A subtype of multiple sclerosis defined by an activated immune defense program

Given the heterogeneous nature of multiple sclerosis (MS), we applied DNA microarray technology to determine whether variability is reflected in peripheral blood (PB) cells. In this study, we studied whole-blood gene expression profiles of 29 patients with relapsing-remitting MS (RRMS) and 25 age- a...

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Veröffentlicht in:	Genes and immunity 2006-09, Vol.7 (6), p.522-531
Hauptverfasser:	van Baarsen, L G M, van der Pouw Kraan, T C T M, Kragt, J J, Baggen, J M C, Rustenburg, F, Hooper, T, Meilof, J F, Fero, M J, Dijkstra, C D, Polman, C H, Verweij, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Case-Control Studies Causes of Cluster Analysis DNA microarrays Gene Expression Gene Expression Regulation Genetic aspects Genetic Heterogeneity Genomics Human Genetics Humans Immune response Immune system Immunoglobulins Immunology Interferon Interferon Type I - immunology Interferon Type I - metabolism Magnetic resonance imaging Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - genetics Multiple Sclerosis, Relapsing-Remitting - immunology Oligonucleotide Array Sequence Analysis original-article Peripheral blood Physiological aspects Poxviridae Infections - genetics Signal Transduction Transcription Up-Regulation Viruses
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