Protection of ischemic brain cells is dependent on astrocyte-derived growth factors and their receptors

An in vitro ischemia model (oxygen, glucose, and serum deprivation) is used to investigate the possible cellular and molecular mechanisms responsible for cerebral ischemia. We have previously demonstrated that supernatants derived from ischemic microglia can protect ischemic brain cells by releasing...

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Veröffentlicht in:	Experimental neurology 2006-09, Vol.201 (1), p.225-233
Hauptverfasser:	Lin, Chi-Hsin, Cheng, Fu-Chou, Lu, Yen-Zhen, Chu, Lan-Feng, Wang, Chen-Hsuan, Hsueh, Chi-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - secretion Biological and medical sciences Blotting, Western Brain - cytology Brain - drug effects Brain - metabolism Cell Hypoxia Cells, Cultured Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Development. Senescence. Regeneration. Transplantation Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology GDNF Glial Cell Line-Derived Neurotrophic Factor - pharmacology Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Growth Substances - pharmacology In vitro ischemia Medical sciences Microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Neurology Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotrophin 3 - pharmacology NT-3 Rats Rats, Sprague-Dawley Receptor, trkC - metabolism Receptors, Growth Factor - metabolism Receptors, Transforming Growth Factor beta - metabolism TGF-β1 Time Factors Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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