Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia

Mutations of the FLT3, c-KIT, c-FMS, KRAS, NRAS, BRAF and CEBPA genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal-transduction pathway are frequent in acute myeloid leukemia (AML). We examined 140 patients with therapy-related myelodysplasia or AML (t-MDS/t-AML) for point mutations of thes...

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Veröffentlicht in:	Leukemia 2005-12, Vol.19 (12), p.2232-2240
Hauptverfasser:	CHRISTIANSEN, D. H, ANDERSEN, M. K, DESTA, F, PEDERSEN-BJERGAARD, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Adolescent Adult Aged Alkylating agents Alkylation AML1 protein Biological and medical sciences c-Kit protein CCAAT-Enhancer-Binding Protein-alpha - genetics Chemotherapy Child Cooperation Cytogenetics DNA Mutational Analysis Female fms-Like Tyrosine Kinase 3 Genes Hematologic and hematopoietic diseases Humans Karyotypes Kinases Leukemia Leukemia, Myeloid - etiology Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukemogenesis Male Medical prognosis Medical sciences Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Neoplasms, Second Primary - genetics Point Mutation Protein-tyrosine kinase receptors Proto-Oncogene Proteins B-raf - genetics Radiation therapy ras Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, Macrophage Colony-Stimulating Factor - genetics Receptors Signal Transduction Transcription factors Tyrosine
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