The dissociation of the Fgf-feedback loop controls the limbless state of the neck
In tetrapods, limbs develop at two specific positions along the anteroposterior axis of the embryo, whereas other regions of the embryo, most prominently the neck and the flank, are limbless. However, the flank can generate an ectopic limb when the Fgf-feedback loop crucial for the initiation of lim...
Gespeichert in:
Veröffentlicht in: | Development (Cambridge) 2005-12, Vol.132 (24), p.5553-5564 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 5564 |
---|---|
container_issue | 24 |
container_start_page | 5553 |
container_title | Development (Cambridge) |
container_volume | 132 |
creator | Lours, Corinne Dietrich, Susanne |
description | In tetrapods, limbs develop at two specific positions along the anteroposterior axis of the embryo, whereas other regions of the embryo, most prominently the neck and the flank, are limbless. However, the flank can generate an ectopic limb when the Fgf-feedback loop crucial for the initiation of limb budding is activated. Thus, despite its limblessness, the flank is a limb-competent area. Using the chick embryo as model, we investigated whether the neck, as the flank, has the competence to form a limb, and what mechanism may regulate its limblessness. We show that forelimb lateral mesoderm plus ectoderm grafted into the neck can continue limb development, suggesting that the neck does not actively inhibit this process. However, neck tissues themselves do not support or take part in limb formation. Hence, the neck is limb-incompetent. This is due to the dismantling of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm. |
doi_str_mv | 10.1242/dev.02164 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68839552</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17432040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-d4d0dbaa0af3f40ec37cbbc18548b59b2c393cfe59ec16ad618da582e20e1e453</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQQBdRbK0e_AOSk-AhdWc_kuxRxKpQEKGel81m0q7ddGs2Vfz3ph_i0dPAzJt3eIRcAh0DE-y2ws8xZZCJIzIEkeepAqaOyZAqSVNQCgbkLMZ3SinP8vyUDCDjIERRDMnrbIFJ5WIM1pnOhVUS6qTrd5N5ndaIVWnsMvEhrBMbVl0bfNydvWtKjzEmsTMd_j6t0C7PyUltfMSLwxyRt8nD7P4pnb48Pt_fTVMrQHVpJSrayw01Na8FRctzW5YWCimKUqqSWa64rVEqtJCZKoOiMrJgyCgCCslH5HrvXbfhY4Ox042LFr03KwybqLOi4EpK9i8IueCMCtqDN3vQtiHGFmu9bl1j2m8NVG9D6z603oXu2auDdFM2WP2Rh7I9MN4DCzdffLkWdemCD3MXu7j1oA9rDZxpJrSUkvMfb1KJbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17432040</pqid></control><display><type>article</type><title>The dissociation of the Fgf-feedback loop controls the limbless state of the neck</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Lours, Corinne ; Dietrich, Susanne</creator><creatorcontrib>Lours, Corinne ; Dietrich, Susanne</creatorcontrib><description>In tetrapods, limbs develop at two specific positions along the anteroposterior axis of the embryo, whereas other regions of the embryo, most prominently the neck and the flank, are limbless. However, the flank can generate an ectopic limb when the Fgf-feedback loop crucial for the initiation of limb budding is activated. Thus, despite its limblessness, the flank is a limb-competent area. Using the chick embryo as model, we investigated whether the neck, as the flank, has the competence to form a limb, and what mechanism may regulate its limblessness. We show that forelimb lateral mesoderm plus ectoderm grafted into the neck can continue limb development, suggesting that the neck does not actively inhibit this process. However, neck tissues themselves do not support or take part in limb formation. Hence, the neck is limb-incompetent. This is due to the dismantling of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.02164</identifier><identifier>PMID: 16314488</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Animals ; Chick Embryo ; Ectoderm - physiology ; Ectoderm - transplantation ; Extremities - embryology ; Feedback, Physiological ; Fibroblast Growth Factor 10 - physiology ; Fibroblast Growth Factor 8 - physiology ; Fibroblast Growth Factors - physiology ; MAP Kinase Signaling System - physiology ; Mesoderm - metabolism ; Mesoderm - transplantation ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - metabolism ; Neck - embryology ; Phosphorylation ; Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis ; Signal Transduction</subject><ispartof>Development (Cambridge), 2005-12, Vol.132 (24), p.5553-5564</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-d4d0dbaa0af3f40ec37cbbc18548b59b2c393cfe59ec16ad618da582e20e1e453</citedby><cites>FETCH-LOGICAL-c419t-d4d0dbaa0af3f40ec37cbbc18548b59b2c393cfe59ec16ad618da582e20e1e453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16314488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lours, Corinne</creatorcontrib><creatorcontrib>Dietrich, Susanne</creatorcontrib><title>The dissociation of the Fgf-feedback loop controls the limbless state of the neck</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>In tetrapods, limbs develop at two specific positions along the anteroposterior axis of the embryo, whereas other regions of the embryo, most prominently the neck and the flank, are limbless. However, the flank can generate an ectopic limb when the Fgf-feedback loop crucial for the initiation of limb budding is activated. Thus, despite its limblessness, the flank is a limb-competent area. Using the chick embryo as model, we investigated whether the neck, as the flank, has the competence to form a limb, and what mechanism may regulate its limblessness. We show that forelimb lateral mesoderm plus ectoderm grafted into the neck can continue limb development, suggesting that the neck does not actively inhibit this process. However, neck tissues themselves do not support or take part in limb formation. Hence, the neck is limb-incompetent. This is due to the dismantling of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm.