Exogenous leptin advances puberty in domestic hen
The present study was undertaken to examine the effect of recombinant chicken leptin administered to fed ad libitum and feed-restricted immature chickens of a layer strain on ovarian development and the timing of sexual maturity. In the first experiment 11-week-old pullets (77 days of age) fed ad li...
Gespeichert in:
| Veröffentlicht in: | Domestic animal endocrinology 2006-10, Vol.31 (3), p.211-226 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 226 |
|---|---|
| container_issue | 3 |
| container_start_page | 211 |
| container_title | Domestic animal endocrinology |
| container_volume | 31 |
| creator | Paczoska-Eliasiewicz, Helena Elzbieta Proszkowiec-Weglarz, Monika Proudman, John Jacek, Tomasz Mika, Maria Sechman, Andrzej Rzasa, Janusz Gertler, Arieh |
| description | The present study was undertaken to examine the effect of recombinant chicken leptin administered to fed ad libitum and feed-restricted immature chickens of a layer strain on ovarian development and the timing of sexual maturity. In the first experiment 11-week-old pullets (77 days of age) fed ad libitum were injected daily with leptin at four dose levels (4, 16, 64 and 256
μg/kg body weight) until sexual maturity (lay of the first egg). Leptin treatment at the highest dose significantly (
P
<
0.05) advanced the onset of puberty (day 116.3
±
1.0) in comparison to controls (day 121.3
±
1.2). The rises of luteinizing hormone, estradiol and progesterone in blood plasma were also advanced by leptin treatment. In the second experiment, both full-fed and feed-restricted pullets (79 days of age) were injected daily with leptin (256
μg/kg body weight). In birds fed ad libitum, exogenous leptin again significantly (
P
<
0.05) advanced first ovipostion (day 118.4
±
1.4 versus day 124.4
±
1.7), while abolishing the significant (
P
<
0.05) delay caused by feed restriction (day 131.5
±
1.6) and restoring the normal onset of sexual maturity (day 125.7
±
1.6). Analysis of the ovaries in 106-day-old pullets revealed that leptin injections advanced follicular development, particularly in birds fed ad libitum, and significantly (
P
<
0.01) reduced follicular apoptosis both in full-fed and feed-restricted birds. In conclusion, we have shown that in female chickens exogenous leptin advances the onset of puberty by attenuation of ovarian apoptosis and enhancement of folliculogenesis. |
| doi_str_mv | 10.1016/j.domaniend.2005.10.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68838967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0739724005002171</els_id><sourcerecordid>68838967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-b158c4c583055c9fe49ac55aa07ad59458311430a624b575ca8b4aa3e317413b3</originalsourceid><addsrcrecordid>eNqFkM1OwzAQhC0EoqXwCpATt5R1bMfOEVX8SZU4QM-W42yLqzYpdoro27NVKzhyGmv3G89qGLvhMObAy7vluOnWrg3YNuMCQNF0THLChtzoKqenPGVD0KLKdSFhwC5SWgKAJvc5G_BSgCi0GTL-8N0tsO22KVvhpg9t5pov13pM2WZbY-x3Gc0oDFMffPaB7SU7m7tVwqujjtjs8eF98pxPX59eJvfT3ItK9HnNlfHSKyNAKV_NUVbOK-UcaNeoStKCcynAlYWslVbemVo6J1BwLbmoxYjdHv7dxO5zS_F2HZLH1cq1SOfa0hhhqlITqA-gj11KEed2E8PaxZ3lYPdt2aX9bcvu29ovSMh5fYzY1mts_nzHegi4OQBz11m3iCHZ2VsBXADnILSpiLg_EEhVfAWMNnnK8diEiL6n4PDvGT-db4dl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68838967</pqid></control><display><type>article</type><title>Exogenous leptin advances puberty in domestic hen</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Paczoska-Eliasiewicz, Helena Elzbieta ; Proszkowiec-Weglarz, Monika ; Proudman, John ; Jacek, Tomasz ; Mika, Maria ; Sechman, Andrzej ; Rzasa, Janusz ; Gertler, Arieh</creator><creatorcontrib>Paczoska-Eliasiewicz, Helena Elzbieta ; Proszkowiec-Weglarz, Monika ; Proudman, John ; Jacek, Tomasz ; Mika, Maria ; Sechman, Andrzej ; Rzasa, Janusz ; Gertler, Arieh</creatorcontrib><description>The present study was undertaken to examine the effect of recombinant chicken leptin administered to fed ad libitum and feed-restricted immature chickens of a layer strain on ovarian development and the timing of sexual maturity. In the first experiment 11-week-old pullets (77 days of age) fed ad libitum were injected daily with leptin at four dose levels (4, 16, 64 and 256
