehensive two-dimensional liquid chromatography with on-line Fourier-transform-infrared-spectroscopy detection for the characterization of copolymers
The on-line coupling of comprehensive two-dimensional liquid chromatography (liquid chromatography × size-exclusion chromatography, LC × SEC) and infrared (IR) spectroscopy has been realized by means of an IR flow cell. The system has been assessed by the functional-group analysis of a series of sty...
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| Veröffentlicht in: | Journal of Chromatography A 2005-12, Vol.1098 (1), p.104-110 |
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| container_title | Journal of Chromatography A |
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| creator | Kok, S.J. Hankemeier, Th Schoenmakers, P.J. |
| description | The on-line coupling of comprehensive two-dimensional liquid chromatography (liquid chromatography
×
size-exclusion chromatography, LC
×
SEC) and infrared (IR) spectroscopy has been realized by means of an IR flow cell. The system has been assessed by the functional-group analysis of a series of styrene-methylacrylate (SMA) copolymers with varying styrene content. Ultraviolet (UV) detection was used as a detection technique to verify the detection with IR. The LC
×
SEC–IR functional-group contour plots (comprehensive chromatograms) obtained for styrene were in agreement with the contour plots constructed from the UV signal. In addition, contour plots can be obtained from non-UV-active groups. One such plot, for the carbonyl-stretching vibration of methylacrylate (MA), is shown. Selective detection of MA proved possible using flow cell IR detection. The combination of the contour plots for styrene and MA allowed a full characterization of the copolymer and it was revealed that the present series of SMA copolymers exhibited homogeneous chemical-composition distributions (CCDs). In addition, commercially available fast-SEC columns have been assessed in this study with respect to their potential to serve as second-dimension separation columns. |
| doi_str_mv | 10.1016/j.chroma.2005.08.058 |
| format | Article |
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×
size-exclusion chromatography, LC
×
SEC) and infrared (IR) spectroscopy has been realized by means of an IR flow cell. The system has been assessed by the functional-group analysis of a series of styrene-methylacrylate (SMA) copolymers with varying styrene content. Ultraviolet (UV) detection was used as a detection technique to verify the detection with IR. The LC
×
SEC–IR functional-group contour plots (comprehensive chromatograms) obtained for styrene were in agreement with the contour plots constructed from the UV signal. In addition, contour plots can be obtained from non-UV-active groups. One such plot, for the carbonyl-stretching vibration of methylacrylate (MA), is shown. Selective detection of MA proved possible using flow cell IR detection. The combination of the contour plots for styrene and MA allowed a full characterization of the copolymer and it was revealed that the present series of SMA copolymers exhibited homogeneous chemical-composition distributions (CCDs). In addition, commercially available fast-SEC columns have been assessed in this study with respect to their potential to serve as second-dimension separation columns.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2005.08.058</identifier><identifier>PMID: 16314165</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acrylates - chemistry ; Analytical chemistry ; Applied sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, Liquid - methods ; Copolymers ; Exact sciences and technology ; Flow cell ; Fourier-transform-infrared-spectroscopy ; Organic polymers ; Other chromatographic methods ; Physicochemistry of polymers ; Polymer analysis ; Polymers - analysis ; Polymers - chemistry ; Properties and characterization ; Reproducibility of Results ; Sensitivity and Specificity ; Size-exclusion chromatography ; Solvent-elimination interfaces ; Solvents - chemistry ; Spectroscopy, Fourier Transform Infrared - methods ; Structure, morphology and analysis ; Styrenes - chemistry ; Two-dimensional liquid chromatography</subject><ispartof>Journal of Chromatography A, 2005-12, Vol.1098 (1), p.104-110</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-e216d7c6b25c4594bd10c7a46fca9ef3ab5a8046ee2f8618ca1f71c3b62cff4b3</citedby><cites>FETCH-LOGICAL-c390t-e216d7c6b25c4594bd10c7a46fca9ef3ab5a8046ee2f8618ca1f71c3b62cff4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2005.08.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17306926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16314165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kok, S.J.</creatorcontrib><creatorcontrib>Hankemeier, Th</creatorcontrib><creatorcontrib>Schoenmakers, P.J.</creatorcontrib><title>Comprehensive two-dimensional liquid chromatography with on-line Fourier-transform-infrared-spectroscopy detection for the characterization of copolymers</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>The on-line coupling of comprehensive two-dimensional liquid chromatography (liquid chromatography
×
size-exclusion chromatography, LC
×
SEC) and infrared (IR) spectroscopy has been realized by means of an IR flow cell. The system has been assessed by the functional-group analysis of a series of styrene-methylacrylate (SMA) copolymers with varying styrene content. Ultraviolet (UV) detection was used as a detection technique to verify the detection with IR. The LC
×
