Proximal effects in the modulation of nitric oxide synthase reactivity: a QM-MM study

Nitric oxide synthases (NOS) are heme proteins that have a cysteine residue as axial ligand, which generates nitric oxide (NO). The proximal environment, specifically H-bonding between tryptophan (Trp) 178 and thiolate, has been proposed to play a fundamental role in the modulation of NOS activity....

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Veröffentlicht in:	Journal of biological inorganic chemistry 2005-10, Vol.10 (6), p.595-604
Hauptverfasser:	Fernández, M Laura, Martí, Marcelo A, Crespo, Alejandro, Estrin, Darío A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Computational Biology Heme - chemistry Hemeproteins - chemistry Hemeproteins - genetics Humans Hydrogen Bonding Iron - chemistry Models, Molecular Nitric Oxide Synthase Type III - chemistry Nitric Oxide Synthase Type III - genetics Tryptophan - chemistry Tryptophan - genetics
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