Abnormal development of glomerular endothelial and mesangial cells in mice with targeted disruption of the lama3 gene

Mice with targeted disruption of the lama3 gene, which encodes the α3 chain of laminin-5 (α3β3γ2, 332), develop a blistering skin disease similar to junctional epidermolysis bullosa in humans. These animals also develop abnormalities in glomerulogenesis. In both wild-type and mutant animals (lama3−/...

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Veröffentlicht in:	Kidney international 2006-09, Vol.70 (6), p.1062-1071
Hauptverfasser:	Abrass, C.K., Berfield, A.K., Ryan, M.C., Carter, W.G., Hansen, K.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Animals, Newborn Basement Membrane - metabolism Basement Membrane - physiopathology Basement Membrane - ultrastructure Biological and medical sciences Blastocyst - cytology Capillaries - metabolism Capillaries - ultrastructure Cell Differentiation Cells, Cultured Collagen Type IV - metabolism Electroporation endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelial Cells - ultrastructure Female Gene Deletion Glomerular Mesangium - blood supply Glomerular Mesangium - ultrastructure glomerulogenesis Immunohistochemistry LAMA3 Laminin - genetics Laminin - metabolism Laminin - physiology Medical sciences Mesangial Cells - cytology Mesangial Cells - metabolism Mesangial Cells - ultrastructure Mice Mice, Knockout Microinjections Nephrology. Urinary tract diseases Pregnancy Rats Recombination, Genetic RNA, Messenger - metabolism Stem Cells - cytology
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