Synthesis of Nitrogen- and Oxygen-Containing Macrocycles-Derivatives of Lithocholic Acid

Palladium‐catalyzed amination of 3,24‐bis(3‐bromophenoxy)cholane (4) with various polyamines and polyoxadiamines 5 taken in 1:1 ratio was used for the synthesis of the macrocycles 6, which contain steroidal and polyamine moieties and were obtained in 38–65 % yields. The same reaction with excess pol...

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Veröffentlicht in:	Chemistry : a European journal 2005-11, Vol.11 (23), p.7030-7039
Hauptverfasser:	Averin, Alexei D., Ranyuk, Elena R., Lukashev, Nikolai V., Beletskaya, Irina P.
Format:	Artikel
Sprache:	eng
Schlagworte:	amination catalysis Lithocholic Acid - chemical synthesis macrocycles Magnetic Resonance Spectroscopy Nitrogen - chemistry Oxygen - chemistry polyamines Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization steroids
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