Effect of Artificial Tears on Visual Acuity
To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients. Nonrandomized prospective clinical trial. Prospective study in...
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| Veröffentlicht in: | American journal of ophthalmology 2005-11, Vol.140 (5), p.830-835 |
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| creator | Nilforoushan, Mohammad-Reza Latkany, Robert A. Speaker, Mark G. |
| description | To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients.
Nonrandomized prospective clinical trial.
Prospective study involving 20 patients (40 eyes) with SDE and 20 patients (40 eyes) with ADE, all 40 years and older, were recruited from a clinic setting over a 1-month period. Distance visual acuity was measured by the Early Treatment of Diabetic Retinopathy Study (ETDRS) vision chart and near visual acuity was measured by the Lighthouse Near Vision chart before and 30 seconds after instillation of one drop of CMC. Distance and near visual acuity was measured both with and without correction. The duration of action of CMC was measured at 1-minute intervals until the patient’s visual acuity returned to pretear level.
In both SDE and ADE groups, uncorrected and corrected near and distance vision showed a statistically significant improvement after the use of CMC (
P < .05). There was no statistically significant difference in improvement between the SDE and ADE groups in all categories (
P values > .05). The mean duration of improvement of vision was 2.93 minutes in the SDE group and 3.70 minutes in the ADE group (
P = .036).
CMC 0.5% provides a temporary yet significant improvement in the visual acuity of SDE and ADE patients. The effect of artificial tears on visual acuity may be of diagnostic value in detecting ocular surface abnormality in symptomatic and asymptomatic patients. |
| doi_str_mv | 10.1016/j.ajo.2005.05.001 |
| format | Article |
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Nonrandomized prospective clinical trial.
Prospective study involving 20 patients (40 eyes) with SDE and 20 patients (40 eyes) with ADE, all 40 years and older, were recruited from a clinic setting over a 1-month period. Distance visual acuity was measured by the Early Treatment of Diabetic Retinopathy Study (ETDRS) vision chart and near visual acuity was measured by the Lighthouse Near Vision chart before and 30 seconds after instillation of one drop of CMC. Distance and near visual acuity was measured both with and without correction. The duration of action of CMC was measured at 1-minute intervals until the patient’s visual acuity returned to pretear level.
In both SDE and ADE groups, uncorrected and corrected near and distance vision showed a statistically significant improvement after the use of CMC (
P < .05). There was no statistically significant difference in improvement between the SDE and ADE groups in all categories (
P values > .05). The mean duration of improvement of vision was 2.93 minutes in the SDE group and 3.70 minutes in the ADE group (
P = .036).
CMC 0.5% provides a temporary yet significant improvement in the visual acuity of SDE and ADE patients. The effect of artificial tears on visual acuity may be of diagnostic value in detecting ocular surface abnormality in symptomatic and asymptomatic patients.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2005.05.001</identifier><identifier>PMID: 16310460</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age ; Aged ; Biological and medical sciences ; Carboxymethylcellulose Sodium - administration & dosage ; Carboxymethylcellulose Sodium - pharmacology ; Dry Eye Syndromes - drug therapy ; Dry Eye Syndromes - physiopathology ; Eye care products ; Eye protection ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmic Solutions - administration & dosage ; Ophthalmic Solutions - pharmacology ; Ophthalmology ; Patients ; Preservatives, Pharmaceutical ; Prospective Studies ; Standardized tests ; Tears - chemistry ; Tears - metabolism ; Visual Acuity - drug effects ; Visual Acuity - physiology</subject><ispartof>American journal of ophthalmology, 2005-11, Vol.140 (5), p.830-835</ispartof><rights>2005 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-4706f90530a4667ad5f4f8d7d36c96c96f12488166b004ebb350f79d1a02dd323</citedby><cites>FETCH-LOGICAL-c475t-4706f90530a4667ad5f4f8d7d36c96c96f12488166b004ebb350f79d1a02dd323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939405005751$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17331323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16310460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nilforoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Latkany, Robert A.</creatorcontrib><creatorcontrib>Speaker, Mark G.</creatorcontrib><title>Effect of Artificial Tears on Visual Acuity</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients.
Nonrandomized prospective clinical trial.
Prospective study involving 20 patients (40 eyes) with SDE and 20 patients (40 eyes) with ADE, all 40 years and older, were recruited from a clinic setting over a 1-month period. Distance visual acuity was measured by the Early Treatment of Diabetic Retinopathy Study (ETDRS) vision chart and near visual acuity was measured by the Lighthouse Near Vision chart before and 30 seconds after instillation of one drop of CMC. Distance and near visual acuity was measured both with and without correction. The duration of action of CMC was measured at 1-minute intervals until the patient’s visual acuity returned to pretear level.
In both SDE and ADE groups, uncorrected and corrected near and distance vision showed a statistically significant improvement after the use of CMC (
P < .05). There was no statistically significant difference in improvement between the SDE and ADE groups in all categories (
P values > .05). The mean duration of improvement of vision was 2.93 minutes in the SDE group and 3.70 minutes in the ADE group (
P = .036).
