Potential scope of action of tissue kallikreins in CNS immune-mediated disease
The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells...
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| Veröffentlicht in: | Journal of neuroimmunology 2006-09, Vol.178 (1), p.167-176 |
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| container_title | Journal of neuroimmunology |
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| creator | Scarisbrick, I.A. Blaber, S.I. Tingling, J.T. Rodriguez, M. Blaber, M. Christophi, G.P. |
| description | The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis. |
| doi_str_mv | 10.1016/j.jneuroim.2006.05.022 |
| format | Article |
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We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. 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We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis.</description><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - metabolism</subject><subject>Brain - immunology</subject><subject>Brain - metabolism</subject><subject>Demyelinating Autoimmune Diseases, CNS - immunology</subject><subject>Demyelinating Autoimmune Diseases, CNS - metabolism</subject><subject>Enzyme</subject><subject>Hormones - pharmacology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Jurkat cell</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>Multiple sclerosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>Serine protease</subject><subject>Spinal Cord - immunology</subject><subject>Spinal Cord - metabolism</subject><subject>Spleen - immunology</subject><subject>Spleen - metabolism</subject><subject>Steroid hormone</subject><subject>Steroids - pharmacology</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - metabolism</subject><subject>Tissue Kallikreins - biosynthesis</subject><subject>Tissue Kallikreins - drug effects</subject><subject>Tissue Kallikreins - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotlb_QpmVuxnzmGQyO6X4glIFdR3SzB1IOzOpSUbw35vSiktX9y6-cw58CM0JLggm4mZTbAYYvbN9QTEWBeYFpvQETYmsaC5LSk7RNIE85xWVE3QRwgZjwllZn6MJEZKWgtIpWr26CEO0usuCcTvIXJtpE60b9l-0IYyQbXXX2a0HO4TMDtli9ZbZvh8HyHtorI7QZI0NoANcorNWdwGujneGPh7u3xdP-fLl8Xlxt8wNq6uYg2TEtG3FOa4xq5qaMq6NrEpcQkOJMLU2DRUMs5ZoKRIArFzrijDK5drUbIauD7077z5HCFH1NhjoOj2AG4MSUlLBU_4_kNSsTK0sgeIAGu9C8NCqnbe99t-KYLVXrjbqV7naK1eYq6Q8BefHhXGddPzFjo4TcHsAIAn5suBVMBYGk9R5MFE1zv638QMtypVL</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Scarisbrick, I.A.</creator><creator>Blaber, S.I.</creator><creator>Tingling, J.T.</creator><creator>Rodriguez, M.</creator><creator>Blaber, M.</creator><creator>Christophi, G.P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Potential scope of action of tissue kallikreins in CNS immune-mediated disease</title><author>Scarisbrick, I.A. ; Blaber, S.I. ; Tingling, J.T. ; Rodriguez, M. ; Blaber, M. ; Christophi, G.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-e831cff75509037d9235ac87404ed216c9acd26303f1a867d9e34ba713258bc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Bone Marrow - immunology</topic><topic>Bone Marrow - metabolism</topic><topic>Brain - immunology</topic><topic>Brain - metabolism</topic><topic>Demyelinating Autoimmune Diseases, CNS - immunology</topic><topic>Demyelinating Autoimmune Diseases, CNS - metabolism</topic><topic>Enzyme</topic><topic>Hormones - pharmacology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Jurkat cell</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Multiple sclerosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>Serine protease</topic><topic>Spinal Cord - immunology</topic><topic>Spinal Cord - metabolism</topic><topic>Spleen - immunology</topic><topic>Spleen - metabolism</topic><topic>Steroid hormone</topic><topic>Steroids - pharmacology</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - metabolism</topic><topic>Tissue Kallikreins - biosynthesis</topic><topic>Tissue Kallikreins - drug effects</topic><topic>Tissue Kallikreins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scarisbrick, I.A.</creatorcontrib><creatorcontrib>Blaber, S.I.</creatorcontrib><creatorcontrib>Tingling, J.T.</creatorcontrib><creatorcontrib>Rodriguez, M.</creatorcontrib><creatorcontrib>Blaber, M.</creatorcontrib><creatorcontrib>Christophi, G.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scarisbrick, I.A.</au><au>Blaber, S.I.</au><au>Tingling, J.T.</au><au>Rodriguez, M.</au><au>Blaber, M.</au><au>Christophi, G.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential scope of action of tissue kallikreins in CNS immune-mediated disease</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>178</volume><issue>1</issue><spage>167</spage><epage>176</epage><pages>167-176</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>The objective of this study was to define the potential scope of action of tissue kallikreins in T cell-mediated disease of the CNS. We demonstrate quantitatively the differential expression of all 15 human tissue kallikreins within brain, spinal cord and immune compartments. In human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol. The patterns of co-expression and co-regulation described point to novel effector roles for select tissue kallikreins in neurological disorders involving T cells, such as multiple sclerosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16824622</pmid><doi>10.1016/j.jneuroim.2006.05.022</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bone Marrow - immunology Bone Marrow - metabolism Brain - immunology Brain - metabolism Demyelinating Autoimmune Diseases, CNS - immunology Demyelinating Autoimmune Diseases, CNS - metabolism Enzyme Hormones - pharmacology Humans Inflammation Jurkat cell Lymphocyte Activation - immunology Lymphocytes - immunology Lymphocytes - metabolism Multiple sclerosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Serine protease Spinal Cord - immunology Spinal Cord - metabolism Spleen - immunology Spleen - metabolism Steroid hormone Steroids - pharmacology Thymus Gland - immunology Thymus Gland - metabolism Tissue Kallikreins - biosynthesis Tissue Kallikreins - drug effects Tissue Kallikreins - immunology |
| title | Potential scope of action of tissue kallikreins in CNS immune-mediated disease |
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