Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction
To characterize the peri-infarction zone using T2-weighted (T2w) magnetic resonance imaging (MRI) and infarct size on delayed enhancement (DE) MRI in patients with acute myocardial infarction (AMI). In 65 patients, short-axis T2w and DE MRI images were acquired 5 +/- 3 d after AMI. The MRI was analy...
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| Veröffentlicht in: | European radiology 2006-10, Vol.16 (10), p.2350-2357 |
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| creator | Stork, Alexander Lund, Gunnar K Muellerleile, Kai Bansmann, Paul M Nolte-Ernsting, Claus Kemper, Joern Begemann, Philipp G C Adam, Gerhard |
| description | To characterize the peri-infarction zone using T2-weighted (T2w) magnetic resonance imaging (MRI) and infarct size on delayed enhancement (DE) MRI in patients with acute myocardial infarction (AMI). In 65 patients, short-axis T2w and DE MRI images were acquired 5 +/- 3 d after AMI. The MRI was analyzed using a threshold method defining infarct size on DE MRI and edema on T2w MRI as areas with signal intensity larger than +2 SD above remote normal myocardium. The peri-infarction zone was calculated as the difference between the size of edema and the infarct size. The size of edema on T2w MRI (31.3 +/- 13.4% of LV area) was larger than the infarct size on DE MRI (20.3 +/- 10.4% of LV area, p< 0.0001). The size of the peri-infarction zone was 11.0 +/- 10.0% of the LV area. Good correlation was found between infarct size on DE MRI and peak creatine kinase (CK) isoenzyme MB (r = 0.65, p< 0.0001), but there was no correlation between the size of the peri-infarction zone and CK MB (r = 0.05, p = 0.67). The peri-infarction zone was larger in patients with an infarct size or =28% of the LV area (6.7 +/- 9.0% of the LV area, p< 0.05). The peri-infarction zone does not correlate with enzymatic parameters of infarct size and is substantially larger in small infarcts, indicating viable myocardium. |
| doi_str_mv | 10.1007/s00330-006-0232-3 |
| format | Article |
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In 65 patients, short-axis T2w and DE MRI images were acquired 5 +/- 3 d after AMI. The MRI was analyzed using a threshold method defining infarct size on DE MRI and edema on T2w MRI as areas with signal intensity larger than +2 SD above remote normal myocardium. The peri-infarction zone was calculated as the difference between the size of edema and the infarct size. The size of edema on T2w MRI (31.3 +/- 13.4% of LV area) was larger than the infarct size on DE MRI (20.3 +/- 10.4% of LV area, p< 0.0001). The size of the peri-infarction zone was 11.0 +/- 10.0% of the LV area. Good correlation was found between infarct size on DE MRI and peak creatine kinase (CK) isoenzyme MB (r = 0.65, p< 0.0001), but there was no correlation between the size of the peri-infarction zone and CK MB (r = 0.05, p = 0.67). The peri-infarction zone was larger in patients with an infarct size <28% of the LV area (12.6 +/- 10.0% LV area) compared with patients with an infarct size > or =28% of the LV area (6.7 +/- 9.0% of the LV area, p< 0.05). The peri-infarction zone does not correlate with enzymatic parameters of infarct size and is substantially larger in small infarcts, indicating viable myocardium.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-006-0232-3</identifier><identifier>PMID: 16625349</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Contrast Media ; Correlation ; Creatine ; Creatine kinase ; Edema ; Edema - diagnosis ; Female ; Gadolinium DTPA ; Heart attacks ; Humans ; Image acquisition ; Image enhancement ; Image Processing, Computer-Assisted ; Kinases ; Linear Models ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - pathology ; Myocardium</subject><ispartof>European radiology, 2006-10, Vol.16 (10), p.2350-2357</ispartof><rights>Springer-Verlag 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-1bbf5cf549da61fc734b0a69c492fe99ffec0116541e41c5fba6190327b831923</citedby><cites>FETCH-LOGICAL-c327t-1bbf5cf549da61fc734b0a69c492fe99ffec0116541e41c5fba6190327b831923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16625349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stork, Alexander</creatorcontrib><creatorcontrib>Lund, Gunnar K</creatorcontrib><creatorcontrib>Muellerleile, Kai</creatorcontrib><creatorcontrib>Bansmann, Paul M</creatorcontrib><creatorcontrib>Nolte-Ernsting, Claus</creatorcontrib><creatorcontrib>Kemper, Joern</creatorcontrib><creatorcontrib>Begemann, Philipp G C</creatorcontrib><creatorcontrib>Adam, Gerhard</creatorcontrib><title>Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>To characterize the peri-infarction zone using T2-weighted (T2w) magnetic resonance imaging (MRI) and infarct size on delayed enhancement (DE) MRI in patients with acute myocardial infarction (AMI). In 65 patients, short-axis T2w and DE MRI images were acquired 5 +/- 3 d after AMI. The MRI was analyzed using a threshold method defining infarct size on DE MRI and edema on T2w MRI as areas with signal intensity larger than +2 SD above remote normal myocardium. The peri-infarction zone was calculated as the difference between the size of edema and the infarct