Molecular models of protein kinase 6 from Plasmodium falciparum
Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular modeling 2005-12, Vol.12 (1), p.42-48 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 48 |
|---|---|
| container_issue | 1 |
| container_start_page | 42 |
| container_title | Journal of molecular modeling |
| container_volume | 12 |
| creator | Manhani, Karisa Karla Arcuri, Helen Andrade da Silveira, Nelson José Freitas Uchôa, Hugo Brandão de Azevedo, Jr, Walter Filgueira Canduri, Fernanda |
| description | Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria. |
| doi_str_mv | 10.1007/s00894-005-0002-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68841067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68841067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-aab4571112b52f21d2e72ef3983a54396dbbb402333cacc5b754528338898d443</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo7rLuD_AiOXmLzuSr6Ulk8QtW9KDnkKYpVNvtmrQH_71Zd8Gjh2EYeN6X4SHkHOEKAYrrBGBKyQBUHuAMj8gcSmmYAi6OyRw1AuOlhBlZpvSRGeRKK85PyQw1lNqAnpOb56ELfupcpP1Qhy7RoaHbOIyh3dDPduNSoJo2cejpa-dSZtqpp43rfLt1cerPyEk-Ulge9oK839-9rR7Z-uXhaXW7Zl4IGJlzlVQFIvJK8YZjzUPBQyNKI5ySotR1VVUyPy6Ed96rqlBScSOEMaWppRQLcrnvzb99TSGNtm-TD13nNmGYktXGSARd_AtiwQWY30bcgz4OKcXQ2G1sexe_LYLdGbZ7wzYbtjvDFnPm4lA-VX2o_xIHn-IHKbl0VA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17230844</pqid></control><display><type>article</type><title>Molecular models of protein kinase 6 from Plasmodium falciparum</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Manhani, Karisa Karla ; Arcuri, Helen Andrade ; da Silveira, Nelson José Freitas ; Uchôa, Hugo Brandão ; de Azevedo, Jr, Walter Filgueira ; Canduri, Fernanda</creator><creatorcontrib>Manhani, Karisa Karla ; Arcuri, Helen Andrade ; da Silveira, Nelson José Freitas ; Uchôa, Hugo Brandão ; de Azevedo, Jr, Walter Filgueira ; Canduri, Fernanda</creatorcontrib><description>Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.</description><identifier>ISSN: 1610-2940</identifier><identifier>EISSN: 0948-5023</identifier><identifier>DOI: 10.1007/s00894-005-0002-1</identifier><identifier>PMID: 16096806</identifier><language>eng</language><publisher>Germany</publisher><subject>Amino Acid Sequence ; Animals ; Binding Sites ; Conserved Sequence ; Cyclin-Dependent Kinases - chemistry ; Cyclin-Dependent Kinases - metabolism ; Hydrogen Bonding ; Kinetin - chemistry ; Kinetin - pharmacology ; Mitogen-Activated Protein Kinases - chemistry ; Mitogen-Activated Protein Kinases - metabolism ; Models, Molecular ; Molecular Sequence Data ; Plasmodium falciparum ; Plasmodium falciparum - enzymology ; Protein Kinase Inhibitors - chemistry ; Protein Kinase Inhibitors - pharmacology ; Protein Structure, Tertiary ; Protozoan Proteins - chemistry ; Protozoan Proteins - metabolism ; Purines - chemistry ; Purines - pharmacology ; Sequence Alignment ; Static Electricity</subject><ispartof>Journal of molecular modeling, 2005-12, Vol.12 (1), p.42-48</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-aab4571112b52f21d2e72ef3983a54396dbbb402333cacc5b754528338898d443</citedby><cites>FETCH-LOGICAL-c330t-aab4571112b52f21d2e72ef3983a54396dbbb402333cacc5b754528338898d443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16096806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manhani, Karisa Karla</creatorcontrib><creatorcontrib>Arcuri, Helen Andrade</creatorcontrib><creatorcontrib>da Silveira, Nelson José Freitas</creatorcontrib><creatorcontrib>Uchôa, Hugo Brandão</creatorcontrib><creatorcontrib>de Azevedo, Jr, Walter Filgueira</creatorcontrib><creatorcontrib>Canduri, Fernanda</creatorcontrib><title>Molecular models of protein kinase 6 from Plasmodium falciparum</title><title>Journal of molecular modeling</title><addtitle>J Mol Model</addtitle><description>Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Binding Sites</subject><subject>Conserved Sequence</subject><subject>Cyclin-Dependent Kinases - chemistry</subject><subject>Cyclin-Dependent Kinases - metabolism</subject><subject>Hydrogen Bonding</subject><subject>Kinetin - chemistry</subject><subject>Kinetin - pharmacology</subject><subject>Mitogen-Activated Protein Kinases - chemistry</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - enzymology</subject><subject>Protein Kinase Inhibitors - chemistry</subject><subject>Protein Kinase Inhibitors - pharmacology</subject><subject>Protein Structure, Tertiary</subject><subject>Protozoan Proteins - chemistry</subject><subject>Protozoan Proteins - metabolism</subject><subject>Purines - chemistry</subject><subject>Purines - pharmacology</subject><subject>Sequence Alignment</subject><subject>Static