Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination

The design of particulate vaccine delivery systems, particularly for mucosal surfaces, has been a focus of interest in recent years. In this context, we have previously described the development and the characterization of a new nanosized delivery system, consisting of a model antigen adsorbed to ch...

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Veröffentlicht in:	Journal of controlled release 2006-09, Vol.114 (3), p.348-358
Hauptverfasser:	Borges, Olga, Cordeiro-da-Silva, Anabela, Romeijn, Stefan G., Amidi, Maryam, de Sousa, Adriano, Borchard, Gerrit, Junginger, Hans E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - administration & dosage Animals Biological and medical sciences Cell Survival - drug effects Chitosan Chitosan - administration & dosage Coated nanoparticles Cytotoxicity Drug Delivery Systems Female General pharmacology Glucuronic Acid - administration & dosage Hexuronic Acids - administration & dosage Hydrogen-Ion Concentration Male Medical sciences Mice Mice, Inbred BALB C Nanostructures Ovalbumin - administration & dosage Ovalbumin - chemistry Ovalbumin - immunology Peyer's patches Peyer's Patches - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar Sodium alginate Solubility Spleen - cytology Spleen - drug effects Vaccination
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