Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin
Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking o...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-10, Vol.194 (7), p.1003-1007 |
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| creator | Hirsh, Mark I. Cohen, Victoria |
| description | Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax |
| doi_str_mv | 10.1086/507311 |
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This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/507311</identifier><identifier>PMID: 16960789</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Anthrax ; Antigens, Bacterial - pharmacology ; Antimalarials - pharmacology ; Bacteria ; Bacterial Toxins - pharmacology ; Biological and medical sciences ; Chloroquine - pharmacology ; Cytokines ; Dendritic cells ; Down-Regulation ; Epithelial cells ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Humans ; Infectious diseases ; Interleukin-10 - metabolism ; Lymphocyte Activation - drug effects ; Lymphocytes ; Macrophages ; Medical sciences ; Microbiology ; Percentages ; Phosphorylation ; T lymphocytes ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Toxins ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>The Journal of infectious diseases, 2006-10, Vol.194 (7), p.1003-1007</ispartof><rights>Copyright 2006 Infectious Diseases Society of America</rights><rights>2006 by the Infectious Diseases Society of America 2006</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-f781e82f3212f330139a1e3c6f1a09b6d6648a5f14dc4f15f47e2e5f727fd3f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30052709$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30052709$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18139623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16960789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirsh, Mark I.</creatorcontrib><creatorcontrib>Cohen, Victoria</creatorcontrib><title>Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax</description><subject>Adult</subject><subject>Anthrax</subject><subject>Antigens, Bacterial - pharmacology</subject><subject>Antimalarials - pharmacology</subject><subject>Bacteria</subject><subject>Bacterial Toxins - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chloroquine - pharmacology</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Down-Regulation</subject><subject>Epithelial cells</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interleukin-10 - metabolism</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Percentages</subject><subject>Phosphorylation</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Toxins</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EuP0zAQB3ALgdiywDcAmQPcAn7Fj-OqAnal8JAIaMXFcp2xmiWNg52g9tuTKtX2hLh4DvPTjOeP0HNK3lKi5buSKE7pA7SiJVeFlJQ_RCtCGCuoNuYCPcn5jhAiuFSP0QWVRhKlzQp9Wm-7mOLvqe0Bf03wB_ox4xpXh92wjf4wAv42DUOCnNvY45u-mTw0eHPAV_24TW6PKxi3rsN13Lf9U_QouC7Ds1O9RN8_vK_X10X15ePN-qoqvGBiLILSFDQLnNH54YRy4yhwLwN1xGxkI6XQrgxUNF4EWgahgEEZFFOh4cHwS_RmmTscvw55tLs2e-g610OcspVa8_l28V9IjTBMKnmGPsWcEwQ7pHbn0sFSYo8J2yXhGb48TZw2O2jO7BTpDF6fgMvedSG53rf57PR8rWR8dq8WF6fh38teLOYujzHdK05IyRQ57iqWfptH2N_3XfplpeKqtNe3P-2Piny-LWtma_4Xk-qkUA</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Hirsh, Mark I.</creator><creator>Cohen, Victoria</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin</title><author>Hirsh, Mark I. ; Cohen, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-f781e82f3212f330139a1e3c6f1a09b6d6648a5f14dc4f15f47e2e5f727fd3f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Anthrax</topic><topic>Antigens, Bacterial - pharmacology</topic><topic>Antimalarials - pharmacology</topic><topic>Bacteria</topic><topic>Bacterial Toxins - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chloroquine - pharmacology</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Down-Regulation</topic><topic>Epithelial cells</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interleukin-10 - metabolism</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Percentages</topic><topic>Phosphorylation</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Toxins</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirsh, Mark I.</creatorcontrib><creatorcontrib>Cohen, Victoria</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirsh, Mark I.</au><au>Cohen, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>194</volume><issue>7</issue><spage>1003</spage><epage>1007</epage><pages>1003-1007</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Lysosomal processing of lethal toxin (LTX) is a key event in the pathogenesis of anthrax. This study investigated the ability of chloroquine (CQ) to interfere with this processing and thereby to reduce suppression of T lymphocytes. T lymphocytes isolated from blood were activated, by cross-linking of CD3, in both the absence and presence of LTX and CQ and then were assayed by flow cytometry and immunoblotting. LTX was found to disrupt intracellular signaling, and it down-regulated T lymphocyte function. CQ significantly reduced the harmful effects of LTX and protected the activation and cytokine production of T lymphocytes. This effect may indicate a promising strategy in the treatment of anthrax</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16960789</pmid><doi>10.1086/507311</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Anthrax Antigens, Bacterial - pharmacology Antimalarials - pharmacology Bacteria Bacterial Toxins - pharmacology Biological and medical sciences Chloroquine - pharmacology Cytokines Dendritic cells Down-Regulation Epithelial cells Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Infectious diseases Interleukin-10 - metabolism Lymphocyte Activation - drug effects Lymphocytes Macrophages Medical sciences Microbiology Percentages Phosphorylation T lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Toxins Tumor Necrosis Factor-alpha - metabolism |
| title | Chloroquine Prevents T Lymphocyte Suppression Induced by Anthrax Lethal Toxin |
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