Electricity</subject><issn>1610-2940</issn><issn>0948-5023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rLuD_AiOXmLzuSr6Ulk8QtW9KDnkKYpVNvtmrQH_71Zd8Gjh2EYeN6X4SHkHOEKAYrrBGBKyQBUHuAMj8gcSmmYAi6OyRw1AuOlhBlZpvSRGeRKK85PyQw1lNqAnpOb56ELfupcpP1Qhy7RoaHbOIyh3dDPduNSoJo2cejpa-dSZtqpp43rfLt1cerPyEk-Ulge9oK839-9rR7Z-uXhaXW7Zl4IGJlzlVQFIvJK8YZjzUPBQyNKI5ySotR1VVUyPy6Ed96rqlBScSOEMaWppRQLcrnvzb99TSGNtm-TD13nNmGYktXGSARd_AtiwQWY30bcgz4OKcXQ2G1sexe_LYLdGbZ7wzYbtjvDFnPm4lA-VX2o_xIHn-IHKbl0VA</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Manhani, Karisa Karla</creator><creator>Arcuri, Helen Andrade</creator><creator>da Silveira, Nelson José Freitas</creator><creator>Uchôa, Hugo Brandão</creator><creator>de Azevedo, Jr, Walter Filgueira</creator><creator>Canduri, Fernanda</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Molecular models of protein kinase 6 from Plasmodium falciparum</title><author>Manhani, Karisa Karla ; Arcuri, Helen Andrade ; da Silveira, Nelson José Freitas ; Uchôa, Hugo Brandão ; de Azevedo, Jr, Walter Filgueira ; Canduri, Fernanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-aab4571112b52f21d2e72ef3983a54396dbbb402333cacc5b754528338898d443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Binding Sites</topic><topic>Conserved Sequence</topic><topic>Cyclin-Dependent Kinases - chemistry</topic><topic>Cyclin-Dependent Kinases - metabolism</topic><topic>Hydrogen Bonding</topic><topic>Kinetin - chemistry</topic><topic>Kinetin - pharmacology</topic><topic>Mitogen-Activated Protein Kinases - chemistry</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Models, Molecular</topic><topic>Molecular Sequence Data</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - enzymology</topic><topic>Protein Kinase Inhibitors - chemistry</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Protein Structure, Tertiary</topic><topic>Protozoan Proteins - chemistry</topic><topic>Protozoan Proteins - metabolism</topic><topic>Purines - chemistry</topic><topic>Purines - pharmacology</topic><topic>Sequence Alignment</topic><topic>Static Electricity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manhani, Karisa Karla</creatorcontrib><creatorcontrib>Arcuri, Helen Andrade</creatorcontrib><creatorcontrib>da Silveira, Nelson José Freitas</creatorcontrib><creatorcontrib>Uchôa, Hugo Brandão</creatorcontrib><creatorcontrib>de Azevedo, Jr, Walter Filgueira</creatorcontrib><creatorcontrib>Canduri, Fernanda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular modeling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manhani, Karisa Karla</au><au>Arcuri, Helen Andrade</au><au>da Silveira, Nelson José Freitas</au><au>Uchôa, Hugo Brandão</au><au>de Azevedo, Jr, Walter Filgueira</au><au>Canduri, Fernanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular models of protein kinase 6 from Plasmodium falciparum</atitle><jtitle>Journal of molecular modeling</jtitle><addtitle>J Mol Model</addtitle><date>2005-12</date><risdate>2005</risdate><volume>12</volume><issue>1</issue><spage>42</spage><epage>48</epage><pages>42-48</pages><issn>1610-2940</issn><eissn>0948-5023</eissn><abstract>Cyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.</abstract><cop>Germany</cop><pmid>16096806</pmid><doi>10.1007/s00894-005-0002-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1610-2940 |
| ispartof | Journal of molecular modeling, 2005-12, Vol.12 (1), p.42-48 |
| issn | 1610-2940 0948-5023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68841067 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Amino Acid Sequence Animals Binding Sites Conserved Sequence Cyclin-Dependent Kinases - chemistry Cyclin-Dependent Kinases - metabolism Hydrogen Bonding Kinetin - chemistry Kinetin - pharmacology Mitogen-Activated Protein Kinases - chemistry Mitogen-Activated Protein Kinases - metabolism Models, Molecular Molecular Sequence Data Plasmodium falciparum Plasmodium falciparum - enzymology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Structure, Tertiary Protozoan Proteins - chemistry Protozoan Proteins - metabolism Purines - chemistry Purines - pharmacology Sequence Alignment Static Electricity |
| title | Molecular models of protein kinase 6 from Plasmodium falciparum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A13%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20models%20of%20protein%20kinase%206%20from%20Plasmodium%20falciparum&rft.jtitle=Journal%20of%20molecular%20modeling&rft.au=Manhani,%20Karisa%20Karla&rft.date=2005-12&rft.volume=12&rft.issue=1&rft.spage=42&rft.epage=48&rft.pages=42-48&rft.issn=1610-2940&rft.eissn=0948-5023&rft_id=info:doi/10.1007/s00894-005-0002-1&rft_dat=%3Cproquest_cross%3E68841067%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17230844&rft_id=info:pmid/16096806&rfr_iscdi=true |