Somatic Activation of KIT in Distinct Subtypes of Melanoma

Melanomas on mucosal membranes, acral skin (soles, palms, and nail bed), and skin with chronic sun-induced damage have infrequent mutations in BRAF and NRAS, genes within the mitogen-activated protein (MAP) kinase pathway commonly mutated in melanomas on intermittently sun-exposed skin. This raises...

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Veröffentlicht in:	Journal of clinical oncology 2006-09, Vol.24 (26), p.4340-4346
Hauptverfasser:	CURTIN, John A, BUSAM, Klaus, PINKEL, Daniel, BASTION, Boris C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - therapeutic use Benzamides Biological and medical sciences Biomarkers, Tumor - metabolism Dermatology Female Gene Expression Regulation, Neoplastic Humans Imatinib Mesylate Immunohistochemistry Male Medical sciences Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Microarray Analysis Middle Aged Nucleic Acid Hybridization Piperazines - therapeutic use Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - therapeutic use Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Tumors Tumors of the skin and soft tissue. Premalignant lesions
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