Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats
Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral a...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2006, Vol.68(8), pp.803-807 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Noto, T.(Astellas Pharmaceutical Inc., Osaka (Japan). Medicinal Biology Research Lab.) Furuichi, Y Ishiye, M Matsuoka, N Aramori, I Mutoh, S Yanagihara T Manabe, N |
| description | Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral artery (MCA) for 60 min in rats with immunohistochemical staining for hypoxia (2-nitroimidazole hypoxia marker: hypoxyprobe-1 adducts). Our results showed that tissue hypoxia expressed as positive staining for hypoxyprobe-1 adducts preceded neuronal degeneration. Platelets and granulocytes were detected close to the hypoxyprobe-1 adducts positive area. These results suggested that the hypoxic environment could persist even after reperfusion of MCA, because of vascular obstruction with accumulation of platelets and granulocytes. |
| doi_str_mv | 10.1292/jvms.68.803 |
| format | Article |
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Medicinal Biology Research Lab.) ; Furuichi, Y ; Ishiye, M ; Matsuoka, N ; Aramori, I ; Mutoh, S ; Yanagihara T ; Manabe, N</creator><creatorcontrib>Noto, T.(Astellas Pharmaceutical Inc., Osaka (Japan). Medicinal Biology Research Lab.) ; Furuichi, Y ; Ishiye, M ; Matsuoka, N ; Aramori, I ; Mutoh, S ; Yanagihara T ; Manabe, N</creatorcontrib><description>Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral artery (MCA) for 60 min in rats with immunohistochemical staining for hypoxia (2-nitroimidazole hypoxia marker: hypoxyprobe-1 adducts). Our results showed that tissue hypoxia expressed as positive staining for hypoxyprobe-1 adducts preceded neuronal degeneration. Platelets and granulocytes were detected close to the hypoxyprobe-1 adducts positive area. These results suggested that the hypoxic environment could persist even after reperfusion of MCA, because of vascular obstruction with accumulation of platelets and granulocytes.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.68.803</identifier><identifier>PMID: 16953079</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ANIMAL TISSUES ; Animals ; ANOXIA ; ANOXIE ; Brain - blood supply ; Brain - metabolism ; Brain - pathology ; Brain Ischemia - physiopathology ; Gene Expression Regulation, Enzymologic ; GRANULOCITOS ; GRANULOCYTE ; GRANULOCYTES ; hypoxia ; immunohistochemistry ; IMMUNOLOGICAL TECHNIQUES ; Integrin beta3 - metabolism ; Male ; Peroxidase - metabolism ; platelet ; PLATELETS ; RAT ; RATA ; RATS ; Rats, Wistar ; Reperfusion Injury - pathology ; TECHNIQUE IMMUNOLOGIQUE ; TECNICAS INMUNOLOGICAS ; TEJIDOS ANIMALES ; THROMBOCYTE ; Time Factors ; TISSU ANIMAL ; TROMBOCITOS</subject><ispartof>Journal of Veterinary Medical Science, 2006, Vol.68(8), pp.803-807</ispartof><rights>2006 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-5ad15bd9d95bf5e0745130831cb8ee7e9aac47d0c0ee3df37ecc35b8006c0bdd3</citedby><cites>FETCH-LOGICAL-c643t-5ad15bd9d95bf5e0745130831cb8ee7e9aac47d0c0ee3df37ecc35b8006c0bdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16953079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noto, T.(Astellas Pharmaceutical Inc., Osaka (Japan). Medicinal Biology Research Lab.)</creatorcontrib><creatorcontrib>Furuichi, Y</creatorcontrib><creatorcontrib>Ishiye, M</creatorcontrib><creatorcontrib>Matsuoka, N</creatorcontrib><creatorcontrib>Aramori, I</creatorcontrib><creatorcontrib>Mutoh, S</creatorcontrib><creatorcontrib>Yanagihara T</creatorcontrib><creatorcontrib>Manabe, N</creatorcontrib><title>Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Intravascular accumulation of blood cells after brain ischemia-reperfusion can cause obstruction of cerebral blood flow and tissue hypoxia/ischemia as a consequence. In the present study, we examined temporal and topographic changes of tissue hypoxia/ischemia after occlusion of the middle cerebral artery (MCA) for 60 min in rats with immunohistochemical staining for hypoxia (2-nitroimidazole hypoxia marker: hypoxyprobe-1 adducts). Our results showed that tissue hypoxia expressed as positive staining for hypoxyprobe-1 adducts preceded neuronal degeneration. Platelets and granulocytes were detected close to the hypoxyprobe-1 adducts positive area. These results suggested that the hypoxic environment could persist even after reperfusion of MCA, because of vascular obstruction with accumulation of platelets and granulocytes.</description><subject>ANIMAL TISSUES</subject><subject>Animals</subject><subject>ANOXIA</subject><subject>ANOXIE</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>GRANULOCITOS</subject><subject>GRANULOCYTE</subject><subject>GRANULOCYTES</subject><subject>hypoxia</subject><subject>immunohistochemistry</subject><subject>IMMUNOLOGICAL TECHNIQUES</subject><subject>Integrin beta3 - metabolism</subject><subject>Male</subject><subject>Peroxidase - metabolism</subject><subject>platelet</subject><subject>PLATELETS</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - pathology</subject><subject>TECHNIQUE IMMUNOLOGIQUE</subject><subject>TECNICAS INMUNOLOGICAS</subject><subject>TEJIDOS ANIMALES</subject><subject>THROMBOCYTE</subject><subject>Time Factors</subject><subject>TISSU ANIMAL</subject><subject>TROMBOCITOS</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2L1TAUhoMoznV05VopCG7kXk-aNB-7kWH8YkAX4zqk6WlvLm1Tk1Zn_r259DIDbnSTAzkPD2_yEvKSwo6Wunx_-DWknVA7BewR2VDG5VZyph-TDWgqtrKs4Iw8S-kAUFIu9FNyRoWuGEi9Id0NDlOIti_s2BRzmEIX7bT3rphiaH2PqQhtMfuUFiz2d1O49bZoQ9-H337sijnaMXkc53znssRhxPpo88ntccisH4to5_ScPGltn_DFaZ6THx-vbi4_b6-_ffpy-eF66wRn87ayDa3qRje6qtsKQfKKMlCMulohStTWOi4bcIDImpZJdI5VtQIQDuqmYefk7erN8X8umGYz5CjY93bEsCQjlCplqdQ_wRKEqDiT_wFyDZzxDL75CzyEJY75tSZ_u5IUJBOZerdSLoaUIrZmin6w8c5QMMc-zbHPnNPkPjP9-uRc6gGbB_ZUYAYuVuCQZtvhPWDj7F2PD7L1yM77ldvbaHDMilerorXB2C76ZL5-LwEkAJdCsj_EBb3G</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Noto, T.(Astellas Pharmaceutical Inc., Osaka (Japan). 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| subjects | ANIMAL TISSUES Animals ANOXIA ANOXIE Brain - blood supply Brain - metabolism Brain - pathology Brain Ischemia - physiopathology Gene Expression Regulation, Enzymologic GRANULOCITOS GRANULOCYTE GRANULOCYTES hypoxia immunohistochemistry IMMUNOLOGICAL TECHNIQUES Integrin beta3 - metabolism Male Peroxidase - metabolism platelet PLATELETS RAT RATA RATS Rats, Wistar Reperfusion Injury - pathology TECHNIQUE IMMUNOLOGIQUE TECNICAS INMUNOLOGICAS TEJIDOS ANIMALES THROMBOCYTE Time Factors TISSU ANIMAL TROMBOCITOS |
| title | Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats |
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