SEC–IR functional-group contour plots (comprehensive chromatograms) obtained for styrene were in agreement with the contour plots constructed from the UV signal. In addition, contour plots can be obtained from non-UV-active groups. One such plot, for the carbonyl-stretching vibration of methylacrylate (MA), is shown. Selective detection of MA proved possible using flow cell IR detection. The combination of the contour plots for styrene and MA allowed a full characterization of the copolymer and it was revealed that the present series of SMA copolymers exhibited homogeneous chemical-composition distributions (CCDs). In addition, commercially available fast-SEC columns have been assessed in this study with respect to their potential to serve as second-dimension separation columns.</description><subject>Acrylates - chemistry</subject><subject>Analytical chemistry</subject><subject>Applied sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, Liquid - methods</subject><subject>Copolymers</subject><subject>Exact sciences and technology</subject><subject>Flow cell</subject><subject>Fourier-transform-infrared-spectroscopy</subject><subject>Organic polymers</subject><subject>Other chromatographic methods</subject><subject>Physicochemistry of polymers</subject><subject>Polymer analysis</subject><subject>Polymers - analysis</subject><subject>Polymers - chemistry</subject><subject>Properties and characterization</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Size-exclusion chromatography</subject><subject>Solvent-elimination interfaces</subject><subject>Solvents - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Structure, morphology and analysis</subject><subject>Styrenes - chemistry</subject><subject>Two-dimensional liquid chromatography</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGO1SAUhllonHH0DYxhozsq0Ja2GxNz46jJJG50TSgcLDctdIDO5Pomvq1ce5PZuSInfOc_5_w_Qm8YrRhl4sOx0lMMi6o4pW1F-4q2_TN0TSlnZBBdfYVepnSklHW04y_QFRM1a5hor9GfQ1jWCBP45B4A58dAjFvOVfBqxrO735zBu3oOv6JapxN-dHnCwZPZecC3YYsOIslR-WRDXIjzNqoIhqQVdI4h6bCesIFcqiKLC4TzBEVVRaUzRPdb_fsIFhc0zKcFYnqFnls1J3h9eW_Qz9vPPw5fyd33L98On-6IrgeaCXAmTKfFyFvdtEMzGkZ1pxphtRrA1mpsVU8bAcBtL1ivFbMd0_UouLa2Gesb9H7XXWO43yBlubikYZ6Vh7AlKfq-4ZyKAjY7qMtJKYKVa3SLiifJqDzHII9yN0qeY5C0lyWG0vb2or-NC5inpksGBXh3AVTSai7eee3SE9fVVAz8PP_jzkFx46FYLpN24DUYF4uz0gT3_03-Aj2KsHU</recordid><startdate>20051209</startdate><enddate>20051209</enddate><creator>Kok, S.J.</creator><creator>Hankemeier, Th</creator><creator>Schoenmakers, P.J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051209</creationdate><title>Comprehensive two-dimensional liquid chromatography with on-line Fourier-transform-infrared-spectroscopy detection for the characterization of copolymers</title><author>Kok, S.J. ; Hankemeier, Th ; Schoenmakers, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-e216d7c6b25c4594bd10c7a46fca9ef3ab5a8046ee2f8618ca1f71c3b62cff4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acrylates - chemistry</topic><topic>Analytical chemistry</topic><topic>Applied sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, Liquid - methods</topic><topic>Copolymers</topic><topic>Exact sciences and technology</topic><topic>Flow cell</topic><topic>Fourier-transform-infrared-spectroscopy</topic><topic>Organic polymers</topic><topic>Other chromatographic methods</topic><topic>Physicochemistry of polymers</topic><topic>Polymer analysis</topic><topic>Polymers - analysis</topic><topic>Polymers - chemistry</topic><topic>Properties and characterization</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Size-exclusion chromatography</topic><topic>Solvent-elimination interfaces</topic><topic>Solvents - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared - methods</topic><topic>Structure, morphology and analysis</topic><topic>Styrenes - chemistry</topic><topic>Two-dimensional liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kok, S.J.</creatorcontrib><creatorcontrib>Hankemeier, Th</creatorcontrib><creatorcontrib>Schoenmakers, P.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kok, S.J.</au><au>Hankemeier, Th</au><au>Schoenmakers, P.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive two-dimensional liquid chromatography with on-line Fourier-transform-infrared-spectroscopy detection for the characterization of copolymers</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2005-12-09</date><risdate>2005</risdate><volume>1098</volume><issue>1</issue><spage>104</spage><epage>110</epage><pages>104-110</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>The on-line coupling of comprehensive two-dimensional liquid chromatography (liquid chromatography
×
size-exclusion chromatography, LC
×
SEC) and infrared (IR) spectroscopy has been realized by means of an IR flow cell. The system has been assessed by the functional-group analysis of a series of styrene-methylacrylate (SMA) copolymers with varying styrene content. Ultraviolet (UV) detection was used as a detection technique to verify the detection with IR. The LC
×
SEC–IR functional-group contour plots (comprehensive chromatograms) obtained for styrene were in agreement with the contour plots constructed from the UV signal. In addition, contour plots can be obtained from non-UV-active groups. One such plot, for the carbonyl-stretching vibration of methylacrylate (MA), is shown. Selective detection of MA proved possible using flow cell IR detection. The combination of the contour plots for styrene and MA allowed a full characterization of the copolymer and it was revealed that the present series of SMA copolymers exhibited homogeneous chemical-composition distributions (CCDs). In addition, commercially available fast-SEC columns have been assessed in this study with respect to their potential to serve as second-dimension separation columns.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16314165</pmid><doi>10.1016/j.chroma.2005.08.058</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of Chromatography A, 2005-12, Vol.1098 (1), p.104-110 |
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| subjects | Acrylates - chemistry Analytical chemistry Applied sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - methods Copolymers Exact sciences and technology Flow cell Fourier-transform-infrared-spectroscopy Organic polymers Other chromatographic methods Physicochemistry of polymers Polymer analysis Polymers - analysis Polymers - chemistry Properties and characterization Reproducibility of Results Sensitivity and Specificity Size-exclusion chromatography Solvent-elimination interfaces Solvents - chemistry Spectroscopy, Fourier Transform Infrared - methods Structure, morphology and analysis Styrenes - chemistry Two-dimensional liquid chromatography |
| title | Comprehensive two-dimensional liquid chromatography with on-line Fourier-transform-infrared-spectroscopy detection for the characterization of copolymers |
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