Promoter Polymorphism of the Anion-Exchange Protein 1 Associated with Severe Malarial Anemia and Fatality

The anion-exchange protein 1 (AE1 or band 3) is involved in the erythrocyte invasion of the malaria parasite Plasmodium falciparum the adhesion of infected erythrocytes to endothelial cells, and the regulation of acid-base homeostasis, which is a critical factor for human survival in severe malaria....

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Veröffentlicht in:	The Journal of infectious diseases 2006-10, Vol.194 (7), p.949-957
Hauptverfasser:	Kalckreuth, Vera von, Evans, Jennifer A., Timmann, Christian, Kuhn, Daniela, Agbenyega, Tsiri, Horstmann, Rolf D., May, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Adolescent Anemia Anemia - genetics Anemia - mortality Anemia - parasitology Anemia - physiopathology Animals Anion Exchange Protein 1, Erythrocyte - genetics Biological and medical sciences Blood Case-Control Studies Cell Line Cell membranes Cerebral malaria Child Child, Preschool Erythrocytes Female Fluorescence Resonance Energy Transfer Fundamental and applied biological sciences. Psychology Genetic mutation Genotypes Health outcomes Human protozoal diseases Humans Infant Infectious diseases Malaria Malaria, Falciparum - genetics Malaria, Falciparum - mortality Malaria, Falciparum - parasitology Malaria, Falciparum - physiopathology Male Medical sciences Microbiology Parasites Parasitic diseases Plasmodium falciparum Polymorphism, Single Nucleotide Promoter Regions, Genetic Protozoal diseases Severity of Illness Index
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