Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry
Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asym...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2005-12, Vol.53 (6), p.959-965 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Agero, Anna Liza C. Benvenuto-Andrade, Cristiane Dusza, Stephen W. Halpern, Allan C. Marghoob, Ashfaq A. |
| description | Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool.
Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.
Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi.
Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.
Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi. |
| doi_str_mv | 10.1016/j.jaad.2005.07.046 |
| format | Article |
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Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.
Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi.
Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.
Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2005.07.046</identifier><identifier>PMID: 16310055</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Dermatology ; Female ; Humans ; Infant ; Infant, Newborn ; Internet ; Male ; Medical sciences ; Melanosis - complications ; Melanosis - diagnosis ; Middle Aged ; Neurocutaneous Syndromes - complications ; Neurocutaneous Syndromes - diagnosis ; Nevus, Pigmented - complications ; Pigmentary diseases of the skin ; Registries ; Skin Neoplasms - complications ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of the American Academy of Dermatology, 2005-12, Vol.53 (6), p.959-965</ispartof><rights>2005 American Academy of Dermatology, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-592d26957bc664e4e11e304e639632ede0919ee5ef465eef986686ef3f49cbd93</citedby><cites>FETCH-LOGICAL-c384t-592d26957bc664e4e11e304e639632ede0919ee5ef465eef986686ef3f49cbd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019096220502308X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17331253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16310055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agero, Anna Liza C.</creatorcontrib><creatorcontrib>Benvenuto-Andrade, Cristiane</creatorcontrib><creatorcontrib>Dusza, Stephen W.</creatorcontrib><creatorcontrib>Halpern, Allan C.</creatorcontrib><creatorcontrib>Marghoob, Ashfaq A.</creatorcontrib><title>Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool.
Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.
Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi.
Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.
Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Internet</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanosis - complications</subject><subject>Melanosis - diagnosis</subject><subject>Middle Aged</subject><subject>Neurocutaneous Syndromes - complications</subject><subject>Neurocutaneous Syndromes - diagnosis</subject><subject>Nevus, Pigmented - complications</subject><subject>Pigmentary diseases of the skin</subject><subject>Registries</subject><subject>Skin Neoplasms - complications</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO0zAUhi0EYsrAC7BA3sAuwZfEiRGbasRlpJHYwNpynZPiKrGLjzMoL8Ez49JK3bGydPT9v47PR8hrzmrOuHp_qA_WDrVgrK1ZV7NGPSEbznRXqa7vnpIN45pVWglxQ14gHhhjupHdc3LDleQl1W7Iny2u8zHH2WbvaIAlRbdkGyAuSGeYbIhuzRE9Uh_osVAQMtLfPv-kk017oC6GPQSf7XTl_1U9-g90SzEvw0rjSJ1FQDqmOFMb6H3IkALkalfGA02w95jT-pI8G-2E8Ory3pIfnz99v_taPXz7cn-3faic7JtctVoMQum22zmlGmiAc5CsASW1kgIGYJprgBbGRrUAo-6V6hWMcmy02w1a3pJ3595jir8WwGxmjw6m6fxzo_peaiGaAooz6FJETDCaY_KzTavhzJwsmIM5WTAnC4Z1plgooTeX9mU3w3CNXM5egLcXwKKz05hscB6vXCclF60s3MczB-UWjx6SQVcEOBh8ApfNEP3_9vgLJ4ypHw</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Agero, Anna Liza C.</creator><creator>Benvenuto-Andrade, Cristiane</creator><creator>Dusza, Stephen W.</creator><creator>Halpern, Allan C.</creator><creator>Marghoob, Ashfaq A.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry</title><author>Agero, Anna Liza C. ; Benvenuto-Andrade, Cristiane ; Dusza, Stephen W. ; Halpern, Allan C. ; Marghoob, Ashfaq A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-592d26957bc664e4e11e304e639632ede0919ee5ef465eef986686ef3f49cbd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Internet</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanosis - complications</topic><topic>Melanosis - diagnosis</topic><topic>Middle Aged</topic><topic>Neurocutaneous Syndromes - complications</topic><topic>Neurocutaneous Syndromes - diagnosis</topic><topic>Nevus, Pigmented - complications</topic><topic>Pigmentary diseases of the skin</topic><topic>Registries</topic><topic>Skin Neoplasms - complications</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agero, Anna Liza C.</creatorcontrib><creatorcontrib>Benvenuto-Andrade, Cristiane</creatorcontrib><creatorcontrib>Dusza, Stephen W.</creatorcontrib><creatorcontrib>Halpern, Allan C.</creatorcontrib><creatorcontrib>Marghoob, Ashfaq A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agero, Anna Liza C.</au><au>Benvenuto-Andrade, Cristiane</au><au>Dusza, Stephen W.</au><au>Halpern, Allan C.</au><au>Marghoob, Ashfaq A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>53</volume><issue>6</issue><spage>959</spage><epage>965</epage><pages>959-965</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool.
Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.
Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi.
Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.
Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16310055</pmid><doi>10.1016/j.jaad.2005.07.046</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Biological and medical sciences Child Child, Preschool Dermatology Female Humans Infant Infant, Newborn Internet Male Medical sciences Melanosis - complications Melanosis - diagnosis Middle Aged Neurocutaneous Syndromes - complications Neurocutaneous Syndromes - diagnosis Nevus, Pigmented - complications Pigmentary diseases of the skin Registries Skin Neoplasms - complications Tumors of the skin and soft tissue. Premalignant lesions |
| title | Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry |
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