μg/kg body weight) until sexual maturity (lay of the first egg). Leptin treatment at the highest dose significantly (
P
<
0.05) advanced the onset of puberty (day 116.3
±
1.0) in comparison to controls (day 121.3
±
1.2). The rises of luteinizing hormone, estradiol and progesterone in blood plasma were also advanced by leptin treatment. In the second experiment, both full-fed and feed-restricted pullets (79 days of age) were injected daily with leptin (256
μg/kg body weight). In birds fed ad libitum, exogenous leptin again significantly (
P
<
0.05) advanced first ovipostion (day 118.4
±
1.4 versus day 124.4
±
1.7), while abolishing the significant (
P
<
0.05) delay caused by feed restriction (day 131.5
±
1.6) and restoring the normal onset of sexual maturity (day 125.7
±
1.6). Analysis of the ovaries in 106-day-old pullets revealed that leptin injections advanced follicular development, particularly in birds fed ad libitum, and significantly (
P
<
0.01) reduced follicular apoptosis both in full-fed and feed-restricted birds. In conclusion, we have shown that in female chickens exogenous leptin advances the onset of puberty by attenuation of ovarian apoptosis and enhancement of folliculogenesis.</description><identifier>ISSN: 0739-7240</identifier><identifier>EISSN: 1879-0054</identifier><identifier>DOI: 10.1016/j.domaniend.2005.10.005</identifier><identifier>PMID: 16303278</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ad libitum feeding ; age at first egg ; Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Body Weight - drug effects ; Body Weight - physiology ; Chicken ; chickens ; Chickens - physiology ; dose response ; estradiol ; Estradiol - blood ; Female ; Follicular development ; Food Deprivation - physiology ; hens ; hormonal regulation ; hormone secretion ; In Situ Nick-End Labeling - veterinary ; Leptin ; Leptin - pharmacology ; luteinizing hormone ; Luteinizing Hormone - blood ; Ovary ; Ovary - drug effects ; Ovary - physiology ; progesterone ; Progesterone - blood ; Puberty ; puberty onset ; restricted feeding ; Sexual Maturation - drug effects ; Sexual Maturation - physiology ; sexual maturity</subject><ispartof>Domestic animal endocrinology, 2006-10, Vol.31 (3), p.211-226</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-b158c4c583055c9fe49ac55aa07ad59458311430a624b575ca8b4aa3e317413b3</citedby><cites>FETCH-LOGICAL-c393t-b158c4c583055c9fe49ac55aa07ad59458311430a624b575ca8b4aa3e317413b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0739724005002171$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16303278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paczoska-Eliasiewicz, Helena Elzbieta</creatorcontrib><creatorcontrib>Proszkowiec-Weglarz, Monika</creatorcontrib><creatorcontrib>Proudman, John</creatorcontrib><creatorcontrib>Jacek, Tomasz</creatorcontrib><creatorcontrib>Mika, Maria</creatorcontrib><creatorcontrib>Sechman, Andrzej</creatorcontrib><creatorcontrib>Rzasa, Janusz</creatorcontrib><creatorcontrib>Gertler, Arieh</creatorcontrib><title>Exogenous leptin advances puberty in domestic hen</title><title>Domestic animal endocrinology</title><addtitle>Domest Anim Endocrinol</addtitle><description>The present study was undertaken to examine the effect of recombinant chicken leptin administered to fed ad libitum and feed-restricted immature chickens of a layer strain on ovarian development and the timing of sexual maturity. In the first experiment 11-week-old pullets (77 days of age) fed ad libitum were injected daily with leptin at four dose levels (4, 16, 64 and 256
μg/kg body weight) until sexual maturity (lay of the first egg). Leptin treatment at the highest dose significantly (
P
<
0.05) advanced the onset of puberty (day 116.3
±
1.0) in comparison to controls (day 121.3
±
1.2). The rises of luteinizing hormone, estradiol and progesterone in blood plasma were also advanced by leptin treatment. In the second experiment, both full-fed and feed-restricted pullets (79 days of age) were injected daily with leptin (256
μg/kg body weight). In birds fed ad libitum, exogenous leptin again significantly (
