DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma
Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of...
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| Veröffentlicht in: | Haematologica (Roma) 2006-09, Vol.91 (9), p.1252-1256 |
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| creator | Voso, MT Gumiero, D D'Alo', F Guidi, F Mansueto, G Di Febo, AL Massini, G Martini, M Larocca, LM Hohaus, S Leone, G |
| description | Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p |
| format | Article |
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We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p</description><identifier>ISSN: 0390-6078</identifier><identifier>EISSN: 1592-8721</identifier><identifier>PMID: 16956827</identifier><language>eng</language><publisher>Pavia: Haematologica</publisher><subject>Adult ; Aged ; Apoptosis Regulatory Proteins - analysis ; Apoptosis Regulatory Proteins - genetics ; Biological and medical sciences ; Biomarkers, Tumor ; Bone Marrow - enzymology ; Calcium-Calmodulin-Dependent Protein Kinases - analysis ; Calcium-Calmodulin-Dependent Protein Kinases - genetics ; Death-Associated Protein Kinases ; DNA Methylation ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Follicular - diagnosis ; Lymphoma, Follicular - enzymology ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Treatment Outcome</subject><ispartof>Haematologica (Roma), 2006-09, Vol.91 (9), p.1252-1256</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18107734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16956827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voso, MT</creatorcontrib><creatorcontrib>Gumiero, D</creatorcontrib><creatorcontrib>D'Alo', F</creatorcontrib><creatorcontrib>Guidi, F</creatorcontrib><creatorcontrib>Mansueto, G</creatorcontrib><creatorcontrib>Di Febo, AL</creatorcontrib><creatorcontrib>Massini, G</creatorcontrib><creatorcontrib>Martini, M</creatorcontrib><creatorcontrib>Larocca, LM</creatorcontrib><creatorcontrib>Hohaus, S</creatorcontrib><creatorcontrib>Leone, G</creatorcontrib><title>DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma</title><title>Haematologica (Roma)</title><addtitle>Haematologica</addtitle><description>Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p</description><subject>Adult</subject><subject>Aged</subject><subject>Apoptosis Regulatory Proteins - analysis</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Bone Marrow - enzymology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - analysis</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - genetics</subject><subject>Death-Associated Protein Kinases</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Follicular - diagnosis</subject><subject>Lymphoma, Follicular - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Treatment Outcome</subject><issn>0390-6078</issn><issn>1592-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgiruu_gXJRW-FNGmS5risn7CgoJ5Dmk5tNG1q01L67y24sqc5zMM7vHOC1ilXNMklTU_RmjBFEkFkvkIXMX4RQolS8hytUqG4yKlco7e77Wvy7VoTAddzB30DQz17M7jQYtfioQZchBZwY_o-TDhUuFuW0A4RT26ocRW8d3b0psd-bro6NOYSnVXGR7g6zA36eLh_3z0l-5fH5912n9RUkiFhwEyRK2kzw1lpTclKxbPSgOAKyiqrKpZKywsqaCaA0wIK4ExkJSmotblkG3T7l9v14WeEOOjGRQvemxbCGLXIl4qMkgVeH-BYNFDqrndLnVn_v2EBNwdgojW-6k1rXTy6PCVSsux4sXaf9eR60LEx3i-xVE_TpFKtdEo5Zb83qXXP</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Voso, MT</creator><creator>Gumiero, D</creator><creator>D'Alo', F</creator><creator>Guidi, F</creator><creator>Mansueto, G</creator><creator>Di Febo, AL</creator><creator>Massini, G</creator><creator>Martini, M</creator><creator>Larocca, LM</creator><creator>Hohaus, S</creator><creator>Leone, G</creator><general>Haematologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma</title><author>Voso, MT ; Gumiero, D ; D'Alo', F ; Guidi, F ; Mansueto, G ; Di Febo, AL ; Massini, G ; Martini, M ; Larocca, LM ; Hohaus, S ; Leone, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-3e3ab897c4a53dcad3d954dae659edf4ff317c5b26246e52bebe5364d0b2cc873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apoptosis Regulatory Proteins - analysis</topic><topic>Apoptosis Regulatory Proteins - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Bone Marrow - enzymology</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - analysis</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases - genetics</topic><topic>Death-Associated Protein Kinases</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Follicular - diagnosis</topic><topic>Lymphoma, Follicular - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voso, MT</creatorcontrib><creatorcontrib>Gumiero, D</creatorcontrib><creatorcontrib>D'Alo', F</creatorcontrib><creatorcontrib>Guidi, F</creatorcontrib><creatorcontrib>Mansueto, G</creatorcontrib><creatorcontrib>Di Febo, AL</creatorcontrib><creatorcontrib>Massini, G</creatorcontrib><creatorcontrib>Martini, M</creatorcontrib><creatorcontrib>Larocca, LM</creatorcontrib><creatorcontrib>Hohaus, S</creatorcontrib><creatorcontrib>Leone, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Haematologica (Roma)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voso, MT</au><au>Gumiero, D</au><au>D'Alo', F</au><au>Guidi, F</au><au>Mansueto, G</au><au>Di Febo, AL</au><au>Massini, G</au><au>Martini, M</au><au>Larocca, LM</au><au>Hohaus, S</au><au>Leone, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma</atitle><jtitle>Haematologica (Roma)</jtitle><addtitle>Haematologica</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>91</volume><issue>9</issue><spage>1252</spage><epage>1256</epage><pages>1252-1256</pages><issn>0390-6078</issn><eissn>1592-8721</eissn><abstract>Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p</abstract><cop>Pavia</cop><pub>Haematologica</pub><pmid>16956827</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Apoptosis Regulatory Proteins - analysis Apoptosis Regulatory Proteins - genetics Biological and medical sciences Biomarkers, Tumor Bone Marrow - enzymology Calcium-Calmodulin-Dependent Protein Kinases - analysis Calcium-Calmodulin-Dependent Protein Kinases - genetics Death-Associated Protein Kinases DNA Methylation Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Follicular - diagnosis Lymphoma, Follicular - enzymology Male Medical sciences Middle Aged Prognosis Treatment Outcome |
| title | DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma |
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