Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus

The crystal structure of GST Nu2‐2 (HpolGSTN2‐2) from the model hookworm nematode Heligmosomoides polygyrus has been solved by the molecular replacement method and refined to a resolution of 1.71 Å, providing the first structural data from a class of nematode‐specific GSTs. By structural alignment w...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2005-12, Vol.61 (4), p.1024-1031
Hauptverfasser:	Schuller, David J., Liu, Qun, Kriksunov, Irina A., Campbell, Alison M., Barrett, John, Brophy, Peter M., Hao, Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites crystal structure Crystallography, X-Ray Enzyme Inhibitors - pharmacology Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - chemistry Glutathione Transferase - metabolism glutathione transferase Nu2-2 Heligmosomatoidea - enzymology Humans ligand binding Ligands Models, Molecular molecular replacement method Protein Structure, Secondary Strongylida Infections
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