Osteoblast lineage properties in giant cell tumors of bone

Giant cell tumors of bone (GCTs), among the most common primary bone tumors, are characterized by the formation of abundant osteoclast-like multinucleated giant cells (MNCs). It is not yet clear about the origin of GCTs and which cells in the lesion are the true neoplastic component. Several recent...

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Veröffentlicht in:	Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2005-11, Vol.10 (6), p.581-588
Hauptverfasser:	Murata, Atsushi, Fujita, Takuya, Kawahara, Norio, Tsuchiya, Hiroyuki, Tomita, Katsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Biomarkers - metabolism Bone Neoplasms - metabolism Bone Neoplasms - pathology Cattle Cell Differentiation - physiology Cell Lineage Cells, Cultured Female Giant Cell Tumor of Bone - metabolism Giant Cell Tumor of Bone - pathology Humans Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Middle Aged Osteoblasts - cytology Osteoblasts - physiology Osteocalcin - metabolism
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