CMC 0.5% provides a temporary yet significant improvement in the visual acuity of SDE and ADE patients. The effect of artificial tears on visual acuity may be of diagnostic value in detecting ocular surface abnormality in symptomatic and asymptomatic patients.</description><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carboxymethylcellulose Sodium - administration & dosage</subject><subject>Carboxymethylcellulose Sodium - pharmacology</subject><subject>Dry Eye Syndromes - drug therapy</subject><subject>Dry Eye Syndromes - physiopathology</subject><subject>Eye care products</subject><subject>Eye protection</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmic Solutions - pharmacology</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Preservatives, Pharmaceutical</subject><subject>Prospective Studies</subject><subject>Standardized tests</subject><subject>Tears - chemistry</subject><subject>Tears - metabolism</subject><subject>Visual Acuity - drug effects</subject><subject>Visual Acuity - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJSbZpfkAvwVDaS7E7Y8mSRU7LsvmAhV62vQqtPkDGayeSXci_r8wuBHoIvCAGHr3MPIR8QagQkP_sKt2NVQ3QVEsAP5AVtkKW2Eq8ICsAqEtJJbsin1Lq8sgFE5fkCjlFYBxW5MfWe2emYvTFOk7BBxN0X-ydjqkYh-JPSHOe12YO0-tn8tHrPrmb83tNft9v95vHcvfr4Wmz3pWGiWYqmQDuJTQUNONcaNt45lsrLOVGLvFYs7ZFzg8AzB0OtAEvpEUNtbW0ptfk-6n3OY4vs0uTOoZkXN_rwY1zUrxtKZUCM_j1P7Ab5zjk3RRyxiQI2kKm8ESZOKYUnVfPMRx1fFUIavGoOpU9qsWjWgJL8-25eT4cnX37cRaXgW9nQCejex_1YEJ64wSlmE_J3N2Jc1nY3-CiSia4wTgbYvau7BjeWeMf3oCL_A</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Nilforoushan, Mohammad-Reza</creator><creator>Latkany, Robert A.</creator><creator>Speaker, Mark G.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Effect of Artificial Tears on Visual Acuity</title><author>Nilforoushan, Mohammad-Reza ; Latkany, Robert A. ; Speaker, Mark G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-4706f90530a4667ad5f4f8d7d36c96c96f12488166b004ebb350f79d1a02dd323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carboxymethylcellulose Sodium - administration & dosage</topic><topic>Carboxymethylcellulose Sodium - pharmacology</topic><topic>Dry Eye Syndromes - drug therapy</topic><topic>Dry Eye Syndromes - physiopathology</topic><topic>Eye care products</topic><topic>Eye protection</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmic Solutions - administration & dosage</topic><topic>Ophthalmic Solutions - pharmacology</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Preservatives, Pharmaceutical</topic><topic>Prospective Studies</topic><topic>Standardized tests</topic><topic>Tears - chemistry</topic><topic>Tears - metabolism</topic><topic>Visual Acuity - drug effects</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nilforoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Latkany, Robert A.</creatorcontrib><creatorcontrib>Speaker, Mark G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nilforoushan, Mohammad-Reza</au><au>Latkany, Robert A.</au><au>Speaker, Mark G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Artificial Tears on Visual Acuity</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>140</volume><issue>5</issue><spage>830</spage><epage>835</epage><pages>830-835</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To study the effect of commonly used preservative free artificial tear, carboxymethylcellulose (CMC) 0.5% (Refresh Plus, Allergan, Irvine, California) on visual acuity in symptomatic dry eye (SDE) and asymptomatic dry eye (ADE) patients.
Nonrandomized prospective clinical trial.
Prospective study involving 20 patients (40 eyes) with SDE and 20 patients (40 eyes) with ADE, all 40 years and older, were recruited from a clinic setting over a 1-month period. Distance visual acuity was measured by the Early Treatment of Diabetic Retinopathy Study (ETDRS) vision chart and near visual acuity was measured by the Lighthouse Near Vision chart before and 30 seconds after instillation of one drop of CMC. Distance and near visual acuity was measured both with and without correction. The duration of action of CMC was measured at 1-minute intervals until the patient’s visual acuity returned to pretear level.
In both SDE and ADE groups, uncorrected and corrected near and distance vision showed a statistically significant improvement after the use of CMC (
P < .05). There was no statistically significant difference in improvement between the SDE and ADE groups in all categories (
P values > .05). The mean duration of improvement of vision was 2.93 minutes in the SDE group and 3.70 minutes in the ADE group (
P = .036).
CMC 0.5% provides a temporary yet significant improvement in the visual acuity of SDE and ADE patients. The effect of artificial tears on visual acuity may be of diagnostic value in detecting ocular surface abnormality in symptomatic and asymptomatic patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16310460</pmid><doi>10.1016/j.ajo.2005.05.001</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Aged Biological and medical sciences Carboxymethylcellulose Sodium - administration & dosage Carboxymethylcellulose Sodium - pharmacology Dry Eye Syndromes - drug therapy Dry Eye Syndromes - physiopathology Eye care products Eye protection Female Humans Male Medical sciences Middle Aged Miscellaneous Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - pharmacology Ophthalmology Patients Preservatives, Pharmaceutical Prospective Studies Standardized tests Tears - chemistry Tears - metabolism Visual Acuity - drug effects Visual Acuity - physiology |
| title | Effect of Artificial Tears on Visual Acuity |
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