Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics

The efficacy of tramadol (T) in children is not clearly understood because it is still unknown the ability of that population to form the active metabolite O-demethyltramadol (M1) and, whether or not the parent compound has a contribution to the efficacy. The aim was to develop a population pharmaco...

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Veröffentlicht in:	Pharmaceutical research 2006-09, Vol.23 (9), p.2014-2023
Hauptverfasser:	GARRIDO, Maria J, HABRE, Walid, ROMBOUT, Ferdinand, TROCONIZ, Inaki F
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analgesics Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Biological and medical sciences Body Weight - physiology Child Child, Preschool Crying Data Interpretation, Statistical Double-Blind Method Female General pharmacology Humans Male Medical sciences Models, Statistical Movement - drug effects Pain management Pain, Postoperative - drug therapy Pain, Postoperative - metabolism Pain, Postoperative - psychology Pediatrics Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Population Predictive Value of Tests Signal transduction Surgery Tramadol - pharmacokinetics Tramadol - therapeutic use
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