Transcriptomic changes in developing kidney exposed to chronic hypoxia
cDNA arrays compared gene expression in kidneys of neonatal mice subjected to 1, 2, and 4 weeks of chronic constant (CCH) or intermittent (CIH) hypoxia with normoxic littermates. Five to twenty percent of genes were regulated in each condition, with greater changes in CCH. Up-regulation of 42% of th...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2006-10, Vol.349 (1), p.329-338 |
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| creator | Iacobas, Dumitru A. Fan, Chenhao Iacobas, Sanda Spray, David C. Haddad, Gabriel G. |
| description | cDNA arrays compared gene expression in kidneys of neonatal mice subjected to 1, 2, and 4 weeks of chronic constant (CCH) or intermittent (CIH) hypoxia with normoxic littermates. Five to twenty percent of genes were regulated in each condition, with greater changes in CCH. Up-regulation of 42% of the solute carriers after 1 week of CCH suggests a strong activation of pH controlling pathways. Significant reduction in expression change of genes important in growth, development, and aging as a function of time indicates reduced maturation rate in CIH and CCH treatments. Regulated genes showed gender dependence in CCH, being higher in females than males at 1 week and higher in males than females thereafter. Transcriptional control was enhanced in CCH but not in CIH. Thus, CCH and CIH both alter gene expression and retard maturation with the more profound changes occurring in CCH than in CIH. |
| doi_str_mv | 10.1016/j.bbrc.2006.08.056 |
| format | Article |
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Five to twenty percent of genes were regulated in each condition, with greater changes in CCH. Up-regulation of 42% of the solute carriers after 1 week of CCH suggests a strong activation of pH controlling pathways. Significant reduction in expression change of genes important in growth, development, and aging as a function of time indicates reduced maturation rate in CIH and CCH treatments. Regulated genes showed gender dependence in CCH, being higher in females than males at 1 week and higher in males than females thereafter. Transcriptional control was enhanced in CCH but not in CIH. Thus, CCH and CIH both alter gene expression and retard maturation with the more profound changes occurring in CCH than in CIH.</description><subject>Aging</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Development</subject><subject>Female</subject><subject>Gender difference</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Growth factor</subject><subject>Heat shock protein</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypoxia</subject><subject>Kidney - embryology</subject><subject>Male</subject><subject>Maturation</subject><subject>Mice</subject><subject>Renal</subject><subject>Sex Factors</subject><subject>Solute carrier</subject><subject>Time Factors</subject><subject>Transcription, Genetic</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMoWh9_wIXMyt2MN5OZPMCNFKtCwY2Cu5DJ3GpqOxmTabH_3pQW3OnqLs53zoWPkEsKBQXKb-ZF0wRblAC8AFlAzQ_IiIKCvKRQHZIRpCQvFX07IacxzgEorbg6JieUK1aJqh6RyUswXbTB9YNfOpvZD9O9Y8xcl7W4xoXvXfeefbq2w02G372P2GaDT1zwXeI_Nr3_duacHM3MIuLF_p6R18n9y_gxnz4_PI3vprllsh7yGU1vWWW4sFbVsmGlgkYxptBYEFALoRohsQJo69IIwy1XnFMqSolYtYydkevdbh_81wrjoJcuWlwsTId-FTWXkglaw78gVUyKissEljvQBh9jwJnug1uasNEU9FaznuutZr3VrEHqpDmVrvbrq2aJ7W9l7zUBtzsAk4y1w6CjddhZbF1AO-jWu7_2fwCZeo2I</recordid><startdate>20061013</startdate><enddate>20061013</enddate><creator>Iacobas, Dumitru A.</creator><creator>Fan, Chenhao</creator><creator>Iacobas, Sanda</creator><creator>Spray, David C.</creator><creator>Haddad, Gabriel G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20061013</creationdate><title>Transcriptomic changes in developing kidney exposed to chronic hypoxia</title><author>Iacobas, Dumitru A. ; Fan, Chenhao ; Iacobas, Sanda ; Spray, David C. ; Haddad, Gabriel G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-f134734a67cc958b3290b9339eac0705779b78e400d52a7a6c696611728ee4d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Development</topic><topic>Female</topic><topic>Gender difference</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Growth factor</topic><topic>Heat shock protein</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypoxia</topic><topic>Kidney - embryology</topic><topic>Male</topic><topic>Maturation</topic><topic>Mice</topic><topic>Renal</topic><topic>Sex Factors</topic><topic>Solute carrier</topic><topic>Time Factors</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iacobas, Dumitru A.</creatorcontrib><creatorcontrib>Fan, Chenhao</creatorcontrib><creatorcontrib>Iacobas, Sanda</creatorcontrib><creatorcontrib>Spray, David C.</creatorcontrib><creatorcontrib>Haddad, Gabriel G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iacobas, Dumitru A.</au><au>Fan, Chenhao</au><au>Iacobas, Sanda</au><au>Spray, David C.</au><au>Haddad, Gabriel G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptomic changes in developing kidney exposed to chronic hypoxia</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-10-13</date><risdate>2006</risdate><volume>349</volume><issue>1</issue><spage>329</spage><epage>338</epage><pages>329-338</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>cDNA arrays compared gene expression in kidneys of neonatal mice subjected to 1, 2, and 4 weeks of chronic constant (CCH) or intermittent (CIH) hypoxia with normoxic littermates. Five to twenty percent of genes were regulated in each condition, with greater changes in CCH. Up-regulation of 42% of the solute carriers after 1 week of CCH suggests a strong activation of pH controlling pathways. Significant reduction in expression change of genes important in growth, development, and aging as a function of time indicates reduced maturation rate in CIH and CCH treatments. Regulated genes showed gender dependence in CCH, being higher in females than males at 1 week and higher in males than females thereafter. Transcriptional control was enhanced in CCH but not in CIH. Thus, CCH and CIH both alter gene expression and retard maturation with the more profound changes occurring in CCH than in CIH.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16934745</pmid><doi>10.1016/j.bbrc.2006.08.056</doi><tpages>10</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2006-10, Vol.349 (1), p.329-338 |
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| subjects | Aging Animals Apoptosis Development Female Gender difference Gene expression Gene Expression Regulation, Developmental Growth factor Heat shock protein Heat-Shock Proteins - metabolism Hydrogen-Ion Concentration Hypoxia Kidney - embryology Male Maturation Mice Renal Sex Factors Solute carrier Time Factors Transcription, Genetic |
| title | Transcriptomic changes in developing kidney exposed to chronic hypoxia |
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