Circadian Fluctuations of Macular Edema in Patients with Morning Vision Blurring: Correlation with Arterial Pressure and Effect of Light Deprivation
This study explored the causes of vision fluctuations in patients with chronic macular edema. Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after aw...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2005-12, Vol.46 (12), p.4707-4711 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Paques, Michel Massin, Pascale Sahel, Jose A Gaudric, Alain Bergmann, Jean-Francois Azancot, Suzanne Levy, Bernard I Vicaut, Eric |
| description | This study explored the causes of vision fluctuations in patients with chronic macular edema.
Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after awakening at 7 AM, and at 7 PM), which comprised assessment of Early Treatment Diabetic Retinopathy Study score and measurement of macular thickness (MT) by optical coherence tomography. Ocular perfusion pressure was calculated from ambulatory arterial pressure measurement. In addition, after the 7 AM measurements, the patients were randomly selected for monocular light deprivation during the day to evaluate the role of retinal illumination in these fluctuations.
Circadian fluctuation of MT was documented in all patients. At 7 AM, mean visual acuity (VA) was worse (mean +/- SD of the difference: 6.5 +/- 7.2 points; P < 0.002) and mean MT was higher (57.4 +/- 34 microm; P < 0.001) than at 7 PM. Fluctuations of MT were correlated to fluctuation of arterial pressure (P = 0.05), but were not influenced by monocular light deprivation.
In most patients complaining of visual fluctuations due to macular edema secondary to CRVO, MT and VA were found to undergo a circadian cycle. These short-term anatomic and functional variations were associated with arterial pressure variations (that is, macular thickening was inversely correlated to the arterial pressure drop during the night), but were not due to light deprivation. |
| doi_str_mv | 10.1167/iovs.05-0638 |
| format | Article |
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Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after awakening at 7 AM, and at 7 PM), which comprised assessment of Early Treatment Diabetic Retinopathy Study score and measurement of macular thickness (MT) by optical coherence tomography. Ocular perfusion pressure was calculated from ambulatory arterial pressure measurement. In addition, after the 7 AM measurements, the patients were randomly selected for monocular light deprivation during the day to evaluate the role of retinal illumination in these fluctuations.
Circadian fluctuation of MT was documented in all patients. At 7 AM, mean visual acuity (VA) was worse (mean +/- SD of the difference: 6.5 +/- 7.2 points; P < 0.002) and mean MT was higher (57.4 +/- 34 microm; P < 0.001) than at 7 PM. Fluctuations of MT were correlated to fluctuation of arterial pressure (P = 0.05), but were not influenced by monocular light deprivation.
In most patients complaining of visual fluctuations due to macular edema secondary to CRVO, MT and VA were found to undergo a circadian cycle. These short-term anatomic and functional variations were associated with arterial pressure variations (that is, macular thickening was inversely correlated to the arterial pressure drop during the night), but were not due to light deprivation.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.05-0638</identifier><identifier>PMID: 16303968</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Pressure - physiology ; Circadian Rhythm - physiology ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Intraocular Pressure - physiology ; Light ; Macular Edema - etiology ; Macular Edema - physiopathology ; Male ; Middle Aged ; Retina - physiopathology ; Retina - radiation effects ; Retinal Vein Occlusion - complications ; Retinal Vein Occlusion - physiopathology ; Sensory Deprivation ; Vertebrates: nervous system and sense organs ; Vision Disorders - physiopathology ; Visual Acuity - physiology</subject><ispartof>Investigative ophthalmology & visual science, 2005-12, Vol.46 (12), p.4707-4711</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-fc4ff5b0238ccb53329d92ac9f64d245e00b55fb51e8cce8cb72dee8d1ab80a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17310502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16303968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paques, Michel</creatorcontrib><creatorcontrib>Massin, Pascale</creatorcontrib><creatorcontrib>Sahel, Jose A</creatorcontrib><creatorcontrib>Gaudric, Alain</creatorcontrib><creatorcontrib>Bergmann, Jean-Francois</creatorcontrib><creatorcontrib>Azancot, Suzanne</creatorcontrib><creatorcontrib>Levy, Bernard I</creatorcontrib><creatorcontrib>Vicaut, Eric</creatorcontrib><title>Circadian Fluctuations of Macular Edema in Patients with Morning Vision Blurring: Correlation with Arterial Pressure and Effect of Light Deprivation</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>This study explored the causes of vision fluctuations in patients with chronic macular edema.
Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after awakening at 7 AM, and at 7 PM), which comprised assessment of Early Treatment Diabetic Retinopathy Study score and measurement of macular thickness (MT) by optical coherence tomography. Ocular perfusion pressure was calculated from ambulatory arterial pressure measurement. In addition, after the 7 AM measurements, the patients were randomly selected for monocular light deprivation during the day to evaluate the role of retinal illumination in these fluctuations.
Circadian fluctuation of MT was documented in all patients. At 7 AM, mean visual acuity (VA) was worse (mean +/- SD of the difference: 6.5 +/- 7.2 points; P < 0.002) and mean MT was higher (57.4 +/- 34 microm; P < 0.001) than at 7 PM. Fluctuations of MT were correlated to fluctuation of arterial pressure (P = 0.05), but were not influenced by monocular light deprivation.
In most patients complaining of visual fluctuations due to macular edema secondary to CRVO, MT and VA were found to undergo a circadian cycle. These short-term anatomic and functional variations were associated with arterial pressure variations (that is, macular thickening was inversely correlated to the arterial pressure drop during the night), but were not due to light deprivation.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>Circadian Rhythm - physiology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Light</subject><subject>Macular Edema - etiology</subject><subject>Macular Edema - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retina - physiopathology</subject><subject>Retina - radiation effects</subject><subject>Retinal Vein Occlusion - complications</subject><subject>Retinal Vein Occlusion - physiopathology</subject><subject>Sensory Deprivation</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vision Disorders - physiopathology</subject><subject>Visual Acuity - physiology</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9v1DAQxS1ERZeFG2fkC3AhxX_ixMutLNuCtFV7KFwtxxl3jRyntZ1GfA8-MN7uSj1YI8u_eeN5D6F3lJxR2rRf3PiYzoioSMPlC7SgQrBKtJK_RAtC66YiNalP0euU_hDCKGXkFTqlDSd81cgF-rd20eje6YAv_GTypLMbQ8KjxVfaTF5HvOlh0NgFfFPeIOSEZ5d3-GqMwYU7_Nul0oG_-SnGcv-K12OM4J90DuR5zBCd9vgmQkpTBKxDjzfWgsn7QVt3t8v4O9xH9_jU9gadWO0TvD3WJfp1sbld_6i215c_1-fbynBBc2VNba3oCOPSmE5wzlb9immzsk3ds1oAIZ0QthMUClBO17IeQPZUd5Jozpfo40H3Po4PE6SsBpcMeK8DjFNSjZRMtFQW8PMBNHFMKYJV5a-Djn8VJWqfgtqnoIhQ-xQK_v6oO3UD9M_w0fYCfDgCOhntbdTBuPTMtZwSUfZaok8Hblcsml0ElQbtfZGlap7nulGUqbolLf8PwBGhFQ</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Paques, Michel</creator><creator>Massin, Pascale</creator><creator>Sahel, Jose A</creator><creator>Gaudric, Alain</creator><creator>Bergmann, Jean-Francois</creator><creator>Azancot, Suzanne</creator><creator>Levy, Bernard I</creator><creator>Vicaut, Eric</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Circadian Fluctuations of Macular Edema in Patients with Morning Vision Blurring: Correlation with Arterial Pressure and Effect of Light Deprivation</title><author>Paques, Michel ; Massin, Pascale ; Sahel, Jose A ; Gaudric, Alain ; Bergmann, Jean-Francois ; Azancot, Suzanne ; Levy, Bernard I ; Vicaut, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-fc4ff5b0238ccb53329d92ac9f64d245e00b55fb51e8cce8cb72dee8d1ab80a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - physiology</topic><topic>Circadian Rhythm - physiology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Light</topic><topic>Macular Edema - etiology</topic><topic>Macular Edema - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retina - physiopathology</topic><topic>Retina - radiation effects</topic><topic>Retinal Vein Occlusion - complications</topic><topic>Retinal Vein Occlusion - physiopathology</topic><topic>Sensory Deprivation</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vision Disorders - physiopathology</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paques, Michel</creatorcontrib><creatorcontrib>Massin, Pascale</creatorcontrib><creatorcontrib>Sahel, Jose A</creatorcontrib><creatorcontrib>Gaudric, Alain</creatorcontrib><creatorcontrib>Bergmann, Jean-Francois</creatorcontrib><creatorcontrib>Azancot, Suzanne</creatorcontrib><creatorcontrib>Levy, Bernard I</creatorcontrib><creatorcontrib>Vicaut, Eric</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paques, Michel</au><au>Massin, Pascale</au><au>Sahel, Jose A</au><au>Gaudric, Alain</au><au>Bergmann, Jean-Francois</au><au>Azancot, Suzanne</au><au>Levy, Bernard I</au><au>Vicaut, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian Fluctuations of Macular Edema in Patients with Morning Vision Blurring: Correlation with Arterial Pressure and Effect of Light Deprivation</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>46</volume><issue>12</issue><spage>4707</spage><epage>4711</epage><pages>4707-4711</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>This study explored the causes of vision fluctuations in patients with chronic macular edema.
Fifteen patients (16 eyes) with vision blurring at awakening due to post-central retinal vein occlusion (CRVO) macular edema underwent three examination sessions over 24 hours (at 7 PM, immediately after awakening at 7 AM, and at 7 PM), which comprised assessment of Early Treatment Diabetic Retinopathy Study score and measurement of macular thickness (MT) by optical coherence tomography. Ocular perfusion pressure was calculated from ambulatory arterial pressure measurement. In addition, after the 7 AM measurements, the patients were randomly selected for monocular light deprivation during the day to evaluate the role of retinal illumination in these fluctuations.
Circadian fluctuation of MT was documented in all patients. At 7 AM, mean visual acuity (VA) was worse (mean +/- SD of the difference: 6.5 +/- 7.2 points; P < 0.002) and mean MT was higher (57.4 +/- 34 microm; P < 0.001) than at 7 PM. Fluctuations of MT were correlated to fluctuation of arterial pressure (P = 0.05), but were not influenced by monocular light deprivation.
In most patients complaining of visual fluctuations due to macular edema secondary to CRVO, MT and VA were found to undergo a circadian cycle. These short-term anatomic and functional variations were associated with arterial pressure variations (that is, macular thickening was inversely correlated to the arterial pressure drop during the night), but were not due to light deprivation.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>16303968</pmid><doi>10.1167/iovs.05-0638</doi><tpages>5</tpages></addata></record> |
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| issn | 0146-0404 1552-5783 1552-5783 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Biological and medical sciences Blood Pressure - physiology Circadian Rhythm - physiology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Humans Intraocular Pressure - physiology Light Macular Edema - etiology Macular Edema - physiopathology Male Middle Aged Retina - physiopathology Retina - radiation effects Retinal Vein Occlusion - complications Retinal Vein Occlusion - physiopathology Sensory Deprivation Vertebrates: nervous system and sense organs Vision Disorders - physiopathology Visual Acuity - physiology |
| title | Circadian Fluctuations of Macular Edema in Patients with Morning Vision Blurring: Correlation with Arterial Pressure and Effect of Light Deprivation |
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