Within-host evolution of CD8+-TL epitopes encoded by overlapping and non-overlapping reading frames of simian immunodeficiency virus

In order to understand the impact of overlapping reading frames on natural selection by host CD8+ T lymphocytes (CD8+-TL), we analyzed the pattern of nucleotide substitution in simian immunodeficiency virus (SIV) genomes sampled from populations at time of death in 35 rhesus monkeys. Both the mean n...

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Veröffentlicht in:	Bioinformatics 2005-11, Vol.21 (Suppl_3), p.iii39-iii44
Hauptverfasser:	Hughes, Austin L., Piontkivska, Helen, Krebs, Kendall C., O'Connor, David H., Watkins, David I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - physiology Epitope Mapping - methods Epitopes, T-Lymphocyte - genetics Evolution, Molecular Macaca mulatta Open Reading Frames - genetics Selection, Genetic Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics
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