Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus

Aims/hypothesis We investigated the effect of SB 203580, a pharmacological inhibitor of p38 mitogen-activated protein kinase (MAPK), on cardiac inflammation, cardiac fibrosis, and left ventricular function using an animal model of diabetic cardiomyopathy. Materials and methods Diabetes mellitus was...

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Veröffentlicht in:	Diabetologia 2006-10, Vol.49 (10), p.2507-2513
Hauptverfasser:	Westermann, D, Rutschow, S, Van Linthout, S, Linderer, A, Bücker-Gärtner, C, Sobirey, M, Riad, A, Pauschinger, M, Schultheiss, H.-P, Tschöpe, C
Format:	Artikel
Sprache:	eng
Schlagworte:	animal disease models Animals Biological and medical sciences Body Weight Cardiac inflammation Cardiology Cardiology. Vascular system Cardiomyopathy Cardiovascular disease Cytokines Cytokines - metabolism Diabetes diabetes mellitus Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control Diabetic cardiomyopathy diastolic blood pressure drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies enzyme inhibition enzyme inhibitors Enzyme Inhibitors - therapeutic use Etiopathogenesis. Screening. Investigations. Target tissue resistance fibrosis Heart Heart - anatomy & histology Heart - physiopathology Heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement hemodynamics Imidazoles - therapeutic use Inflammation Inflammation - physiopathology interleukin-1 interleukin-6 Investigations Kinases Laboratory animals lymphotoxin Male Medical sciences Mice Mice, Inbred C57BL mitogen-activated protein kinase Myocarditis. Cardiomyopathies Organ Size Oxidative stress p38 MAPK p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pressure-volume loops protein phosphorylation Proteins Pyridines - therapeutic use Systole - physiology systolic blood pressure tumor necrosis factor-alpha Type 1 diabetes mellitus Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control Ventricular Function, Left
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