</description><subject>Animals</subject><subject>Chick Embryo</subject><subject>Ectoderm - physiology</subject><subject>Ectoderm - transplantation</subject><subject>Extremities - embryology</subject><subject>Feedback, Physiological</subject><subject>Fibroblast Growth Factor 10 - physiology</subject><subject>Fibroblast Growth Factor 8 - physiology</subject><subject>Fibroblast Growth Factors - physiology</subject><subject>MAP Kinase Signaling System - physiology</subject><subject>Mesoderm - metabolism</subject><subject>Mesoderm - transplantation</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3 - metabolism</subject><subject>Neck - embryology</subject><subject>Phosphorylation</subject><subject>Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis</subject><subject>Signal Transduction</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQQBdRbK0e_AOSk-AhdWc_kuxRxKpQEKGel81m0q7ddGs2Vfz3ph_i0dPAzJt3eIRcAh0DE-y2ws8xZZCJIzIEkeepAqaOyZAqSVNQCgbkLMZ3SinP8vyUDCDjIERRDMnrbIFJ5WIM1pnOhVUS6qTrd5N5ndaIVWnsMvEhrBMbVl0bfNydvWtKjzEmsTMd_j6t0C7PyUltfMSLwxyRt8nD7P4pnb48Pt_fTVMrQHVpJSrayw01Na8FRctzW5YWCimKUqqSWa64rVEqtJCZKoOiMrJgyCgCCslH5HrvXbfhY4Ox042LFr03KwybqLOi4EpK9i8IueCMCtqDN3vQtiHGFmu9bl1j2m8NVG9D6z603oXu2auDdFM2WP2Rh7I9MN4DCzdffLkWdemCD3MXu7j1oA9rDZxpJrSUkvMfb1KJbQ</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Lours, Corinne</creator><creator>Dietrich, Susanne</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>The dissociation of the Fgf-feedback loop controls the limbless state of the neck</title><author>Lours, Corinne ; Dietrich, Susanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-d4d0dbaa0af3f40ec37cbbc18548b59b2c393cfe59ec16ad618da582e20e1e453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Chick Embryo</topic><topic>Ectoderm - physiology</topic><topic>Ectoderm - transplantation</topic><topic>Extremities - embryology</topic><topic>Feedback, Physiological</topic><topic>Fibroblast Growth Factor 10 - physiology</topic><topic>Fibroblast Growth Factor 8 - physiology</topic><topic>Fibroblast Growth Factors - physiology</topic><topic>MAP Kinase Signaling System - physiology</topic><topic>Mesoderm - metabolism</topic><topic>Mesoderm - transplantation</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>Neck - embryology</topic><topic>Phosphorylation</topic><topic>Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lours, Corinne</creatorcontrib><creatorcontrib>Dietrich, Susanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lours, Corinne</au><au>Dietrich, Susanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The dissociation of the Fgf-feedback loop controls the limbless state of the neck</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>132</volume><issue>24</issue><spage>5553</spage><epage>5564</epage><pages>5553-5564</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>In tetrapods, limbs develop at two specific positions along the anteroposterior axis of the embryo, whereas other regions of the embryo, most prominently the neck and the flank, are limbless. However, the flank can generate an ectopic limb when the Fgf-feedback loop crucial for the initiation of limb budding is activated. Thus, despite its limblessness, the flank is a limb-competent area. Using the chick embryo as model, we investigated whether the neck, as the flank, has the competence to form a limb, and what mechanism may regulate its limblessness. We show that forelimb lateral mesoderm plus ectoderm grafted into the neck can continue limb development, suggesting that the neck does not actively inhibit this process. However, neck tissues themselves do not support or take part in limb formation. Hence, the neck is limb-incompetent. This is due to the dismantling of Fgf signalling at distinct points of the MAPK signalling cascade in the neck lateral mesoderm and ectoderm.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>16314488</pmid><doi>10.1242/dev.02164</doi><tpages>12</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0950-1991 |
ispartof | Development (Cambridge), 2005-12, Vol.132 (24), p.5553-5564 |
issn | 0950-1991 1477-9129 |
language | eng |
recordid | cdi_proquest_miscellaneous_68839552 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
subjects | Animals Chick Embryo Ectoderm - physiology Ectoderm - transplantation Extremities - embryology Feedback, Physiological Fibroblast Growth Factor 10 - physiology Fibroblast Growth Factor 8 - physiology Fibroblast Growth Factors - physiology MAP Kinase Signaling System - physiology Mesoderm - metabolism Mesoderm - transplantation Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neck - embryology Phosphorylation Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis Signal Transduction |
title | The dissociation of the Fgf-feedback loop controls the limbless state of the neck |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A41%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20dissociation%20of%20the%20Fgf-feedback%20loop%20controls%20the%20limbless%20state%20of%20the%20neck&rft.jtitle=Development%20(Cambridge)&rft.au=Lours,%20Corinne&rft.date=2005-12-01&rft.volume=132&rft.issue=24&rft.spage=5553&rft.epage=5564&rft.pages=5553-5564&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.02164&rft_dat=%3Cproquest_cross%3E17432040%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17432040&rft_id=info:pmid/16314488&rfr_iscdi=true |