size. The size of edema on T2w MRI (31.3 +/- 13.4% of LV area) was larger than the infarct size on DE MRI (20.3 +/- 10.4% of LV area, p< 0.0001). The size of the peri-infarction zone was 11.0 +/- 10.0% of the LV area. Good correlation was found between infarct size on DE MRI and peak creatine kinase (CK) isoenzyme MB (r = 0.65, p< 0.0001), but there was no correlation between the size of the peri-infarction zone and CK MB (r = 0.05, p = 0.67). The peri-infarction zone was larger in patients with an infarct size <28% of the LV area (12.6 +/- 10.0% LV area) compared with patients with an infarct size > or =28% of the LV area (6.7 +/- 9.0% of the LV area, p< 0.05). The peri-infarction zone does not correlate with enzymatic parameters of infarct size and is substantially larger in small infarcts, indicating viable myocardium.</description><subject>Adult</subject><subject>Aged</subject><subject>Contrast Media</subject><subject>Correlation</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Edema</subject><subject>Edema - diagnosis</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Image enhancement</subject><subject>Image Processing, Computer-Assisted</subject><subject>Kinases</subject><subject>Linear Models</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardium</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkV9rFDEUxYModq1-AF8kIPQtmjvJ_MmjLFoLFaG0zyGTuemkzGTWJEPZfgW_tNnuQsGnJCfnnHvhR8hH4F-A8_Zr4lwIzjhvGK9ExcQrsgFZLsA7-ZpsuBIda5WSZ-RdSg-ccwWyfUvOoGmqWki1IX-3o4nGZoz-yWS_BLo4mkeku6IwH5yJ9ll-WgLSNflwT28r9oj-fsw40F83V9SEgQ44mT0ODMNogsUZQ37-84HuSm95Jvro80iNXTPSeb9YEwdvJvoy4z1548yU8MPpPCd3P77fbn-y69-XV9tv18yKqs0M-t7V1tVSDaYBZ1she24aZaWqHCrlHFoO0NQSUIKtXV9sipds3wlQlTgnF8feXVz-rJiynn2yOE0m4LIm3XRd1YLsivHzf8aHZY2h7KYFVK0EIbpDHRxdNi4pRXR6F_1s4l4D1wdO-shJF076wEmLkvl0al77GYeXxAmM-AcjfI8d</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Stork, Alexander</creator><creator>Lund, Gunnar K</creator><creator>Muellerleile, Kai</creator><creator>Bansmann, Paul M</creator><creator>Nolte-Ernsting, Claus</creator><creator>Kemper, Joern</creator><creator>Begemann, Philipp G C</creator><creator>Adam, Gerhard</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200610</creationdate><title>Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction</title><author>Stork, Alexander ; Lund, Gunnar K ; Muellerleile, Kai ; Bansmann, Paul M ; Nolte-Ernsting, Claus ; Kemper, Joern ; Begemann, Philipp G C ; Adam, Gerhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-1bbf5cf549da61fc734b0a69c492fe99ffec0116541e41c5fba6190327b831923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Contrast Media</topic><topic>Correlation</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Edema</topic><topic>Edema - 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Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stork, Alexander</au><au>Lund, Gunnar K</au><au>Muellerleile, Kai</au><au>Bansmann, Paul M</au><au>Nolte-Ernsting, Claus</au><au>Kemper, Joern</au><au>Begemann, Philipp G C</au><au>Adam, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2006-10</date><risdate>2006</risdate><volume>16</volume><issue>10</issue><spage>2350</spage><epage>2357</epage><pages>2350-2357</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>To characterize the peri-infarction zone using T2-weighted (T2w) magnetic resonance imaging (MRI) and infarct size on delayed enhancement (DE) MRI in patients with acute myocardial infarction (AMI). In 65 patients, short-axis T2w and DE MRI images were acquired 5 +/- 3 d after AMI. The MRI was analyzed using a threshold method defining infarct size on DE MRI and edema on T2w MRI as areas with signal intensity larger than +2 SD above remote normal myocardium. The peri-infarction zone was calculated as the difference between the size of edema and the infarct size. The size of edema on T2w MRI (31.3 +/- 13.4% of LV area) was larger than the infarct size on DE MRI (20.3 +/- 10.4% of LV area, p< 0.0001). The size of the peri-infarction zone was 11.0 +/- 10.0% of the LV area. Good correlation was found between infarct size on DE MRI and peak creatine kinase (CK) isoenzyme MB (r = 0.65, p< 0.0001), but there was no correlation between the size of the peri-infarction zone and CK MB (r = 0.05, p = 0.67). The peri-infarction zone was larger in patients with an infarct size <28% of the LV area (12.6 +/- 10.0% LV area) compared with patients with an infarct size > or =28% of the LV area (6.7 +/- 9.0% of the LV area, p< 0.05). The peri-infarction zone does not correlate with enzymatic parameters of infarct size and is substantially larger in small infarcts, indicating viable myocardium.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16625349</pmid><doi>10.1007/s00330-006-0232-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Contrast Media Correlation Creatine Creatine kinase Edema Edema - diagnosis Female Gadolinium DTPA Heart attacks Humans Image acquisition Image enhancement Image Processing, Computer-Assisted Kinases Linear Models Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Myocardial infarction Myocardial Infarction - pathology Myocardium |
| title | Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction |
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