A novel approach and protocol for discovering extremely low-abundance proteins in serum

The proteomic analysis of serum (plasma) has been a major approach to determining biomarkers essential for early disease diagnoses and drug discoveries. The determination of these biomarkers, however, is analytically challenging since the dynamic concentration range of serum proteins/peptides is ext...

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Veröffentlicht in:	Proteomics (Weinheim) 2006-09, Vol.6 (17), p.4845-4855
Hauptverfasser:	Tanaka, Yoshinori, Akiyama, Hideo, Kuroda, Toshihiko, Jung, Giman, Tanahashi, Kazuhiro, Sugaya, Hiroyuki, Utsumi, Jun, Kawasaki, Hiroshi, Hirano, Hisashi
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D-LC Analytical, structural and metabolic biochemistry Biological and medical sciences Blood Proteins - analysis Blood Proteins - chemistry Blood Proteins - isolation & purification Blood Proteins - metabolism Chromatography, Liquid Fundamental and applied biological sciences. Psychology Hollow-fiber membrane Humans Mass Spectrometry Miscellaneous Molecular Weight Plasma Proteins Sensitivity and Specificity Serum
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