A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction

Overactivity of the dopaminergic system in the brain is considered to be a contributing factor to the development and symptomatology of schizophrenia. Therefore, the GABAergic control of dopamine functions was assessed by disrupting the gene encoding the alpha3 subunit of the GABA(A) receptor. alpha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (47), p.17154-17159
Hauptverfasser:	Yee, B K, Keist, R, von Boehmer, L, Studer, R, Benke, D, Hagenbuch, N, Dong, Y, Malenka, R C, Fritschy, J-M, Bluethmann, H, Feldon, J, Möhler, H, Rudolph, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Animals Anti-Anxiety Agents - pharmacology Diazepam - pharmacology Disease Models, Animal Dopamine - physiology Electrophysiology GABA Modulators - pharmacology Gene Targeting Haloperidol - pharmacology Immunohistochemistry Ion Channel Gating - genetics Ion Channel Gating - physiology Mice Mice, Knockout Motor Activity - drug effects Motor Activity - genetics Motor Activity - physiology Protein Subunits - deficiency Protein Subunits - genetics Protein Subunits - physiology Receptors, GABA-A - deficiency Receptors, GABA-A - genetics Receptors, GABA-A - physiology Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - physiopathology
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