Impaired β-Cell Function in Human Aging: Response to Nicotinic Acid-Induced Insulin Resistance

Context: Glucose tolerance declines with age and may involve impaired β-cell sensitivity to glucose and β-cell compensation for insulin resistance. Objective: We investigated β-cell sensitivity to glucose and β-cell compensation for nicotinic acid-induced insulin resistance in young (age 60 yr) peop...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2006-09, Vol.91 (9), p.3303-3309
Hauptverfasser:	Chang, Annette M., Smith, Marla J., Galecki, Andrzej T., Bloem, Cathie J., Halter, Jeffrey B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - physiology Biological and medical sciences Blood Glucose - metabolism Cholesterol - blood Cross-Over Studies Double-Blind Method Endocrinopathies Epinephrine - blood Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose - pharmacology Glucose Tolerance Test Humans Hypolipidemic Agents - pharmacology Insulin Resistance - physiology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Male Medical sciences Middle Aged Niacin - pharmacology Norepinephrine - blood Triglycerides - blood Vertebrates: endocrinology
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