Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Mutations affecting the activity of the Wnt co-receptors LRP5 and LRP6 that cause alterations in skeletal biology confirmed the involvement of Wnt signaling in bone formation. We evaluated the potential role of Dkk1, an inhibitor of LRP5/6 activity, in bone formation by examining the normal expressi...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2006-10, Vol.39 (4), p.754-766
Hauptverfasser:	Li, Ji, Sarosi, Ildiko, Cattley, Russell C., Pretorius, James, Asuncion, Frank, Grisanti, Mario, Morony, Sean, Adamu, Stephen, Geng, Zhaopo, Qiu, Wanrong, Kostenuik, Paul, Lacey, David L., Simonet, W. Scott, Bolon, Brad, Qian, Xueming, Shalhoub, Victoria, Ominsky, Michael S., Zhu Ke, Hua, Li, Xiaodong, Richards, William G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Bone Density Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - metabolism Bone Diseases, Metabolic - physiopathology Bone mass Cells, Cultured Dickkopf-1 Diseases of the osteoarticular system Embryo, Mammalian - metabolism Expression Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Developmental Humans In Situ Hybridization Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - physiology LDL-Receptor Related Proteins - metabolism Male Medical sciences Mice Mice, Transgenic Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - blood Osteogenesis - genetics Osteogenesis - physiology Osteoporosis Osteoporosis. Osteomalacia. Paget disease Pregnancy Rats Recombinant Proteins - metabolism Signal Transduction - physiology Transgenic Vertebrates: anatomy and physiology, studies on body, several organs or systems Wnt Proteins - metabolism Wnt Proteins - physiology
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