P
<
0.05) advanced first ovipostion (day 118.4
±
1.4 versus day 124.4
±
1.7), while abolishing the significant (
P
<
0.05) delay caused by feed restriction (day 131.5
±
1.6) and restoring the normal onset of sexual maturity (day 125.7
±
1.6). Analysis of the ovaries in 106-day-old pullets revealed that leptin injections advanced follicular development, particularly in birds fed ad libitum, and significantly (
P
<
0.01) reduced follicular apoptosis both in full-fed and feed-restricted birds. In conclusion, we have shown that in female chickens exogenous leptin advances the onset of puberty by attenuation of ovarian apoptosis and enhancement of folliculogenesis.</description><subject>ad libitum feeding</subject><subject>age at first egg</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Chicken</subject><subject>chickens</subject><subject>Chickens - physiology</subject><subject>dose response</subject><subject>estradiol</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Follicular development</subject><subject>Food Deprivation - physiology</subject><subject>hens</subject><subject>hormonal regulation</subject><subject>hormone secretion</subject><subject>In Situ Nick-End Labeling - veterinary</subject><subject>Leptin</subject><subject>Leptin - pharmacology</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Ovary</subject><subject>Ovary - drug effects</subject><subject>Ovary - physiology</subject><subject>progesterone</subject><subject>Progesterone - blood</subject><subject>Puberty</subject><subject>puberty onset</subject><subject>restricted feeding</subject><subject>Sexual Maturation - drug effects</subject><subject>Sexual Maturation - physiology</subject><subject>sexual maturity</subject><issn>0739-7240</issn><issn>1879-0054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhC0EoqXwCpATt5R1bMfOEVX8SZU4QM-W42yLqzYpdoro27NVKzhyGmv3G89qGLvhMObAy7vluOnWrg3YNuMCQNF0THLChtzoKqenPGVD0KLKdSFhwC5SWgKAJvc5G_BSgCi0GTL-8N0tsO22KVvhpg9t5pov13pM2WZbY-x3Gc0oDFMffPaB7SU7m7tVwqujjtjs8eF98pxPX59eJvfT3ItK9HnNlfHSKyNAKV_NUVbOK-UcaNeoStKCcynAlYWslVbemVo6J1BwLbmoxYjdHv7dxO5zS_F2HZLH1cq1SOfa0hhhqlITqA-gj11KEed2E8PaxZ3lYPdt2aX9bcvu29ovSMh5fYzY1mts_nzHegi4OQBz11m3iCHZ2VsBXADnILSpiLg_EEhVfAWMNnnK8diEiL6n4PDvGT-db4dl</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Paczoska-Eliasiewicz, Helena Elzbieta</creator><creator>Proszkowiec-Weglarz, Monika</creator><creator>Proudman, John</creator><creator>Jacek, Tomasz</creator><creator>Mika, Maria</creator><creator>Sechman, Andrzej</creator><creator>Rzasa, Janusz</creator><creator>Gertler, Arieh</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Exogenous leptin advances puberty in domestic hen</title><author>Paczoska-Eliasiewicz, Helena Elzbieta ; Proszkowiec-Weglarz, Monika ; Proudman, John ; Jacek, Tomasz ; Mika, Maria ; Sechman, Andrzej ; Rzasa, Janusz ; Gertler, Arieh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-b158c4c583055c9fe49ac55aa07ad59458311430a624b575ca8b4aa3e317413b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ad libitum feeding</topic><topic>age at first egg</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - physiology</topic><topic>Chicken</topic><topic>chickens</topic><topic>Chickens - physiology</topic><topic>dose response</topic><topic>estradiol</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Follicular development</topic><topic>Food Deprivation - physiology</topic><topic>hens</topic><topic>hormonal regulation</topic><topic>hormone secretion</topic><topic>In Situ Nick-End Labeling - veterinary</topic><topic>Leptin</topic><topic>Leptin - pharmacology</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Ovary</topic><topic>Ovary - drug effects</topic><topic>Ovary - physiology</topic><topic>progesterone</topic><topic>Progesterone - blood</topic><topic>Puberty</topic><topic>puberty onset</topic><topic>restricted feeding</topic><topic>Sexual Maturation - drug effects</topic><topic>Sexual Maturation - physiology</topic><topic>sexual maturity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paczoska-Eliasiewicz, Helena Elzbieta</creatorcontrib><creatorcontrib>Proszkowiec-Weglarz, Monika</creatorcontrib><creatorcontrib>Proudman, John</creatorcontrib><creatorcontrib>Jacek, Tomasz</creatorcontrib><creatorcontrib>Mika, Maria</creatorcontrib><creatorcontrib>Sechman, Andrzej</creatorcontrib><creatorcontrib>Rzasa, Janusz</creatorcontrib><creatorcontrib>Gertler, Arieh</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paczoska-Eliasiewicz, Helena Elzbieta</au><au>Proszkowiec-Weglarz, Monika</au><au>Proudman, John</au><au>Jacek, Tomasz</au><au>Mika, Maria</au><au>Sechman, Andrzej</au><au>Rzasa, Janusz</au><au>Gertler, Arieh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exogenous leptin advances puberty in domestic hen</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>31</volume><issue>3</issue><spage>211</spage><epage>226</epage><pages>211-226</pages><issn>0739-7240</issn><eissn>1879-0054</eissn><abstract>The present study was undertaken to examine the effect of recombinant chicken leptin administered to fed ad libitum and feed-restricted immature chickens of a layer strain on ovarian development and the timing of sexual maturity. In the first experiment 11-week-old pullets (77 days of age) fed ad libitum were injected daily with leptin at four dose levels (4, 16, 64 and 256
μg/kg body weight) until sexual maturity (lay of the first egg). Leptin treatment at the highest dose significantly (
P
<
0.05) advanced the onset of puberty (day 116.3
±
1.0) in comparison to controls (day 121.3
±
1.2). The rises of luteinizing hormone, estradiol and progesterone in blood plasma were also advanced by leptin treatment. In the second experiment, both full-fed and feed-restricted pullets (79 days of age) were injected daily with leptin (256
μg/kg body weight). In birds fed ad libitum, exogenous leptin again significantly (
P
<
0.05) advanced first ovipostion (day 118.4
±
1.4 versus day 124.4
±
1.7), while abolishing the significant (
P
<
0.05) delay caused by feed restriction (day 131.5
±
1.6) and restoring the normal onset of sexual maturity (day 125.7
±
1.6). Analysis of the ovaries in 106-day-old pullets revealed that leptin injections advanced follicular development, particularly in birds fed ad libitum, and significantly (
P
<
0.01) reduced follicular apoptosis both in full-fed and feed-restricted birds. In conclusion, we have shown that in female chickens exogenous leptin advances the onset of puberty by attenuation of ovarian apoptosis and enhancement of folliculogenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16303278</pmid><doi>10.1016/j.domaniend.2005.10.005</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0739-7240 |
| ispartof | Domestic animal endocrinology, 2006-10, Vol.31 (3), p.211-226 |
| issn | 0739-7240 1879-0054 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68838967 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ad libitum feeding age at first egg Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Body Weight - drug effects Body Weight - physiology Chicken chickens Chickens - physiology dose response estradiol Estradiol - blood Female Follicular development Food Deprivation - physiology hens hormonal regulation hormone secretion In Situ Nick-End Labeling - veterinary Leptin Leptin - pharmacology luteinizing hormone Luteinizing Hormone - blood Ovary Ovary - drug effects Ovary - physiology progesterone Progesterone - blood Puberty puberty onset restricted feeding Sexual Maturation - drug effects Sexual Maturation - physiology sexual maturity |
| title | Exogenous leptin advances puberty in domestic hen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T18%3A06%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exogenous%20leptin%20advances%20puberty%20in%20domestic%20hen&rft.jtitle=Domestic%20animal%20endocrinology&rft.au=Paczoska-Eliasiewicz,%20Helena%20Elzbieta&rft.date=2006-10-01&rft.volume=31&rft.issue=3&rft.spage=211&rft.epage=226&rft.pages=211-226&rft.issn=0739-7240&rft.eissn=1879-0054&rft_id=info:doi/10.1016/j.domaniend.2005.10.005&rft_dat=%3Cproquest_cross%3E68838967%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68838967&rft_id=info:pmid/16303278&rft_els_id=S0739724005002171&rfr_iscdi=true |